| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4269301 | B | Uncompetitive inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.078 uM assessed as Vmax for substrate using IMP as fixed substrate at 500 uM and NAD as second substrate with varying concentrations of 31.25 to 1300 uM (Rvb = 1.5 microM/min) | Cryptococcus neoformans | 1 | ALA4265991 | assay format | Scientific Literature | |
| 2. | ALA4269302 | B | Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NAD | Cryptococcus neoformans | 16 | ALA4265991 | assay format | Scientific Literature | |
| 3. | ALA4269311 | B | Uncompetitive inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.039 uM assessed as Vmax for substrate using IMP as fixed substrate at 500 uM and NAD as second substrate with varying concentrations of 31.25 to 1300 uM (Rvb = 1.5 microM/min) | Cryptococcus neoformans | 1 | ALA4265991 | assay format | Scientific Literature | |
| 4. | ALA4269312 | B | Uncompetitive inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.039 uM assessed as Km for substrate using IMP as fixed substrate at 500 uM and NAD as second substrate with varying concentrations of 31.25 to 1300 uM (Rvb = 257.5 +/- 23 microM) | Cryptococcus neoformans | 1 | ALA4265991 | assay format | Scientific Literature | |
| 5. | ALA4269313 | B | Uncompetitive inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.039 uM assessed as Kcat for substrate using IMP as fixed substrate at 500 uM and NAD as second substrate with varying concentrations of 31.25 to 1300 uM (Rvb = 21.5 /s) | Cryptococcus neoformans | 1 | ALA4265991 | assay format | Scientific Literature | |
| 6. | ALA4269314 | B | Uncompetitive inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.039 uM assessed as Vmax for substrate using NAD as fixed substrate at 700 uM and IMP as second substrate with varying concentrations of 25 to 800 uM (Rvb = 1.5 microM/min) | Cryptococcus neoformans | 1 | ALA4265991 | assay format | Scientific Literature | |
| 7. | ALA4269315 | B | Uncompetitive inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.039 uM assessed as Km for substrate using NAD as fixed substrate at 700 uM and IMP as second substrate with varying concentrations of 25 to 800 uM (Rvb = 257.5 +/- 23 microM) | Cryptococcus neoformans | 1 | ALA4265991 | assay format | Scientific Literature | |
| 8. | ALA4269316 | B | Uncompetitive inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.039 uM assessed as Kcat for substrate using NAD as fixed substrate at 700 uM and IMP as second substrate with varying concentrations of 25 to 800 uM (Rvb = 21.5 /s) | Cryptococcus neoformans | 1 | ALA4265991 | assay format | Scientific Literature | |
| 9. | ALA4269317 | B | Uncompetitive inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.078 uM assessed as Km for substrate using IMP as fixed substrate at 500 uM and NAD as second substrate with varying concentrations of 31.25 to 1300 uM (Rvb = 257.5 +/- 23 microM) | Cryptococcus neoformans | 1 | ALA4265991 | assay format | Scientific Literature | |
| 10. | ALA4269318 | B | Uncompetitive inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.078 uM assessed as Kcat for substrate using IMP as fixed substrate at 500 uM and NAD as second substrate with varying concentrations of 31.25 to 1300 uM (Rvb = 21.5 /s) | Cryptococcus neoformans | 1 | ALA4265991 | assay format | Scientific Literature | |
| 11. | ALA4269319 | B | Uncompetitive inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.078 uM assessed as Vmax for substrate using NAD as fixed substrate at 700 uM and IMP as second substrate with varying concentrations of 25 to 800 uM (Rvb = 1.5 microM/min) | Cryptococcus neoformans | 1 | ALA4265991 | assay format | Scientific Literature | |
| 12. | ALA4269320 | B | Uncompetitive inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.078 uM assessed as Km for substrate using NAD as fixed substrate at 700 uM and IMP as second substrate with varying concentrations of 25 to 800 uM (Rvb = 257.5 +/- 23 microM) | Cryptococcus neoformans | 1 | ALA4265991 | assay format | Scientific Literature | |
| 13. | ALA4269321 | B | Uncompetitive inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.078 uM assessed as Kcat for substrate using NAD as fixed substrate at 700 uM and IMP as second substrate with varying concentrations of 25 to 800 uM (Rvb = 21.5 /s) | Cryptococcus neoformans | 1 | ALA4265991 | assay format | Scientific Literature | |
| 14. | ALA4269322 | B | Uncompetitive inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.156 uM assessed as Vmax for substrate using IMP as fixed substrate at 500 uM and NAD as second substrate with varying concentrations of 31.25 to 1300 uM (Rvb = 1.5 microM/min) | Cryptococcus neoformans | 1 | ALA4265991 | assay format | Scientific Literature | |
| 15. | ALA4269323 | B | Uncompetitive inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.156 uM assessed as Km for substrate using IMP as fixed substrate at 500 uM and NAD as second substrate with varying concentrations of 31.25 to 1300 uM (Rvb = 257.5 +/- 23 microM) | Cryptococcus neoformans | 1 | ALA4265991 | assay format | Scientific Literature | |
| 16. | ALA4269324 | B | Uncompetitive inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.156 uM assessed as Kcat for substrate using IMP as fixed substrate at 500 uM and NAD as second substrate with varying concentrations of 31.25 to 1300 uM (Rvb = 21.5 /s) | Cryptococcus neoformans | 1 | ALA4265991 | assay format | Scientific Literature | |
| 17. | ALA4269325 | B | Uncompetitive inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.156 uM assessed as Vmax for substrate using NAD as fixed substrate at 700 uM and IMP as second substrate with varying concentrations of 25 to 800 uM (Rvb = 1.5 microM/min) | Cryptococcus neoformans | 1 | ALA4265991 | assay format | Scientific Literature | |
| 18. | ALA4269326 | B | Uncompetitive inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.156 uM assessed as Km for substrate using NAD as fixed substrate at 700 uM and IMP as second substrate with varying concentrations of 25 to 800 uM (Rvb = 257.5 +/- 23 microM) | Cryptococcus neoformans | 1 | ALA4265991 | assay format | Scientific Literature | |
| 19. | ALA4269327 | B | Uncompetitive inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.156 uM assessed as Kcat for substrate using NAD as fixed substrate at 700 uM and IMP as second substrate with varying concentrations of 25 to 800 uM (Rvb = 21.5 /s) | Cryptococcus neoformans | 1 | ALA4265991 | assay format | Scientific Literature | |
| 20. | ALA4269328 | B | Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.3 uM assessed as Vmax for substrate using IMP as fixed substrate at 500 uM and NAD as second substrate with varying concentrations of 31.25 to 1300 uM (Rvb = 1.5 microM/min) | Cryptococcus neoformans | 2 | ALA4265991 | assay format | Scientific Literature |
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