| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4194667 | B | Displacement of [3H]EBOB from rat GABA-A receptor alpha1beta3gamma2 expressed in HEK293 cell membranes at 10 uM after 90 mins by liquid scintillation counting analysis relative to control | Rattus norvegicus | 2 | ALA4190374 | cell-based format | Scientific Literature | |
| 2. | ALA4194677 | B | Displacement of [3H]EBOB from rat GABA-A receptor alpha1beta3gamma2 expressed in HEK293 cell membranes at 20 uM after 90 mins by liquid scintillation counting analysis relative to control | Rattus norvegicus | 1 | ALA4190374 | cell-based format | Scientific Literature | |
| 3. | ALA4194690 | B | Modulation of rat eGFP-fused GABA-A receptor alpha1beta3gamma2 expressed in HEK293 cells in presence of GABA by patch-clamp assay | Rattus norvegicus | 1 | ALA4190374 | cell-based format | Scientific Literature | |
| 4. | ALA4194698 | B | Modulation of rat eGFP-fused GABA-A receptor alpha1beta3gamma2 expressed in HEK293 cells up to 10 uM in presence of GABA by patch-clamp assay relative to control | Rattus norvegicus | 1 | ALA4190374 | cell-based format | Scientific Literature | |
| 5. | ALA4194706 | B | Agonist activity at rat eGFP-fused GABA-A receptor alpha1beta3gamma2 expressed in HEK293 cells assessed as ratio of I0 to GABA Imax at 10 uM in absence of GABA by patch-clamp assay | Rattus norvegicus | 2 | ALA4190374 | cell-based format | Scientific Literature | |
| 6. | ALA4194722 | B | Modulation of rat eGFP-fused GABA-A receptor alpha1beta3gamma2 expressed in HEK293 cells at <= 1 uM in presence of GABA by patch-clamp assay relative to control | Rattus norvegicus | 1 | ALA4190374 | cell-based format | Scientific Literature | |
| 7. | ALA4219591 | B | Displacement of [3H]-flunitrazepam from recombinant rat GABAA receptor alpha1beta3gamma2S expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method | Rattus norvegicus | 1 | ALA4219030 | cell-based format | Scientific Literature | |
| 8. | ALA5254701 | B | Positive allosteric modulation of rat recombinant GABAA alpha1beta3alpha1-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as increase in GABA-induced current amplitude at -80 mV holding potential in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay | Rattus norvegicus | 1 | ALA5252552 | cell-based format | Scientific Literature | |
| 9. | ALA5254705 | B | Positive allosteric modulation of rat recombinant GABAA alpha1beta3gamma2 receptor expressed in Xenopus laevis oocytes assessed as increase in GABA-induced current amplitude at -80 mV holding potential in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay | Rattus norvegicus | 1 | ALA5252552 | cell-based format | Scientific Literature | |
| 10. | ALA5254707 | B | Positive allosteric modulation of rat recombinant GABAA alpha1beta3alpha1-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced current at -80 mV holding potential at 1 uM in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay | Rattus norvegicus | 1 | ALA5252552 | cell-based format | Scientific Literature | |
| 11. | ALA5254709 | B | Positive allosteric modulation of rat recombinant GABAA alpha1beta3gamma2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced current at -80 mV holding potential at 1 uM in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay | Rattus norvegicus | 1 | ALA5252552 | cell-based format | Scientific Literature | |
| 12. | ALA5254710 | B | Positive allosteric modulation of rat recombinant GABAA alpha1beta3alpha1-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as maximal current at -80 mV holding potential in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay | Rattus norvegicus | 1 | ALA5252552 | cell-based format | Scientific Literature | |
| 13. | ALA5254717 | B | Positive allosteric modulation of rat recombinant GABAA gamma2beta3alpha1 receptor expressed in Xenopus laevis oocytes assessed as activation of maximal current at -80 mV holding potential in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay | Rattus norvegicus | 1 | ALA5252552 | cell-based format | Scientific Literature | |
| 14. | ALA5254720 | B | Positive allosteric modulation of rat recombinant GABAA alpha1beta3gamma2 receptor expressed in Xenopus laevis oocytes assessed as maximal current at -80 mV holding potential in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay | Rattus norvegicus | 1 | ALA5252552 | cell-based format | Scientific Literature | |
| 15. | ALA5254734 | B | Positive allosteric modulation of rat recombinant GABAA alpha1beta3alpha1-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as increase in GABA-induced current amplitude at -80 mV holding potential under less potent phase in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay | Rattus norvegicus | 1 | ALA5252552 | cell-based format | Scientific Literature | |
| 16. | ALA5254735 | B | Positive allosteric modulation of rat recombinant GABAA alpha1beta3alpha1-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as maximal current at -80 mV holding potential under less potent phase in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay relative to control | Rattus norvegicus | 1 | ALA5252552 | cell-based format | Scientific Literature | |
| 17. | ALA5254736 | B | Positive allosteric modulation of rat recombinant GABAA alpha1beta3gamma2 receptor expressed in Xenopus laevis oocytes assessed as increase in GABA-induced current amplitude at -80 mV holding potential under less potent phase in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay | Rattus norvegicus | 1 | ALA5252552 | cell-based format | Scientific Literature | |
| 18. | ALA5254737 | B | Positive allosteric modulation of rat recombinant GABAA alpha1beta3gamma2 receptor expressed in Xenopus laevis oocytes assessed as maximal current at -80 mV holding potential under less potent phase in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay relative to control | Rattus norvegicus | 1 | ALA5252552 | cell-based format | Scientific Literature | |
| 19. | ALA5254751 | B | Positive allosteric modulation of rat recombinant GABAA alpha1beta3gamma2 receptor expressed in Xenopus laevis oocytes assessed as maximal efficacy at -80 mV holding potential at 30 nM in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay | Rattus norvegicus | 1 | ALA5252552 | cell-based format | Scientific Literature | |
| 20. | ALA5254752 | B | Positive allosteric modulation of rat recombinant GABAA alpha1beta3gamma2 receptor expressed in Xenopus laevis oocytes assessed as maximal efficacy at -80 mV holding potential at 10 nM in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay | Rattus norvegicus | 1 | ALA5252552 | cell-based format | Scientific Literature |
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