# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4152833 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated EML4-ALK fusion protein degradation in human SU-DHL1 cells assessed as reduction in STAT3 phosphorylation at Y705 residue after 16 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
2. | ALA4152834 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated EML4-ALK fusion protein degradation in human NCI-H2228 cells assessed as reduction in STAT3 phosphorylation at Y705 residue after 16 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
3. | ALA4152843 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated EML4-ALK fusion protein degradation in human NCI-H2228 cells assessed as reduction in EML4-ALK fusion protein levels after 16 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
4. | ALA4152844 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated EML4-ALK fusion protein degradation in human NCI-H2228 cells assessed as reduction in EML4-ALK fusion protein levels at 100 nM after 16 hrs by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
5. | ALA4152845 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated EML4-ALK fusion protein degradation in human SU-DHL1 cells assessed as reduction in ALK autophosphorylation at Y1507 residue at 30 nM after 2 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA4152846 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated EML4-ALK fusion protein degradation in human SU-DHL1 cells assessed as reduction in STAT3 phosphorylation at Y705 residue at 30 nM after 2 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
7. | ALA4152847 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated EML4-ALK fusion protein degradation in human SU-DHL1 cells assessed as reduction in NPM-ALK fusion protein levels at 30 nM measured up to 4 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
8. | ALA4152848 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated EML4-ALK fusion protein degradation in human NCI-H2228 cells assessed as reduction in EML4-ALK fusion protein levels at 60 nM after 8 to 24 hrs hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
9. | ALA4152849 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated EML4-ALK fusion protein degradation assessed as inhibition of ALK autophosphorylation at Y1507 residue in human NCI-H2228 cells at 60 nM after 8 to 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
10. | ALA4152866 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated EML4-ALK fusion protein degradation in human SU-DHL1 cells assessed as reduction in NPM-ALK fusion protein levels at 30 nM after 16 to 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
11. | ALA4152867 | B | Induction of CRL4/CRBN ubiquitin ligase-mediated EML4-ALK fusion protein degradation in human NCI-H2228 cells assessed as reduction in STAT3 phosphorylation at Y705 residue at 60 nM after 8 to 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
12. | ALA4736199 | B | Protac activity at CRBN/EML4-ALK fusion protein in human NCI-H3122 cells assessed as induction of EML4-ALK fusion protein degradation measured after 8 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
13. | ALA4736200 | B | Protac activity at CRBN/EML4-ALK fusion protein in human NCI-H3122 cells assessed as induction of EML4-ALK fusion protein degradation at 50 nM measured after 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
14. | ALA4736201 | B | Protac activity at CRBN/EML4-ALK fusion protein in human NCI-H3122 cells assessed as induction of EML4-ALK fusion protein degradation at 100 nM measured after 16 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
15. | ALA4736202 | B | Protac activity at CRBN/EML4-ALK fusion protein in human NCI-H3122 cells assessed as reduction in ALK phosphorylation at 100 nM measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
16. | ALA4736203 | B | Protac activity at CRBN/EML4-ALK fusion protein in human NCI-H3122 cells assessed as reduction in STAT3 phosphorylation at 100 nM measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
17. | ALA4736205 | B | Protac activity at CRBN/EML4-ALK fusion protein in human NCI-H3122 cells assessed as induction of EML4-ALK fusion protein degradation measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
18. | ALA4736206 | B | Protac activity at CRBN/EML4-ALK fusion protein in human NCI-H3122 cells assessed as reduction in ALK phosphorylation measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
19. | ALA4736207 | B | Protac activity at CRBN/EML4-ALK fusion protein in human NCI-H3122 cells assessed as reduction in STAT3 phosphorylation measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
20. | ALA4736208 | B | Protac activity at CRBN/EML4-ALK fusion protein in human NCI-H3122 cells assessed as induction of EML4-ALK fusion protein degradation at 100 nM by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |