| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5249932 | B | Protac activity at CRBN/HDAC6 in human MM1.S assessed as degradation of HDAC6 incubated for 24 hrs by immunoblot assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA5249933 | B | Protac activity at CRBN/HDAC6 in human MM1.S assessed as degradation of HDAC6 incubated for 6 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4124653 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as decrease in HDAC6 levels at 5 uM after 12 hrs by immunoblotting analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 4. | ALA4124657 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as decrease in HDAC6 levels after 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4124658 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as decrease in HDAC6 levels at 10 uM after 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4124662 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as increase in acetylated alpha-tubulin levels at 1.1 to 10 uM after 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4124663 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as increase in acetylated alpha-tubulin levels at 2 uM after 2 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4124664 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as decrease in HDAC6 levels at 2 uM after 2 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4124665 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as decrease in HDAC6 levels at 2 uM preincubated for 1 hr with proteosome-inhibitor MG132 followed by compound addition for 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4124666 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as decrease in HDAC6 levels at 2 uM preincubated for 1 hr with CRBN ligand pomalidomide followed by compound addition for 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4124667 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as increase in acetylated alpha-tubulin levels at 2 uM preincubated for 1 hr with proteosome-inhibitor MG132 followed by compound addition for 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4124668 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as increase in acetylated alpha-tubulin levels at 2 uM at 2 uM preincubated for 1 hr with CRBN ligand pomalidomide followed by compound addition for 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4124669 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as decrease in HDAC6 levels at 2 uM preincubated for 1 hr with 1 uM pan-HDAC inhibitor N-hydroxy-8-(2-(4-methoxybenzylidene)hydrazinyl)-8-oxooctanamide followed by compound addition for 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4124670 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as decrease in HDAC6 levels at 2 uM preincubated for 1 hr with 100 nM pan-HDAC inhibitor N-hydroxy-8-(2-(4-methoxybenzylidene)hydrazinyl)-8-oxooctanamide followed by compound addition for 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4124671 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as increase in acetylated alpha-tubulin levels at 2 uM preincubated for 1 hr with 100 nM pan-HDAC inhibitor N-hydroxy-8-(2-(4-methoxybenzylidene)hydrazinyl)-8-oxooctanamide followed by compound addition for 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4124673 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MM1S cells assessed as decrease in HDAC6 levels at =>80 nM after 6 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4124674 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MM1S cells assessed as increase in acetylated alpha-tubulin levels at =>80 nM after 6 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4312360 | B | Protac activity at CRBN/HDAC6 in human MM1S cells assessed as HDAC6 degradation at 100 nM measured after 6 hrs by ELISA relative to control | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 19. | ALA4312361 | B | Protac activity at CRBN/HDAC6 in human MM1S cells assessed as HDAC6 degradation at 10 nM measured after 6 hrs by ELISA relative to control | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 20. | ALA4312362 | B | Protac activity at CRBN/HDAC6 in human MM1S cells assessed as HDAC6 degradation at 10 to 100 nM measured after 6 hrs by Western blot analysis | Homo sapiens | 7 | cell-based format | Scientific Literature |
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