| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4147120 | B | Inhibition of RANKL/RANK protein-protein interaction in mouse RAW264.7 cells assessed as reduction in RANKL-stimulated NF-kB signaling pathway activation by measuring decrease in IkBalpha phosphorylation after 2 hrs by immunoblot assay | Mus musculus | 1 | ALA4145488 | cell-based format | Scientific Literature | |
| 2. | ALA4397812 | B | Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclastogenesis by measuring reduction in NFATc1 mRNA level measured after 3 days by Trizol-reagent-based qRT-PCR analysis | Mus musculus | 1 | ALA4396880 | protein format | Scientific Literature | |
| 3. | ALA4397813 | B | Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclastogenesis by measuring reduction in TRAP mRNA level measured after 3 days by Trizol-reagent-based qRT-PCR analysis | Mus musculus | 1 | ALA4396880 | protein format | Scientific Literature | |
| 4. | ALA4397814 | B | Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclast differentiation by measuring decrease in multinucleated TRAP+ cells at 10 uM supplemented with fresh medium containing compounds every 2 days for 5 to 6 days by TRAP staining-based microscopic analysis relative to control | Mus musculus | 1 | ALA4396880 | cell-based format | Scientific Literature | |
| 5. | ALA4397815 | B | Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclast differentiation by measuring decrease in multinucleated TRAP+ cells at 5 uM supplemented with fresh medium containing compounds every 2 days for 5 to 6 days by TRAP staining-based microscopic analysis relative to control | Mus musculus | 1 | ALA4396880 | cell-based format | Scientific Literature | |
| 6. | ALA4397816 | B | Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclast differentiation by measuring decrease in multinucleated TRAP+ cells supplemented with fresh medium containing compounds every 2 days for 5 to 6 days by TRAP staining-based microscopic analysis | Mus musculus | 5 | ALA4396880 | cell-based format | Scientific Literature | |
| 7. | ALA4397817 | B | Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclastogenesis by measuring reduction in TRAP activity at 5 uM measured after 3 days by colorimetric assay relative to control | Mus musculus | 37 | ALA4396880 | protein format | Scientific Literature | |
| 8. | ALA4397818 | B | Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclastogenesis by measuring reduction in cathepsin K mRNA level at 2.5 uM measured after 3 days by Trizol-reagent-based qRT-PCR analysis | Mus musculus | 1 | ALA4396880 | protein format | Scientific Literature | |
| 9. | ALA4397819 | B | Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclastogenesis by measuring reduction in cathepsin K mRNA level measured after 3 days by Trizol-reagent-based qRT-PCR analysis | Mus musculus | 1 | ALA4396880 | protein format | Scientific Literature | |
| 10. | ALA4397824 | B | Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclast differentiation by measuring decrease in multinucleated TRAP+ cells at 5 uM supplemented with fresh medium containing compounds every 2 days for 5 to 6 days by TRAP staining-based microscopic analysis | Mus musculus | 4 | ALA4396880 | cell-based format | Scientific Literature | |
| 11. | ALA4397825 | B | Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclast differentiation by measuring decrease in nuclei size of F-actin ring formation at 5 uM supplemented with fresh medium containing compounds every 2 days for 5 to 6 days by rhodamine phalloidin/DAPI staining-based microscopic analysis | Mus musculus | 4 | ALA4396880 | protein format | Scientific Literature | |
| 12. | ALA4397826 | B | Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclast differentiation by measuring decrease in nuclei number of F-actin ring formation at 5 uM supplemented with fresh medium containing compounds every 2 days for 5 to 6 days by rhodamine phalloidin/DAPI staining-based microscopic analysis | Mus musculus | 4 | ALA4396880 | protein format | Scientific Literature | |
| 13. | ALA4397828 | B | Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced bone resorption at 1 to 5 uM measured after 2 days by toluidine blue staining-based confocal microscopic analysis | Mus musculus | 1 | ALA4396880 | protein format | Scientific Literature | |
| 14. | ALA4397830 | B | Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclastogenesis by measuring reduction in TRAP mRNA level at 2.5 uM measured after 3 days by Trizol-reagent-based qRT-PCR analysis | Mus musculus | 1 | ALA4396880 | protein format | Scientific Literature | |
| 15. | ALA4397831 | B | Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclastogenesis by measuring reduction in NFATc1 mRNA level at 2.5 uM measured after 3 days by Trizol-reagent-based qRT-PCR analysis | Mus musculus | 1 | ALA4396880 | protein format | Scientific Literature | |
| 16. | ALA4397832 | B | Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclastogenesis by measuring reduction in NFATc1 expression measured after 3 days by Western blot analysis | Mus musculus | 1 | ALA4396880 | assay format | Scientific Literature | |
| 17. | ALA4397833 | B | Inhibition of RANKL-RANK protein-protein interaction in C57/BL6 mouse bone marrow macrophage assessed as suppression of M-CSF/mRANKL-induced osteoclastogenesis by measuring reduction in c-fos expression measured after 3 days by Western blot analysis | Mus musculus | 1 | ALA4396880 | assay format | Scientific Literature |
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