| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5250388 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as increase in BCR-ABL degradation at 50 nM by Western blotting analysis | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 2. | ALA5250389 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as increase in BCR-ABL degradation at 500 nM by Western blotting analysis | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 3. | ALA5250390 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as increase in BCR-ABL degradation at 5 nM by Western blotting analysis | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 4. | ALA5250391 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as increase in BCR-ABL degradation at 100 nM by Western blotting analysis | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 5. | ALA5250395 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as increase in BCR-ABL degradation incubated for 16 hrs by Western blotting analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA5250396 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as increase in c-ABL degradation incubated for 16 hrs by Western blotting analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA5250397 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as increase in BCR-ABL degradation at 0.3 to 100 nM incubated for 16 hrs by Western blotting analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA5250401 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of BCR-ABL degradation at 100 nM by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5250402 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as BCR-ABL turnover rate in presence of cycloheximide by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5250403 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as c-ABL turnover rate in presence of cycloheximide by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA5250404 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of BCR-ABL degradation at 100 nM pretreated with lenalidomide for 2 hrs followed by compound addition measured after 8 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA5250405 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of BCR-ABL degradation at 100 nM pretreated with asciminib for 2 hrs followed by compound addition measured after 8 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5250406 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of BCR-ABL degradation at 100 nM pretreated with MLN4924 for 2 hrs followed by compound addition measured after 8 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5250407 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of c-ABL degradation at 100 nM pretreated with lenalidomide for 2 hrs followed by compound addition measured after 8 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5250408 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of c-ABL degradation at 100 nM pretreated with asciminib for 2 hrs followed by compound addition measured after 8 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5250409 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of c-ABL degradation at 100 nM pretreated with MLN4924 for 2 hrs followed by compound addition measured after 8 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5250410 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of BCR-ABL degradation at 100 nM pretreated with MG132 for 2 hrs followed by compound addition measured after 8 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5250414 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as increase in BCR-ABL degradation at 100 nM incubated for 6 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5250415 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as increase in BCR-ABL degradation at 100 nM incubated for 6 hrs followed by compound washout measured after 4 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA5250416 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as increase in BCR-ABL degradation at 100 nM incubated for 6 hrs followed by compound washout measured upto 96 hrs by Western blotting analysis | Homo sapiens | 2 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!