# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4190487 | Binding | Proteolysis targeting chimera activity in human MCF7 cells assessed as induction of VHL-mediated delivery of ERRalpha for protein degradation by proteasome by measuring drug level causing 50% substrate depletion incubated for 24 hrs by Western blot method | Homo sapiens | 1 | ALA4190166 | cell-based format | Scientific Literature | |
2. | ALA4305576 | Binding | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation at 30 nM incubated for 4 hrs by Western blot analysis relative to control | Homo sapiens | 12 | ALA4304753 | cell-based format | Scientific Literature | |
3. | ALA4305577 | Binding | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation at 10 nM incubated for 4 hrs by Western blot analysis relative to control | Homo sapiens | 2 | ALA4304753 | cell-based format | Scientific Literature | |
4. | ALA4305578 | Binding | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation at 100 nM incubated for 4 hrs by Western blot analysis relative to control | Homo sapiens | 12 | ALA4304753 | cell-based format | Scientific Literature | |
5. | ALA4305579 | Binding | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation at 300 nM incubated for 4 hrs by Western blot analysis relative to control | Homo sapiens | 2 | ALA4304753 | cell-based format | Scientific Literature | |
6. | ALA4305580 | Binding | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4304753 | cell-based format | Scientific Literature | |
7. | ALA4305583 | Binding | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation incubated for 0.5 to 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4304753 | cell-based format | Scientific Literature | |
8. | ALA4305584 | Binding | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation incubated for 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA4304753 | cell-based format | Scientific Literature | |
9. | ALA4305585 | Binding | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as decrease in MCAD protein expression level at 100 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4304753 | cell-based format | Scientific Literature | |
10. | ALA4305586 | Binding | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as decrease in PDK4 protein expression level at 100 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4304753 | cell-based format | Scientific Literature | |
11. | ALA4305587 | Binding | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as decrease in ATP5B protein expression level at 100 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4304753 | cell-based format | Scientific Literature | |
12. | ALA4305588 | Binding | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation at 3.0 nM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4304753 | cell-based format | Scientific Literature | |
13. | ALA4305589 | Binding | Protac activity at VHL/ERRalpha in epoxomicin pre-treated human MDA-MB-231 cells assessed as induction of ERalpha degradation at 30 nM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4304753 | cell-based format | Scientific Literature | |
14. | ALA4305590 | Binding | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation at 1 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 2 | ALA4304753 | cell-based format | Scientific Literature | |
15. | ALA4388596 | Binding | Protac activity at VHL/ERRalpha in epoxomicin pre-treated human MCF7 cells assessed as induction of ERRalpha protein degradation incubated for 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA4387721 | cell-based format | Scientific Literature | |
16. | ALA4388597 | Binding | Protac activity at VHL/ERRalpha in epoxomicin pre-treated human MCF7 cells assessed as induction of ERRalpha protein degradation at 1 uM incubated for 8 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA4387721 | cell-based format | Scientific Literature | |
17. | ALA5137704 | Binding | Protac activity at VHL/ERRalpha in human MCF7 cells | Homo sapiens | 1 | ALA5136974 | cell-based format | Scientific Literature | |
18. | ALA5137705 | Binding | Protac activity at VHL/ERRalpha in human MCF7 cells relative to control | Homo sapiens | 1 | ALA5136974 | cell-based format | Scientific Literature | |
19. | ALA5246066 | Binding | Protac activity at VHL/ERRalpha in human MCF7 cells assessed as maximum degradation | Homo sapiens | 1 | ALA5244252 | cell-based format | Scientific Literature | |
20. | ALA5246301 | Binding | Protac activity at VHL/ERRalpha in human MCF7 cells | Homo sapiens | 1 | ALA5244258 | cell-based format | Scientific Literature |