| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4194660 | B | Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3gamma2 expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analysis | Rattus norvegicus | 4 | ALA4190374 | cell-based format | Scientific Literature | |
| 2. | ALA4194673 | B | Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3gamma2 expressed in HEK293 cell membranes up to 10 uM after 90 mins by liquid scintillation counting analysis relative to control | Rattus norvegicus | 5 | ALA4190374 | cell-based format | Scientific Literature | |
| 3. | ALA4194695 | B | Modulation of rat eGFP-fused GABA-A receptor alpha6beta3gamma2 expressed in HEK293 cells in presence of GABA by patch-clamp assay | Rattus norvegicus | 1 | ALA4190374 | cell-based format | Scientific Literature | |
| 4. | ALA4194703 | B | Modulation of rat eGFP-fused GABA-A receptor alpha6beta3gamma2 expressed in HEK293 cells up to 10 uM in presence of GABA by patch-clamp assay relative to control | Rattus norvegicus | 1 | ALA4190374 | cell-based format | Scientific Literature | |
| 5. | ALA4194712 | B | Agonist activity at rat eGFP-fused GABA-A receptor alpha6beta3gamma2 expressed in HEK293 cells assessed as ratio of I0 to GABA Imax at 10 uM in absence of GABA by patch-clamp assay | Rattus norvegicus | 2 | ALA4190374 | cell-based format | Scientific Literature | |
| 6. | ALA4194715 | B | Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3gamma2 expressed in HEK293 cell membranes after 90 mins in presence of GABA by liquid scintillation counting analysis | Rattus norvegicus | 3 | ALA4190374 | cell-based format | Scientific Literature | |
| 7. | ALA4194720 | B | Modulation of rat eGFP-fused GABA-A receptor alpha6beta3gamma2 expressed in HEK293 cells at <= 1 uM in presence of GABA by patch-clamp assay relative to control | Rattus norvegicus | 1 | ALA4190374 | cell-based format | Scientific Literature | |
| 8. | ALA4194727 | B | Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3gamma2 expressed in HEK293 cell membranes at 10 uM after 90 mins by liquid scintillation counting analysis relative to control | Rattus norvegicus | 3 | ALA4190374 | cell-based format | Scientific Literature | |
| 9. | ALA4194729 | B | Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3gamma2 expressed in HEK293 cell membranes up to 20 uM after 90 mins by liquid scintillation counting analysis relative to control | Rattus norvegicus | 1 | ALA4190374 | cell-based format | Scientific Literature | |
| 10. | ALA5250221 | B | Modulation of rat alpha6beta3gamma2 GABA A receptor expressed in Xenopus oocytes assessed as desensitization of GABA current at -80 mV holding potential at more than 300 uM by two-electrode voltage-clamp assay relative to control | Rattus norvegicus | 3 | ALA5247619 | cell-based format | Scientific Literature | |
| 11. | ALA5250222 | B | Modulation of rat alpha6beta3gamma2 GABA A receptor expressed in Xenopus oocytes assessed as reduction in desensitization at -80 mV holding potential by two-electrode voltage-clamp assay | Rattus norvegicus | 3 | ALA5247619 | cell-based format | Scientific Literature | |
| 12. | ALA5254704 | B | Positive allosteric modulation of rat recombinant GABAA alpha6beta3alpha6-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as increase in GABA-induced current amplitude at -80 mV holding potential in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay | Rattus norvegicus | 4 | ALA5252552 | cell-based format | Scientific Literature | |
| 13. | ALA5254706 | B | Positive allosteric modulation of rat recombinant GABAA alpha6beta3gamma2 receptor expressed in Xenopus laevis oocytes assessed as increase in GABA-induced current amplitude at -80 mV holding potential in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay | Rattus norvegicus | 1 | ALA5252552 | cell-based format | Scientific Literature | |
| 14. | ALA5254711 | B | Positive allosteric modulation of rat recombinant GABAA alpha6beta3alpha6-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as maximal current at -80 mV holding potential in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay | Rattus norvegicus | 1 | ALA5252552 | cell-based format | Scientific Literature | |
| 15. | ALA5254721 | B | Positive allosteric modulation of rat recombinant GABAA alpha6beta3gamma2 receptor expressed in Xenopus laevis oocytes assessed as maximal current at -80 mV holding potential in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay | Rattus norvegicus | 1 | ALA5252552 | cell-based format | Scientific Literature | |
| 16. | ALA5254722 | B | Positive allosteric modulation of rat recombinant GABAA alpha6beta3alpha6-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as increase in GABA-induced current amplitude at -80 mV holding potential under more potent phase in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay | Rattus norvegicus | 7 | ALA5252552 | cell-based format | Scientific Literature | |
| 17. | ALA5254723 | B | Positive allosteric modulation of rat recombinant GABAA alpha6beta3alpha6-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as increase in GABA-induced current amplitude at -80 mV holding potential under less potent phase in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay | Rattus norvegicus | 7 | ALA5252552 | cell-based format | Scientific Literature | |
| 18. | ALA5254724 | B | Positive allosteric modulation of rat recombinant GABAA alpha6beta3alpha6-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as maximal current at -80 mV holding potential under more potent phase in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay relative to control | Rattus norvegicus | 7 | ALA5252552 | cell-based format | Scientific Literature | |
| 19. | ALA5254725 | B | Positive allosteric modulation of rat recombinant GABAA alpha6beta3alpha6-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as maximal current under less potent phase in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay relative to control | Rattus norvegicus | 7 | ALA5252552 | cell-based format | Scientific Literature | |
| 20. | ALA5254730 | B | Positive allosteric modulation of rat recombinant GABAA alpha6beta3gamma2 receptor expressed in Xenopus laevis oocytes assessed as increase in GABA-induced current amplitude at -80 mV holding potential under more potent phase in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay | Rattus norvegicus | 1 | ALA5252552 | cell-based format | Scientific Literature |
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