# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4190491 | B | Proteolysis targeting chimera activity in human 22Rv1 cells assessed as induction of VHL-mediated delivery of BRD2 for protein degradation by proteasome by measuring drug level causing 50% substrate depletion incubated for 16 hrs by Western blot method | Homo sapiens | 1 | ALA4190166 | cell-based format | Scientific Literature | |
2. | ALA4349409 | B | Protac activity against VHL/BRD2 in human 22Rvl cells assessed as induction of BRD2 protein degradation by reverse phase protein array analysis | Homo sapiens | 1 | ALA4346721 | cell-based format | Scientific Literature | |
3. | ALA4349415 | B | Protac activity against VHL/BRD2 (unknown origin) assessed as induction of BRD4 protein degradation by cell based assay | Homo sapiens | 1 | ALA4346721 | cell-based format | Scientific Literature | |
4. | ALA4388593 | B | Protac activity at VHL/BRD2 in human 22Rv1 cells assessed as induction of BRD2 protein degradation incubated for 16 hrs by Western blot analysis | Homo sapiens | 1 | ALA4387721 | cell-based format | Scientific Literature | |
5. | ALA5036174 | B | Protac activity at VHL/Brd2 in HEK293 cells assessed as Brd2 degradation after 4 hrs by Western blotting analysis | Homo sapiens | 8 | ALA5034040 | cell-based format | Scientific Literature | |
6. | ALA5054769 | B | Bump and hole PROTAC activity at BromoTag-Brd2/VHL-bound E3 ligase in HEK293 cells assessed as Brd2 degradation at 0.001 to 10 uM measured after 6 hrs by Western blot analysis | Homo sapiens | 11 | ALA5053531 | cell-based format | Scientific Literature | |
7. | ALA5054772 | B | Bump and hole PROTAC activity at BromoTag-Brd2/VHL-bound E3 ligase in HEK293 cells assessed as Brd2 degradation by measuring protein half life measured after 6 hrs by Western blot analysis | Homo sapiens | 3 | ALA5053531 | cell-based format | Scientific Literature | |
8. | ALA5054794 | B | Bump and hole PROTAC activity at BromoTag-Brd2/VHL-bound E3 ligase in HEK293 cells assessed as Brd2 degradation at 1 uM measured after 6 hrs by Western blot analysis | Homo sapiens | 3 | ALA5053531 | cell-based format | Scientific Literature | |
9. | ALA5054795 | B | Bump and hole PROTAC activity at BromoTag-Brd2/VHL-bound E3 ligase in HEK293 cells assessed as Brd2 degradation measured after 6 hrs by Western blot analysis | Homo sapiens | 11 | ALA5053531 | cell-based format | Scientific Literature | |
10. | ALA5054796 | B | Bump and hole PROTAC activity at BromoTag-Brd2/VHL-bound E3 ligase in HEK293 cells assessed as maximal Brd2 degradation measured after 6 hrs by Western blot analysis | Homo sapiens | 11 | ALA5053531 | cell-based format | Scientific Literature | |
11. | ALA5231281 | B | PROTAC activity at BRD2/VHL in human 22Rv1 cells assessed as protein degradation measured after 16 hrs | Homo sapiens | 1 | ALA5230109 | cell-based format | Scientific Literature | |
12. | ALA5243387 | B | Protac activity at BRD2/VHL-bound E3 ligase in human 22Rv1 cells assessed as reduction c-Myc level incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5241114 | cell-based format | Scientific Literature |