# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4190499 | B | Proteolysis targeting chimera activity in human K562 cells assessed as induction of cereblon-mediated delivery of BCR-ABL for protein degradation by proteasome at 1 uM after 24 hrs by immuno blot analysis relative to control | Homo sapiens | 2 | ALA4190166 | cell-based format | Scientific Literature | |
2. | ALA4382069 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as reduction in BCR-ABL protein levels at 100 nM incubated for 36 hrs by Western blot analysis | Homo sapiens | 2 | ALA4376901 | cell-based format | Scientific Literature | |
3. | ALA4382081 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as reduction in BCR-ABL protein levels pre-treated with ABL inhibitor dasatinib followed by compound addition at 250 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
4. | ALA4382083 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as reduction in BCR-ABL protein levels at 50 to 250 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
5. | ALA4382085 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as reduction in BCR-ABL protein levels pre-treated with lenalidomide followed by compound addition at 250 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
6. | ALA4382087 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as reduction in BCR-ABL protein levels pre-treated with NEDD8-activating enzyme (NAE) inhibitor MLN4924 followed by compound addition at 250 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
7. | ALA4382089 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as reduction in BCR-ABL protein levels incubated for 36 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
8. | ALA4382091 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as reduction in BCR-ABL protein levels at 500 nM incubated for 36 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
9. | ALA4382093 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as reduction in BCR-ABL protein levels at 250 nM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
10. | ALA4382095 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as reduction in BCR-ABL protein levels at 250 nM incubated for 10 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
11. | ALA4382097 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as reduction in BCR-ABL protein levels at 250 nM incubated for 32 hrs by Western blot analysis | Homo sapiens | 2 | ALA4376901 | cell-based format | Scientific Literature | |
12. | ALA4382100 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as reduction in BCR-ABL protein levels incubated for 24 hrs followed by exposure to UV-C light every 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
13. | ALA4382102 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as reduction in BCR-ABL protein levels incubated for 24 hrs followed by exposure to white light up to 24 hrs hrs by Western blot analysis | Homo sapiens | 2 | ALA4376901 | cell-based format | Scientific Literature | |
14. | ALA4619594 | B | Protac activity at Cereblon/BCR/ABL in human K562 cells assessed as induction of BCR-ABL degradation incubated for 32 to 48 hrs by Western blot analysis | Homo sapiens | 20 | ALA4616725 | cell-based format | Scientific Literature | |
15. | ALA4619596 | B | Protac activity at Cereblon/BCR/ABL T315I mutant (unknown origin) expressed in mouse BaF3 cells assessed as reduction in BCR-ABL T315I mutant protein levels at 3 to 30000 nM incubated for 32 hrs by Western blot analysis | Homo sapiens | 2 | ALA4616725 | cell-based format | Scientific Literature | |
16. | ALA4619598 | B | Protac activity at Cereblon/BCR/ABL T315I mutant (unknown origin) expressed in mouse BaF3 cells assessed as reduction in BCR-ABL T315I mutant driven cell viability incubated for 3 days by CCK8 assay | Homo sapiens | 16 | ALA4616725 | cell-based format | Scientific Literature | |
17. | ALA4619599 | B | Protac activity at Cereblon/BCR/ABL E255K mutant (unknown origin) expressed in human HeLa cells cells assessed as reduction in BCR-ABL E255K mutant protein levels at 10 to 10000 nM incubated for 32 hrs by Western blot analysis | Homo sapiens | 1 | ALA4616725 | cell-based format | Scientific Literature | |
18. | ALA4619600 | B | Protac activity at Cereblon/BCR/ABL H396R mutant (unknown origin) expressed in human HeLa cells cells assessed as reduction in BCR-ABL H396R mutant protein levels at 10 to 10000 nM incubated for 32 hrs by Western blot analysis | Homo sapiens | 1 | ALA4616725 | cell-based format | Scientific Literature | |
19. | ALA4619601 | B | Protac activity at Cereblon/BCR/ABL V468F mutant (unknown origin) expressed in human HeLa cells cells assessed as reduction in BCR-ABL V468F mutant protein levels at 10 to 10000 nM incubated for 32 hrs by Western blot analysis | Homo sapiens | 1 | ALA4616725 | cell-based format | Scientific Literature | |
20. | ALA4619602 | B | Protac activity at Cereblon/BCR/ABL T315I mutant (unknown origin) expressed in mouse BaF3 cells assessed as reduction in BCR-ABL T315I mutant protein levels at 3 to 30000 nM incubated for 48 hrs by Western blot analysis | Homo sapiens | 3 | ALA4616725 | cell-based format | Scientific Literature |