| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4219423 | B | Induction of cereblon-mediated Sirt1 degradation in human HeLa cells at 10 uM after 1 to 6 hrs by Western blot method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA4731764 | B | Protac activity at CRBN/SIRT1 in human MCF7 cells assessed as SIRT1 degradation at 5 to 10 uM after 48 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 3. | ALA4731765 | B | Protac activity at CRBN/SIRT1 in human BT549 cells assessed as SIRT1 degradation at 5 to 10 uM after 48 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4731783 | B | Protac activity at CRBN/SIRT1 in human HEK293T cells stably expressing flag-tagged K-Ras4a-G12V assessed as inhibition of SIRT2 defatty-acylation at 1 uM incubated for 48 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4731791 | B | Protac activity at CRBN/SIRT1 in human HEK293T cells assessed as abundance ratio at 5 uM incubated for 16 hrs by TMT global proteomics assay relative to DMSO | Homo sapiens | 1 | cell-based format | Scientific Literature |
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