| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4256756 | B | Inhibition of NLRC4 in mouse J774A.1 cells assessed as reduction in LPS-stimulated IL-1beta levels at 10 uM incubated for 1 hr with LPS followed by (poly(dA:dT)) stimulation for 8 hrs by ELISA | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 2. | ALA4416610 | B | Inhibition of NLRC4 in mouse J774A.1 cells assessed as inhibition of LPS and poly(dA:dT)-induced IL-1beta production incubated with LPS for 1 hr followed by poly(dA:dT) addition and further incubated for 8 hrs ELISA | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 3. | ALA4818418 | B | Inhibition of NLRC4 inflammasome activation in LPS-induced mouse J744A.1 cells infected with FLS-ST pre-treated for 1 hr at 1 to 5 uM measured after 1 hr of stimulation | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 4. | ALA4833228 | B | Inhibition of NLRC4 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in IL-1beta secretion at 2 uM preincubated for 30 mins followed by Salmonella addition and measured after 4 hrs by ELISA | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 5. | ALA4833267 | B | Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in ASC polymerization at 1 to 4 uM preincubated for 30 mins followed by nigericin addition and measured after 0.5 hrs by DAPI staining based confocal scanning microscopy | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 6. | ALA4833268 | B | Inhibition of ROS production in LPS-stimulated mouse bone marrow-derived macrophages at 1 to 4 uM preincubated for 30 mins followed by nigericin addition and measured after 0.5 hrs by Western blot analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 7. | ALA5119458 | B | Inhibition of NLRC4 inflammasome activation in LPS-primed mouse BMDM cells assessed as reduction in IL-1beta secretion at 7.5 to 60 nM preincubated for 1 hr followed by FLA-ST Ultrapure stimulation by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA5119459 | B | Inhibition of NLRC4 inflammasome activation in LPS-primed mouse BMDM cells assessed as reduction in IL-1beta secretion at 7.5 to 60 nM preincubated for 1 hr followed by poly (dA/dT) stimulation by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5122309 | B | Inhibition of NLRC4 inflammasome activation in LPS-primed mouse BMDM cells assessed as reduction in LPS/ATP induced cleaved caspase 1 p20 level in supernatant preincubated for 30 mins followed by LPS addition for 3 hrs prior to ATP addition for 30 mins by Western blot analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA5140069 | B | Inhibition of NLRC4 inflammasome in LPS-primed mouse J774.A1 cells assessed as IL-1beta secretion at 10 uM preincubated for 1 hr followed by flagellin addition and measured after 6 hrs by ELISA relative to control | Mus musculus | 15 | cell-based format | Scientific Literature | ||
| 11. | ALA5140071 | B | Inhibition of NLRC4 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr followed by flagellin addition and measured after 6 hrs by ELISA | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA5164265 | B | Inhibition of NLRC4 inflammasome activation in LPS-treated mouse BMDM assessed as reduction in flagellin induced IL-1beta release at 1 uM pretreated for 15 mins followed by flagellin addition and further incubated for 16 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5164910 | B | Inhibition of NLRC4 inflammasome activation in LPS/Salmonella-treated C57BL/6 mouse bone marrow-derived macrophages assessed as reduction in cleaved IL-1 beta level in culture supernatants preincubated for 3 hrs with LPS and for 30 mins with compound prior to Salmonella typhi addition and measured after 30 mins by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5164945 | B | Inhibition of NLRC4 inflammasome activation in LPS/Salmonella-treated C57BL/6 mouse bone marrow-derived macrophages assessed as reduction in activated caspase 1(P20) level in culture supernatants preincubated for 3 hrs with LPS and for 30 mins with compound prior to Salmonella typhi addition and measured after 30 mins by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5164946 | B | Inhibition of NLRC4 inflammasome activation in LPS/Salmonella-treated C57BL/6 mouse bone marrow-derived macrophages assessed as reduction in activated caspase 1(P20) level in cell lysates preincubated for 3 hrs with LPS and for 30 mins with compound prior to Salmonella typhi addition and measured after 30 mins by Western blot analysis | Mus musculus | 1 | subcellular format | Scientific Literature | ||
| 16. | ALA5164947 | B | Inhibition of NLRC4 inflammasome activation in LPS/Salmonella-treated C57BL/6 mouse bone marrow-derived macrophages assessed as reduction in IL-1beta secretion preincubated for 3 hrs with LPS and for 30 mins with compound prior to Salmonella typhi addition and measured after 30 mins by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature |
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