# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4143121 | B | Inhibition of LPS-induced MD2/TLR4 interaction in ICR mouse peritoneal macrophages at 10 uM preincubated for 30 mins followed by LPS stimulation measured after 15 mins by immunoprecipitation analysis | Mus musculus | 1 | ALA4138215 | protein complex format | Scientific Literature | |
2. | ALA4304841 | B | Inhibition of MD2-TLR4 protein-protein interaction in ICR mouse peritoneal macrophages assessed as reduction in LPS-induced IL-6 production at 10 uM preincubated for 2 hrs followed by LPS-stimulation and measured after 22 hrs by ELISA relative to control | Mus musculus | 17 | ALA4304739 | protein complex format | Scientific Literature | |
3. | ALA4304842 | B | Inhibition of MD2-TLR4 protein-protein interaction in ICR mouse peritoneal macrophages assessed as reduction in LPS-induced TNFalpha production at 10 uM preincubated for 2 hrs followed by LPS-stimulation and measured after 22 hrs by ELISA relative to control | Mus musculus | 15 | ALA4304739 | protein complex format | Scientific Literature | |
4. | ALA4304843 | B | Inhibition of MD2-TLR4 protein-protein interaction in ICR mouse peritoneal macrophages assessed as reduction in LPS-induced IL-6 production preincubated for 2 hrs followed by LPS-stimulation and measured after 22 hrs by ELISA | Mus musculus | 4 | ALA4304739 | protein complex format | Scientific Literature | |
5. | ALA4304844 | B | Inhibition of MD2-TLR4 protein-protein interaction in ICR mouse peritoneal macrophages assessed as reduction in LPS-induced TNFalpha production preincubated for 2 hrs followed by LPS-stimulation and measured after 22 hrs by ELISA | Mus musculus | 4 | ALA4304739 | protein complex format | Scientific Literature | |
6. | ALA4304846 | B | Inhibition of MD2-TLR4 protein-protein interaction in ICR mouse peritoneal macrophages assessed as reduction in LPS-induced NFkappaB p65 activation in nuclear fraction by Western blot analysis | Mus musculus | 1 | ALA4304739 | protein complex format | Scientific Literature | |
7. | ALA4304852 | B | Inhibition of MD2-TLR4 protein-protein interaction in ICR mouse peritoneal macrophages assessed as reduction in LPS-stimulated MD2-TLR4 dimerization at 10 uM preincubated for 30 mins followed by LPS stimulation and measured after 15 mins by co-immunoprecipitation method | Mus musculus | 1 | ALA4304739 | protein complex format | Scientific Literature | |
8. | ALA4304854 | B | Inhibition of FITC-labeled LPS binding to MD2-TLR4 complex in ICR mouse peritoneal macrophages measured after 30 mins by flow cytometry | Mus musculus | 1 | ALA4304739 | protein complex format | Scientific Literature | |
9. | ALA4326675 | B | Inhibition of TLR4/MD2 interaction in LPS-induced mouse RAW264.7 at 20 uM measured after 30 mins by co-immunoprecipitation method | Mus musculus | 1 | ALA4325844 | cell-based format | Scientific Literature | |
10. | ALA4400188 | B | Inhibition of TLR4/MD2 interaction in LPS-induced C57BL/6 mouse primary peritoneal macrophages followed by LPS-stimulation and measured after 10 mins by co-immunoprecipitation method | Mus musculus | 1 | ALA4396951 | protein complex format | Scientific Literature |