# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4124654 | B | Induction of CRBN ubiquitin ligase-mediated HDAC1 degradation in human MCF7 cells assessed as decrease in HDAC1 levels at 5 uM after 12 hrs by immunoblotting analysis | Homo sapiens | 4 | ALA4118247 | cell-based format | Scientific Literature | |
2. | ALA4124659 | B | Induction of CRBN ubiquitin ligase-mediated HDAC1 degradation in human MCF7 cells assessed as decrease in HDAC1 levels at 10 uM after 12 hrs by immunoblotting analysis | Homo sapiens | 1 | ALA4118247 | cell-based format | Scientific Literature | |
3. | ALA4124672 | B | Induction of CRBN ubiquitin ligase-mediated HDAC1 degradation in human MCF7 cells assessed as increase in acetylated H3 levels at 2 uM after 12 hrs by immunoblotting analysis | Homo sapiens | 1 | ALA4118247 | cell-based format | Scientific Literature | |
4. | ALA4312372 | B | Protac activity at CRBN/HDAC1 in human MM1S cells assessed as HDAC1 degradation measured after 6 hrs by Western blot analysis | Homo sapiens | 1 | ALA4311941 | cell-based format | Scientific Literature | |
5. | ALA4312377 | B | Protac activity at CRBN/HDAC1 in human MM1S cells assessed as HDAC1 degradation at 100 nM measured up to 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA4311941 | cell-based format | Scientific Literature | |
6. | ALA4312410 | B | Protac activity at CRBN/HDAC1 in human MM1S cells assessed as HDAC1 degradation at 100 nM measured after 6 hrs in presence of proteasome inhibitor MG132 by Western blot analysis | Homo sapiens | 1 | ALA4311941 | cell-based format | Scientific Literature | |
7. | ALA4312411 | B | Protac activity at CRBN/HDAC1 in human MM1S cells assessed as HDAC1 degradation at 100 nM measured after 6 hrs in presence of proteasome inhibitor bortezomib by Western blot analysis | Homo sapiens | 1 | ALA4311941 | cell-based format | Scientific Literature | |
8. | ALA5137986 | B | PROTAC activity at CRBN/HDAC1 (unknown origin) by cell based assay | Homo sapiens | 1 | ALA5136981 | cell-based format | Scientific Literature |