| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4219435 | B | Induction of cereblon-mediated aiolos degradation in human DF15 cells expressing ePL-tagged aiolos after 4 hrs by luminometric analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 2. | ALA4219437 | B | Induction of cereblon-mediated aiolos degradation in human DF15 cells at 0.1 to 10 uM after 5 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 3. | ALA4219439 | B | Induction of cereblon-mediated aiolos degradation in human OPM2 cells at 0.1 to 10 uM after 5 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4219441 | B | Induction of cereblon-mediated aiolos degradation in human DF15 cells at 0.01 to 1 uM after 5 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4219443 | B | Induction of cereblon-mediated aiolos degradation in human OPM2 cells at 0.01 to 1 uM after 5 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4312364 | B | Protac activity at CRBN/IKZF3 in human MM1S cells assessed as IKZF3 degradation at 100 nM measured after 6 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4312369 | B | Protac activity at CRBN/IKZF3 in human MM1S cells assessed as IKZF3 degradation at 100 nM measured after 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4312371 | B | Protac activity at CRBN/IKZF3 in human MM1S cells assessed as IKZF3 degradation measured after 6 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4312380 | B | Protac activity at CRBN/IKZF3 in human MM1S cells assessed as IKZF3 degradation at 100 nM incubated for 6 hrs followed by compound washout and measured after 12 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4312401 | B | Protac activity at CRBN/IKZF3 in human MM1S cells assessed as IKZF3 degradation at 100 nM measured after 6 hrs in presence of HDAC6 inhibitor Next-A by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4312402 | B | Protac activity at CRBN/IKZF3 in human MM1S cells assessed as IKZF3 degradation at 100 nM measured after 6 hrs in presence of E3 ligase ligand pomalidomide by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4312405 | B | Protac activity at CRBN/IKZF3 in human MM1S cells assessed as IKZF3 degradation at 100 nM measured after 6 hrs in presence of NAE inhibitor MLN 4924 by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4366977 | B | Inhibition of CRBN-mediated IKFZ3 degradation in human OPM2 cells at 100 uM measured after 24 hrs by Western blot analysis relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 14. | ALA4366981 | B | Inhibition of CRBN-mediated IKFZ3 degradation in human OPM2 cells measured after 24 hrs by Western blot analysis | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 15. | ALA4400891 | B | Induction of CRBN ubiquitin ligase-mediated IKZF3 degradation in human NCI-H929 cells up to 1000 nM by immunoblotting analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 16. | ALA4400899 | B | Induction of CRBN ubiquitin ligase-mediated IKZF3 degradation in human U266 cells up to 1000 nM measured after 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4619470 | B | Protac activity at cereblon/IKZF3 in human SW480 cells assessed as induction of IKZF1 degradation at 5 to 10 uM incubated for 24 hrs by Western blot assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4628555 | B | Induction of CRBN-mediated pLOC-ePL-tagged aiolos (unknown origin) degradation in human DF15 cells assessed as minimum protein remaining incubated for 4 hrs by luminescence based beta-galactosidase enzyme fragmentation complementation assay | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
| 19. | ALA4628556 | B | Induction of CRBN-mediated pLOC-ePL-tagged aiolos (unknown origin) degradation in human DF15 cells assessed as minimum protein remaining up to 10 uM incubated for 4 hrs by luminescence based beta-galactosidase enzyme fragmentation complementation assay relative to control | Homo sapiens | 39 | cell-based format | Scientific Literature | ||
| 20. | ALA4628569 | B | Induction of CRBN-mediated pLOC-ePL-tagged aiolos (unknown origin) degradation in human DF15 cells assessed as minimum protein remaining at 0.00001 to 0.1 uM incubated for 45 to 180 mins by luminescence based beta-galactosidase enzyme fragmentation complementation assay | Homo sapiens | 2 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!