| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4219424 | B | Induction of cereblon-mediated Sirt2 degradation in human HeLa cells at 10 uM after 1 to 6 hrs by Western blot method | Homo sapiens | 1 | ALA4219025 | cell-based format | Scientific Literature | |
| 2. | ALA4219425 | B | Induction of cereblon-mediated EGFP-fused Sirt2 (unknown origin) degradation expressed in human HeLa cells at 10 uM after 4 hrs in presence of 2-(4,6-dimethylpyrimidin-2-ylthio)-N-(5-(3-((1-(2-methoxyethyl)-1H-1,2,3-triazol-4-yl)methoxy)benzyl)thiazol-2-yl)acetamide and proteosome inhibitor MG132 by Western blot method | Homo sapiens | 1 | ALA4219025 | cell-based format | Scientific Literature | |
| 3. | ALA4219426 | B | Induction of cereblon-mediated Sirt2 degradation in human HeLa cells at 0.05 to 5 uM after 4 hrs by Western blot method | Homo sapiens | 2 | ALA4219025 | cell-based format | Scientific Literature | |
| 4. | ALA4219427 | B | Induction of cereblon-mediated Sirt2 degradation in human HeLa cells at 10 uM after 2 hrs by Western blot method | Homo sapiens | 1 | ALA4219025 | cell-based format | Scientific Literature | |
| 5. | ALA4219428 | B | Induction of cereblon-mediated EGFP-fused Sirt2 (unknown origin) degradation expressed in human HeLa cells at 10 uM after 4 hrs by Hoechst 33342 staining-based fluorescent microscopic method | Homo sapiens | 1 | ALA4219025 | cell-based format | Scientific Literature | |
| 6. | ALA4219429 | B | Induction of cereblon-mediated EGFP-fused Sirt2 degradation in human HeLa cells assessed as increase in tubulin acetlyation at 10 uM after 4 hrs by DAPI dye-based immunofluorescent microscopic analysis | Homo sapiens | 1 | ALA4219025 | cell-based format | Scientific Literature | |
| 7. | ALA4219430 | B | Induction of cereblon-mediated Sirt2 degradation in human HeLa cells after 4 hrs by Western blot method | Homo sapiens | 1 | ALA4219025 | cell-based format | Scientific Literature | |
| 8. | ALA4731766 | B | Protac activity at CRBN/SIRT2 in human MCF7 cells assessed as SIRT2 degradation at 5 to 10 uM after 48 hrs by immunoblot analysis | Homo sapiens | 3 | ALA4725483 | cell-based format | Scientific Literature | |
| 9. | ALA4731767 | B | Protac activity at CRBN/SIRT2 in human BT549 cells assessed as SIRT2 degradation at 5 to 10 uM after 48 hrs by immunoblot analysis | Homo sapiens | 3 | ALA4725483 | cell-based format | Scientific Literature | |
| 10. | ALA4731770 | B | Protac activity at CRBN/SIRT2 in human MDA-MB-231 cells assessed as SIRT2 degradation after 48 hrs by immunoblot analysis | Homo sapiens | 2 | ALA4725483 | cell-based format | Scientific Literature | |
| 11. | ALA4731771 | B | Protac activity at CRBN/SIRT2 in human MDA-MB-468 cells assessed as SIRT2 degradation after 48 hrs by immunoblot analysis | Homo sapiens | 2 | ALA4725483 | cell-based format | Scientific Literature | |
| 12. | ALA4731772 | B | Protac activity at CRBN/SIRT2 in human MCF7 cells assessed as SIRT2 degradation at 0.5 uM after 48 hrs by immunoblot analysis | Homo sapiens | 1 | ALA4725483 | cell-based format | Scientific Literature | |
| 13. | ALA4731773 | B | Protac activity at CRBN/SIRT2 in human MCF7 cells assessed as SIRT2 degradation at 10 uM by immunoblot analysis | Homo sapiens | 2 | ALA4725483 | cell-based format | Scientific Literature | |
| 14. | ALA4731774 | B | Protac activity at CRBN/SIRT2 in human MCF7 cells assessed as SIRT2 degradation at 50 uM after 48 hrs by immunoblot analysis | Homo sapiens | 1 | ALA4725483 | cell-based format | Scientific Literature | |
| 15. | ALA4731775 | B | Protac activity at CRBN/SIRT2 in human MCF7 cells assessed as SIRT2 degradation at 25 uM by immunoblot analysis | Homo sapiens | 2 | ALA4725483 | cell-based format | Scientific Literature | |
| 16. | ALA4731776 | B | Protac activity at CRBN/SIRT2 in human MCF7 cells assessed as SIRT2 degradation at 5 uM by immunoblot analysis | Homo sapiens | 2 | ALA4725483 | cell-based format | Scientific Literature | |
| 17. | ALA4731777 | B | Protac activity at CRBN/SIRT2 in human MCF7 cells assessed as SIRT2 degradation at 5 uM preincubated with proteasome inhibitior MG132 for 2 hrs followed by compound addition measured after 16 hrs by immunoblot analysis | Homo sapiens | 1 | ALA4725483 | cell-based format | Scientific Literature | |
| 18. | ALA4731778 | B | Protac activity at CRBN/SIRT2 in human HEK293T cells stably expressing flag-tagged K-Ras4a assessed as inhibition of SIRT2 defatty-acylation at 10 uM incubated for 42 hrs followed by Alkyne-14 addition and measured after 6 hrs by immunoprecipitation based assay | Homo sapiens | 1 | ALA4725483 | cell-based format | Scientific Literature | |
| 19. | ALA4731779 | B | Protac activity at CRBN/SIRT2 in human MCF7 cells assessed as inhibition of SIRT2 deacetylation by measuring increase in acetylated-alpha tubulin level at 5 uM measured after 12 hrs by DAPI staining based immunofluorescence microscopic analysis | Homo sapiens | 2 | ALA4725483 | cell-based format | Scientific Literature | |
| 20. | ALA4731780 | B | Protac activity at CRBN/SIRT2 in human MCF7 cells assessed as inhibition of SIRT2 deacetylation by measuring increase in acetylated-alpha tubulin level at 10 uM measured after 12 hrs by DAPI staining based immunofluorescence microscopic analysis | Homo sapiens | 2 | ALA4725483 | cell-based format | Scientific Literature |
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