# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4136611 | Binding | Inhibition of cystathionine gamma-lyase (unknown origin) | Homo sapiens | 6 | ALA4130591 | single protein format | Scientific Literature | |
2. | ALA4136612 | Binding | Inhibition of cystathionine gamma-lyase (unknown origin) assessed as reduction in cysteine formation from CPM at 40 uM using L-cystathionine incubated for 7 mins by fluorescence-based primary assay | Homo sapiens | 1 | ALA4130591 | single protein format | Scientific Literature | |
3. | ALA4136613 | Binding | Reversible inhibition of cystathionine gamma-lyase (unknown origin) assessed as reduction in cysteine formation from CPM using L-cystathionine at 50 uM incubated for 2 hrs followed by dialysis for 18 to 48 hrs by fluorescence-based primary assay | Homo sapiens | 1 | ALA4130591 | single protein format | Scientific Literature | |
4. | ALA4136614 | Binding | Inhibition of cystathionine gamma-lyase (unknown origin) assessed as reduction in H2S production at 40 uM using AzMC probe by fluorescence based assay | Homo sapiens | 1 | ALA4130591 | single protein format | Scientific Literature | |
5. | ALA4136616 | Binding | Inhibition of cystathionine gamma-lyase (unknown origin) assessed as reduction in cysteine formation from CPM using L-cystathionine pre-incubated for 15 min followed by L-cystathionine and CPM addition and measured after 7 mins by fluorescence-based primary assay | Homo sapiens | 41 | ALA4130591 | single protein format | Scientific Literature | |
6. | ALA4138487 | Binding | Inhibition of N-terminal His-tagged CSE extracted from human HepG2 cells expressed in Escherichia coli BL21 (DE3) using methylcysteine as substrate measured for 10 mins by CPM probe-based fluorescence assay | Homo sapiens | 1 | ALA4138050 | assay format | Scientific Literature | |
7. | ALA4138489 | Binding | Inhibition of N-terminal His-tagged CSE extracted from human HepG2 cells expressed in Escherichia coli BL21 (DE3) using cysteine as substrate assessed as decrease in H2S production preincubated for 3 mins in presence of lead nitrate followed by cysteine addition | Homo sapiens | 9 | ALA4138050 | assay format | Scientific Literature | |
8. | ALA4675259 | Binding | Inhibition of human CSE expressed in HEK293T cells assessed as reduction in H2S contents at 20 to 50 uM by lead acetate assay | Homo sapiens | 1 | ALA4673222 | cell-based format | Scientific Literature | |
9. | ALA4675261 | Binding | Inhibition of human CSE R119K mutant expressed in HEK293T cells assessed as reduction in H2S contents at 200 to 500 uM by lead acetate assay | Homo sapiens | 1 | ALA4673222 | cell-based format | Scientific Literature | |
10. | ALA4675262 | Binding | Inhibition of human CSE Y114F mutant expressed in HEK293T cells assessed as reduction in H2S contents at 200 to 500 uM by lead acetate assay | Homo sapiens | 1 | ALA4673222 | cell-based format | Scientific Literature | |
11. | ALA4675263 | Binding | Inhibition of human CSE R119A mutant expressed in HEK293T cells assessed as reduction in H2S contents at 200 to 500 uM by lead acetate assay | Homo sapiens | 1 | ALA4673222 | cell-based format | Scientific Literature | |
12. | ALA4675265 | Binding | Inhibition of human CSE R119K mutant expressed in HEK293T cells assessed as reduction in H2S contents | Homo sapiens | 1 | ALA4673222 | cell-based format | Scientific Literature | |
13. | ALA4675266 | Binding | Inhibition of human CSE Y114F mutant expressed in HEK293T cells assessed as reduction in H2S contents | Homo sapiens | 1 | ALA4673222 | cell-based format | Scientific Literature | |
14. | ALA4675267 | Binding | Inhibition of human CSE R119A mutant expressed in HEK293T cells assessed as reduction in H2S contents | Homo sapiens | 1 | ALA4673222 | cell-based format | Scientific Literature | |
15. | ALA4675271 | Binding | Inhibition of wild type human CSE expressed in HEK293T cells assessed as reduction in H2S contents | Homo sapiens | 1 | ALA4673222 | cell-based format | Scientific Literature | |
16. | ALA4675275 | Binding | Inhibition of human CSE expressed in mouse RAW264.7 cells assessed as reduction in amount of released H2S level at >=200 uM by lead acetate method | Mus musculus | 1 | ALA4673222 | cell-based format | Scientific Literature | |
17. | ALA4675277 | Binding | Inhibition of human CSE expressed in mouse RAW264.7 cells assessed as reduction in amount of released H2S level at 20 to 50 uM by lead acetate method | Mus musculus | 1 | ALA4673222 | cell-based format | Scientific Literature | |
18. | ALA4675288 | Binding | Competitive inhibition of human CSE using varying levels of L-Cys as substrate and fixed PLP levels | Homo sapiens | 2 | ALA4673222 | single protein format | Scientific Literature | |
19. | ALA4675289 | Binding | Effect on PLP interaction with human CSE assessed as effect on spectra of CSE-bound PLP | Homo sapiens | 1 | ALA4673222 | single protein format | Scientific Literature | |
20. | ALA4675290 | Binding | Non-competitive inhibition of human CSE using varying levels of PLP and fixed L-Cys as substrate | Homo sapiens | 1 | ALA4673222 | single protein format | Scientific Literature |