| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5256275 | B | Protac activity at CRBN/IKZF1 in human MOLT-4 cells assessed as induction of IKZF1 degradation assessed as maximum degradation after 24 hrs relative to control | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 2. | ALA5256276 | B | Protac activity at CRBN/IKZF1 in human MOLT-4 cells assessed as induction of IKZF1 degradation after 24 hrs | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 3. | ALA4219434 | B | Induction of cereblon-mediated ikaros degradation in human DF15 cells expressing ePL-tagged ikaros after 4 hrs by luminometric analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA4219436 | B | Induction of cereblon-mediated ikaros degradation in human DF15 cells at 0.1 to 10 uM after 5 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4219438 | B | Induction of cereblon-mediated ikaros degradation in human OPM2 cells at 0.1 to 10 uM after 5 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA4219440 | B | Induction of cereblon-mediated ikaros degradation in human DF15 cells at 0.01 to 1 uM after 5 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4219442 | B | Induction of cereblon-mediated ikaros degradation in human OPM2 cells at 0.01 to 1 uM after 5 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4312363 | B | Protac activity at CRBN/IKZF1 in human MM1S cells assessed as IKZF1 degradation at 100 nM measured after 6 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4312368 | B | Protac activity at CRBN/IKZF1 in human MM1S cells assessed as IKZF1 degradation at 100 nM measured after 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4312370 | B | Protac activity at CRBN/IKZF1 in human MM1S cells assessed as IKZF1 degradation measured after 6 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4312399 | B | Protac activity at CRBN/IKZF1 in human MM1S cells assessed as IKZF1 degradation at 100 nM measured after 6 hrs in presence of E3 ligase ligand pomalidomide by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4312400 | B | Protac activity at CRBN/IKZF1 in human MM1S cells assessed as IKZF1 degradation at 100 nM measured after 6 hrs in presence of HDAC6 inhibitor Next-A by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4312404 | B | Protac activity at CRBN/IKZF1 in human MM1S cells assessed as IKZF1 degradation at 100 nM measured after 6 hrs in presence of NAE inhibitor MLN 4924 by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4374299 | B | Protac activity at CRBN/ IKZF1 in human MM1S cells assessed as reduction in IKZF1 degradation at 0.001 to 0.01 uM after 16 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4374300 | B | Protac activity at CRBN/ IKZF1 in human MM1S cells assessed as IKZF1 degradation at 0.1 to 10 uM after 16 hrs by Western blot analysis relative to tubulin | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 16. | ALA4374302 | B | Protac activity at CRBN/ IKZF1 in human MM1S cells assessed as Bax protein expression at 0.1 to 10 uM after 16 hrs by Western blot analysis relative to tubulin | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4374303 | B | Protac activity at CRBN/ IKZF1 in human MM1S cells assessed as IKZF1 degradation by measuring IKZF1/tubulin ratio at 1 uM after 16 hrs by Western blot analysis relative to tubulin | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 18. | ALA4374304 | B | Protac activity at CRBN/ IKZF1 in human MM1S cells assessed as IKZF1 degradation by measuring IKZF1/tubulin ratio at 0.1 uM after 16 hrs by Western blot analysis relative to tubulin | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 19. | ALA4374305 | B | Protac activity at CRBN/ IKZF1 in human MM1S cells assessed as CRBN degradation at 100 nM to 1 uM after 16 hrs by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 20. | ALA4400874 | B | Induction of CRBN ubiquitin ligase-mediated IKZF1 degradation in human NCI-H929 cells up to 1000 nM by immunoblotting analysis | Homo sapiens | 5 | cell-based format | Scientific Literature |
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