| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4221434 | B | Inhibition of HSP90beta/Cdc37 interaction in human A549 cells assessed as upregulation of HSP90beta expression at 5 to 10 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4219101 | cell-based format | Scientific Literature | |
| 2. | ALA4381180 | B | Inhibition of His-tagged HSP90/GST-tagged Cdc37 (unknown origin) protein-protein interaction at 100 uM measured after 1 hr by HTRF assay relative to control | Homo sapiens | 36 | ALA4376883 | protein complex format | Scientific Literature | |
| 3. | ALA4381212 | B | Inhibition of HSP90-CDC37 protein-protein interaction in human HCT116 cells measured after 12 hrs by coimmunoprecipitation-based Western blot assay | Homo sapiens | 1 | ALA4376883 | cell-based format | Scientific Literature | |
| 4. | ALA4381213 | B | Inhibition of HSP90-CDC37 protein-protein interaction in human HCT116 cells up to 1 uM measured after 12 hrs by coimmunoprecipitation-based Western blot assay | Homo sapiens | 1 | ALA4376883 | cell-based format | Scientific Literature | |
| 5. | ALA4381215 | B | Inhibition of HSP90-CDC37 protein-protein interaction in human HCT116 cells assessed as reduction in CDK4 expression up to 10 uM measured after 12 hrs by coimmunoprecipitation-based Western blot assay | Homo sapiens | 1 | ALA4376883 | cell-based format | Scientific Literature | |
| 6. | ALA4381216 | B | Inhibition of HSP90-CDC37 protein-protein interaction in human HCT116 cells assessed as reduction in CDK4 expression by Western blot analysis | Homo sapiens | 1 | ALA4376883 | cell-based format | Scientific Literature | |
| 7. | ALA4381217 | B | Inhibition of HSP90-CDC37 protein-protein interaction in human HCT116 cells assessed as reduction in CDK6 expression by Western blot analysis | Homo sapiens | 1 | ALA4376883 | cell-based format | Scientific Literature | |
| 8. | ALA4381218 | B | Inhibition of HSP90-CDC37 protein-protein interaction in human HCT116 cells assessed as down regulation of cyclin D1 expression by Western blot analysis | Homo sapiens | 1 | ALA4376883 | cell-based format | Scientific Literature | |
| 9. | ALA4381219 | B | Inhibition of HSP90-CDC37 protein-protein interaction in human HCT116 cells assessed as down regulation of cyclin D3 expression by Western blot analysis | Homo sapiens | 1 | ALA4376883 | cell-based format | Scientific Literature | |
| 10. | ALA4381220 | B | Inhibition of HSP90-CDC37 protein-protein interaction in human HCT116 cells assessed as up regulation of p21 expression by Western blot analysis | Homo sapiens | 1 | ALA4376883 | cell-based format | Scientific Literature | |
| 11. | ALA4381221 | B | Inhibition of HSP90-CDC37 protein-protein interaction in human HCT116 cells assessed as up regulation of p27 expression by Western blot analysis | Homo sapiens | 1 | ALA4376883 | cell-based format | Scientific Literature | |
| 12. | ALA5232303 | B | Disruption of His-tagged full length HSP90 (unknown origin)/GST-tagged Cdc37 (unknown origin) at 50 uM measured after 1 hr by HTRF method | Homo sapiens | 16 | ALA5230144 | protein complex format | Scientific Literature | |
| 13. | ALA5232304 | B | Disruption of His-tagged full length HSP90 (unknown origin)/GST-tagged Cdc37 (unknown origin) measured after 1 hr by HTRF method | Homo sapiens | 6 | ALA5230144 | protein complex format | Scientific Literature | |
| 14. | ALA5232314 | B | Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells at 200 nM measured after 48 hrs by immunoprecipitation method | Homo sapiens | 1 | ALA5230144 | cell-based format | Scientific Literature | |
| 15. | ALA5232315 | B | Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as decrease of phosphorylated AKT expression measured by Western blot analysis | Homo sapiens | 1 | ALA5230144 | cell-based format | Scientific Literature | |
| 16. | ALA5232316 | B | Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as decrease of CDK4 expression measured by Western blot assay | Homo sapiens | 1 | ALA5230144 | cell-based format | Scientific Literature | |
| 17. | ALA5232317 | B | Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as increase of Bax/Bcl2 ratio at 100 nM measured by Western blot assay | Homo sapiens | 1 | ALA5230144 | cell-based format | Scientific Literature | |
| 18. | ALA5232318 | B | Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as increase of Bax/Bcl2 ratio at 200 nM measured by Western blot assay | Homo sapiens | 1 | ALA5230144 | cell-based format | Scientific Literature | |
| 19. | ALA5232319 | B | Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as increase of cytochrome C release at 100 nM measured by Western blot assay | Homo sapiens | 1 | ALA5230144 | cell-based format | Scientific Literature | |
| 20. | ALA5232320 | B | Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as increase of cytochrome C release at 200 nM measured by Western blot assay | Homo sapiens | 1 | ALA5230144 | cell-based format | Scientific Literature |
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