| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4119009 | B | Binding affinity to PYCR1 in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay | Homo sapiens | 1 | ALA4118021 | cell-based format | Scientific Literature | |
| 2. | ALA4387563 | B | Inhibition of 6x-His-tagged and SUMO tagged human PYCR1 expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in NADH oxidation incubated for 1 hr | Homo sapiens | 61 | ALA4385657 | cell-based format | Scientific Literature | |
| 3. | ALA4387564 | B | Inhibition of PYCR1 in human SUM159PT cells assessed as reduction proline content at 100 uM by LC-MS analysis relative to control | Homo sapiens | 1 | ALA4385657 | cell-based format | Scientific Literature | |
| 4. | ALA4387572 | B | Inhibition of PYCR1 in human SUM159PT cells assessed as reduction proline content at 1 uM by LC-MS analysis relative to control | Homo sapiens | 1 | ALA4385657 | cell-based format | Scientific Literature | |
| 5. | ALA4387579 | B | Inhibition of PYCR1 in human SUM159PT cells assessed as reduction proline content by LC-MS analysis relative to control | Homo sapiens | 1 | ALA4385657 | cell-based format | Scientific Literature | |
| 6. | ALA4387580 | B | Inhibition of PYCR1 in human SUM159PT cells assessed as reduction proline M+5 content at 5 uM incubated for 24 hrs in presence of [U-13C]-glutamine by LC-MS analysis | Homo sapiens | 1 | ALA4385657 | cell-based format | Scientific Literature | |
| 7. | ALA4387581 | B | Inhibition of PYCR1 in human MDA-MB-231 cells assessed as reduction in cell number at 10 uM in absence of proline by IncuCyte imaging system based assay relative to control | Homo sapiens | 1 | ALA4385657 | cell-based format | Scientific Literature | |
| 8. | ALA4387582 | B | Inhibition of PYCR1 in human SUM159PT cells assessed as reduction in cell number at 10 uM in absence of proline by IncuCyte imaging system based assay relative to control | Homo sapiens | 1 | ALA4385657 | cell-based format | Scientific Literature | |
| 9. | ALA4387583 | B | Inhibition of PYCR1 in human MDA-MB-231 cells assessed as reduction in cell number at 10 uM in presence of proline by IncuCyte imaging system based assay relative to control | Homo sapiens | 1 | ALA4385657 | cell-based format | Scientific Literature | |
| 10. | ALA4387584 | B | Inhibition of PYCR1 in human SUM159PT cells assessed as reduction in cell number at 10 uM in presence of proline by IncuCyte imaging system based assay relative to control | Homo sapiens | 1 | ALA4385657 | cell-based format | Scientific Literature | |
| 11. | ALA4387586 | B | Potency index, ratio of IC50 of pargyline to IC50 for test compound for inhibition of 6x-His-tagged and SUMO tagged human PYCR1 expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in NADH oxidation incubated for 1 hr | Homo sapiens | 1 | ALA4385657 | cell-based format | Scientific Literature |
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