# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA659307 | B | Binding affinity towards mouse Caspase-1 | 3 | ALA1146752 | single protein format | Scientific Literature | ||
2. | ALA659308 | B | Inhibitory activity against Caspase-1 using Ac-TyrValAlaAsp-amc as substrate | 15 | ALA1131550 | single protein format | Scientific Literature | ||
3. | ALA659309 | B | Binding affinity towards mouse Caspase-1 | 65 | ALA1146752 | single protein format | Scientific Literature | ||
4. | ALA659310 | B | Inhibitory activity against murine caspase-1 | 42 | ALA1136305 | single protein format | Scientific Literature | ||
5. | ALA659722 | B | Binding affinity against Murine caspase-1 (mCsp-1) | 3 | ALA1136305 | single protein format | Scientific Literature | ||
6. | ALA828404 | B | Binding affinity against mouse Caspase-1 | Mus musculus | 42 | ALA1144434 | single protein format | Scientific Literature | |
7. | ALA872165 | B | Inhibitory activity against murine Caspase-1 | Mus musculus | 26 | ALA1141033 | single protein format | Scientific Literature | |
8. | ALA1227798 | B | Inhibition of mouse ICE | Mus musculus | 5 | ALA1221254 | single protein format | Scientific Literature | |
9. | ALA3881116 | B | Inhibition of mouse recombinant ICE pre-incubated for 30 mins before Acetyl-Tyr-Val-Ala-Asp-amino-4-methylcoumarin substrate addition measured 1 hr after substrate addition by fluorescence based assay | Mus musculus | 3 | ALA3880422 | single protein format | Patent Bioactivity Data | |
10. | ALA3881121 | B | Inhibition of mouse recombinant ICE pre-incubated for 60 mins with Acetyl-Tyr-Val-Ala-Asp-amino-4-methylcoumarin substrate followed by enzyme addition by fluorescence based assay | Mus musculus | 77 | ALA3880422 | single protein format | Patent Bioactivity Data | |
11. | ALA3881122 | B | Inhibition of mouse recombinant ICE assessed as ratio of irreversible rate constant K3 to dissociation constant of the reversible binding step Ki pre-incubated for 60 mins with Acetyl-Tyr-Val-Ala-Asp-amino-4-methylcoumarin substrate followed by enzyme addition by fluorescence based assay | Mus musculus | 77 | ALA3880422 | single protein format | Patent Bioactivity Data | |
12. | ALA4621835 | B | Inhibition of caspase-1 activity in LPS-primed immortalized mouse J744A.1 cells assessed as reduction in nigericin-induced GSDMD cleavage at 5 uM by Western blot analysis | Mus musculus | 1 | ALA4619791 | cell-based format | Scientific Literature | |
13. | ALA4621836 | B | Inhibition of caspase-1 activity in LPS-primed immortalized mouse J744A.1 cells assessed as reduction in nigericin-induced Ac-YVAD-pNA cleavage using Ac-YVAD-pNA as substrate at 5 uM by FAM-FLICA reagent based confocal microscopy | Mus musculus | 1 | ALA4619791 | cell-based format | Scientific Literature | |
14. | ALA4621837 | B | Inhibition of caspase-1 activity in LPS-primed immortalized mouse J744A.1 cells assessed as reduction in nigericin-induced caspase-1 cleavage at 5 uM by Western blot analysis | Mus musculus | 1 | ALA4619791 | cell-based format | Scientific Literature |