# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4190487 | B | Proteolysis targeting chimera activity in human MCF7 cells assessed as induction of VHL-mediated delivery of ERRalpha for protein degradation by proteasome by measuring drug level causing 50% substrate depletion incubated for 24 hrs by Western blot method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
2. | ALA4305576 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation at 30 nM incubated for 4 hrs by Western blot analysis relative to control | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
3. | ALA4305577 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation at 10 nM incubated for 4 hrs by Western blot analysis relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
4. | ALA4305578 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation at 100 nM incubated for 4 hrs by Western blot analysis relative to control | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
5. | ALA4305579 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation at 300 nM incubated for 4 hrs by Western blot analysis relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA4305580 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
7. | ALA4305583 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation incubated for 0.5 to 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA4305584 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation incubated for 48 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA4305585 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as decrease in MCAD protein expression level at 100 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA4305586 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as decrease in PDK4 protein expression level at 100 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
11. | ALA4305587 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as decrease in ATP5B protein expression level at 100 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
12. | ALA4305588 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation at 3.0 nM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
13. | ALA4305589 | B | Protac activity at VHL/ERRalpha in epoxomicin pre-treated human MDA-MB-231 cells assessed as induction of ERalpha degradation at 30 nM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
14. | ALA4305590 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation at 1 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
15. | ALA4388596 | B | Protac activity at VHL/ERRalpha in epoxomicin pre-treated human MCF7 cells assessed as induction of ERRalpha protein degradation incubated for 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
16. | ALA4388597 | B | Protac activity at VHL/ERRalpha in epoxomicin pre-treated human MCF7 cells assessed as induction of ERRalpha protein degradation at 1 uM incubated for 8 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
17. | ALA5137704 | B | Protac activity at VHL/ERRalpha in human MCF7 cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
18. | ALA5137705 | B | Protac activity at VHL/ERRalpha in human MCF7 cells relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
19. | ALA5246066 | B | Protac activity at VHL/ERRalpha in human MCF7 cells assessed as maximum degradation | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
20. | ALA5246301 | B | Protac activity at VHL/ERRalpha in human MCF7 cells | Homo sapiens | 1 | cell-based format | Scientific Literature |