# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4026936 | B | Proteolysis targeting chimera activity in human THP1 cells assessed as induction of VHL-mediated delivery of RIPK2 for protein degradation by proteasome by measuring drug level causing 50% cellular protein depletion incubated for 16 hrs by Western blotting method | Homo sapiens | 1 | ALA4024761 | cell-based format | Scientific Literature | |
2. | ALA4190484 | B | Proteolysis targeting chimera activity in human THP1 cells assessed as induction of VHL-mediated delivery of RIPK2 for protein degradation by proteasome by measuring drug level causing 50% substrate depletion incubated for 16 hrs by Western blot method | Homo sapiens | 1 | ALA4190166 | cell-based format | Scientific Literature | |
3. | ALA4190485 | B | Proteolysis targeting chimera activity in human THP1 cells assessed as induction of VHL-mediated delivery of RIPK2 for protein degradation by proteasome at >10 nM incubated for 16 hrs by Western blot method relative to control | Homo sapiens | 1 | ALA4190166 | cell-based format | Scientific Literature | |
4. | ALA4349406 | B | Protac activity against VHL/RIPK2 in human THP-1 cells assessed as induction of RIPK2 protein degradation at 10 nM relative to control | Homo sapiens | 1 | ALA4346721 | cell-based format | Scientific Literature | |
5. | ALA4349407 | B | Protac activity against VHL/RIPK2 in human THP-1 cells assessed as induction of RIPK2 protein degradation | Homo sapiens | 1 | ALA4346721 | cell-based format | Scientific Literature | |
6. | ALA4388598 | B | Protac activity at VHL/RIPK2 in human THP1 cells assessed as induction of RIPK2 protein degradation incubated for 16 hrs by Western blot analysis | Homo sapiens | 1 | ALA4387721 | cell-based format | Scientific Literature | |
7. | ALA4388599 | B | Protac activity at VHL/RIPK2 in human THP1 cells assessed as induction of RIPK2 protein degradation at 10 nM incubated for 16 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA4387721 | cell-based format | Scientific Literature | |
8. | ALA4415998 | B | Protac activity against VHL/RIPK2 in human K562 cells assessed as reduction in RIPK2 protein levels at 1 to 100 nM incubated for 16 hrs by by Western blot analysis | Homo sapiens | 1 | ALA4414590 | cell-based format | Scientific Literature | |
9. | ALA4832924 | B | Protac activity at VHL/RIPK2 in human THP-1 cells assessed as induction of RIPK2 degradation by measuring decrease in protein level incubated for 16 hrs by Western blot analysis | Homo sapiens | 1 | ALA4831517 | cell-based format | Scientific Literature | |
10. | ALA4832927 | B | Protac activity at VHL/RIPK2 in human whole blood assessed as inhibition of MDP-induced TNFalpha production by ELISA | Homo sapiens | 1 | ALA4831517 | tissue-based format | Scientific Literature |