# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4219434 | Binding | Induction of cereblon-mediated ikaros degradation in human DF15 cells expressing ePL-tagged ikaros after 4 hrs by luminometric analysis | Homo sapiens | 3 | ALA4219026 | cell-based format | Scientific Literature | |
2. | ALA4219436 | Binding | Induction of cereblon-mediated ikaros degradation in human DF15 cells at 0.1 to 10 uM after 5 hrs by immunoblot analysis | Homo sapiens | 2 | ALA4219026 | cell-based format | Scientific Literature | |
3. | ALA4219438 | Binding | Induction of cereblon-mediated ikaros degradation in human OPM2 cells at 0.1 to 10 uM after 5 hrs by immunoblot analysis | Homo sapiens | 2 | ALA4219026 | cell-based format | Scientific Literature | |
4. | ALA4219440 | Binding | Induction of cereblon-mediated ikaros degradation in human DF15 cells at 0.01 to 1 uM after 5 hrs by immunoblot analysis | Homo sapiens | 1 | ALA4219026 | cell-based format | Scientific Literature | |
5. | ALA4219442 | Binding | Induction of cereblon-mediated ikaros degradation in human OPM2 cells at 0.01 to 1 uM after 5 hrs by immunoblot analysis | Homo sapiens | 1 | ALA4219026 | cell-based format | Scientific Literature | |
6. | ALA4312363 | Binding | Protac activity at CRBN/IKZF1 in human MM1S cells assessed as IKZF1 degradation at 100 nM measured after 6 hrs by Western blot analysis | Homo sapiens | 1 | ALA4311941 | cell-based format | Scientific Literature | |
7. | ALA4312368 | Binding | Protac activity at CRBN/IKZF1 in human MM1S cells assessed as IKZF1 degradation at 100 nM measured after 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4311941 | cell-based format | Scientific Literature | |
8. | ALA4312370 | Binding | Protac activity at CRBN/IKZF1 in human MM1S cells assessed as IKZF1 degradation measured after 6 hrs by Western blot analysis | Homo sapiens | 1 | ALA4311941 | cell-based format | Scientific Literature | |
9. | ALA4312399 | Binding | Protac activity at CRBN/IKZF1 in human MM1S cells assessed as IKZF1 degradation at 100 nM measured after 6 hrs in presence of E3 ligase ligand pomalidomide by Western blot analysis | Homo sapiens | 1 | ALA4311941 | cell-based format | Scientific Literature | |
10. | ALA4312400 | Binding | Protac activity at CRBN/IKZF1 in human MM1S cells assessed as IKZF1 degradation at 100 nM measured after 6 hrs in presence of HDAC6 inhibitor Next-A by Western blot analysis | Homo sapiens | 1 | ALA4311941 | cell-based format | Scientific Literature | |
11. | ALA4312404 | Binding | Protac activity at CRBN/IKZF1 in human MM1S cells assessed as IKZF1 degradation at 100 nM measured after 6 hrs in presence of NAE inhibitor MLN 4924 by Western blot analysis | Homo sapiens | 1 | ALA4311941 | cell-based format | Scientific Literature | |
12. | ALA4374299 | Binding | Protac activity at CRBN/ IKZF1 in human MM1S cells assessed as reduction in IKZF1 degradation at 0.001 to 0.01 uM after 16 hrs by Western blot analysis | Homo sapiens | 1 | ALA4373656 | cell-based format | Scientific Literature | |
13. | ALA4374300 | Binding | Protac activity at CRBN/ IKZF1 in human MM1S cells assessed as IKZF1 degradation at 0.1 to 10 uM after 16 hrs by Western blot analysis relative to tubulin | Homo sapiens | 3 | ALA4373656 | cell-based format | Scientific Literature | |
14. | ALA4374302 | Binding | Protac activity at CRBN/ IKZF1 in human MM1S cells assessed as Bax protein expression at 0.1 to 10 uM after 16 hrs by Western blot analysis relative to tubulin | Homo sapiens | 1 | ALA4373656 | cell-based format | Scientific Literature | |
15. | ALA4374303 | Binding | Protac activity at CRBN/ IKZF1 in human MM1S cells assessed as IKZF1 degradation by measuring IKZF1/tubulin ratio at 1 uM after 16 hrs by Western blot analysis relative to tubulin | Homo sapiens | 6 | ALA4373656 | cell-based format | Scientific Literature | |
16. | ALA4374304 | Binding | Protac activity at CRBN/ IKZF1 in human MM1S cells assessed as IKZF1 degradation by measuring IKZF1/tubulin ratio at 0.1 uM after 16 hrs by Western blot analysis relative to tubulin | Homo sapiens | 7 | ALA4373656 | cell-based format | Scientific Literature | |
17. | ALA4374305 | Binding | Protac activity at CRBN/ IKZF1 in human MM1S cells assessed as CRBN degradation at 100 nM to 1 uM after 16 hrs by Western blot analysis | Homo sapiens | 5 | ALA4373656 | cell-based format | Scientific Literature | |
18. | ALA4400874 | Binding | Induction of CRBN ubiquitin ligase-mediated IKZF1 degradation in human NCI-H929 cells up to 1000 nM by immunoblotting analysis | Homo sapiens | 5 | ALA4400516 | cell-based format | Scientific Literature | |
19. | ALA4400882 | Binding | Induction of CRBN ubiquitin ligase-mediated IKZF1 degradation in human U266 cells up to 1000 nM measured after 12 hrs by immunoblotting analysis | Homo sapiens | 2 | ALA4400516 | cell-based format | Scientific Literature | |
20. | ALA4619454 | Binding | Protac activity at cereblon/IKZF1 in human SW480 cells assessed as induction of IKZF1 degradation at 5 to 10 uM incubated for 24 hrs by Western blot assay | Homo sapiens | 1 | ALA4616722 | cell-based format | Scientific Literature |