# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4150533 | Binding | Induction of CRBN-mediated CDK8 degradation in human Jurkat cells at 0.1 to 1 uM measured after 6 to 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA4145630 | cell-based format | Scientific Literature | |
2. | ALA4150534 | Binding | Induction of CRBN-mediated CDK8 degradation in human Jurkat cells at 1 uM measured after 6 to 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA4145630 | cell-based format | Scientific Literature | |
3. | ALA4150535 | Binding | Induction of CRBN-mediated CDK8 degradation in human Jurkat cells at 0.1 to 10 uM measured after 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA4145630 | cell-based format | Scientific Literature | |
4. | ALA4150536 | Binding | Induction of CRBN-mediated CDK8 degradation in wild-type human MOLT4 cells at 5 uM measured after 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA4145630 | assay format | Scientific Literature | |
5. | ALA4150538 | Binding | Induction of CRBN-mediated CDK8 degradation in human Jurkat cells up to 10 uM measured after 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA4145630 | cell-based format | Scientific Literature | |
6. | ALA4150539 | Binding | Induction of CRBN-mediated CDK8 degradation in human Jurkat cells at 1 uM measured after 6 hrs in presence of proteasome inhibitor bortezomib by immunoblot analysis | Homo sapiens | 1 | ALA4145630 | cell-based format | Scientific Literature | |
7. | ALA4150540 | Binding | Induction of CRBN-mediated CDK8 degradation in human Jurkat cells at 1 uM measured after 6 hrs in presence of neddylation inhibitor MLN4924 by immunoblot analysis | Homo sapiens | 1 | ALA4145630 | cell-based format | Scientific Literature | |
8. | ALA4150541 | Binding | Induction of CRBN-mediated CDK8 degradation in human Jurkat cells at 1 uM measured after 6 hrs in presence of N-((3S,17S)-17-(isoquinolin-7-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)-Nmethyl-1-((2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-amide by immunoblot analysis | Homo sapiens | 1 | ALA4145630 | cell-based format | Scientific Literature | |
9. | ALA4150542 | Binding | Induction of CRBN-mediated CDK8 degradation in human Jurkat cells at 1 uM measured after 6 hrs in presence of lenalidomide by immunoblot analysis | Homo sapiens | 1 | ALA4145630 | cell-based format | Scientific Literature | |
10. | ALA4150544 | Binding | Induction of CRBN-mediated CDK8 degradation in wild-type human Jurkat cells at 1 to 10 uM measured after 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA4145630 | cell-based format | Scientific Literature | |
11. | ALA4150545 | Binding | Induction of CRBN-mediated CDK8 degradation in wild-type human Jurkat cells at 20 uM measured after 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA4145630 | cell-based format | Scientific Literature | |
12. | ALA4822287 | Binding | Protac activity at CDK8/CRBN in human HEK293 cells assessed as degradation of CDK8 at 0.01 to 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4819106 | cell-based format | Scientific Literature | |
13. | ALA4822296 | Binding | Protac activity at CDK8/CRBN in human HEK293 cells assessed as degradation of CDK8 at 1 uM measured upto 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4819106 | cell-based format | Scientific Literature |