# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4257019 | B | Binding affinity to N-terminal GST tagged CNK PH domain (unknown origin) by SPR spectroscopy | Homo sapiens | 21 | assay format | Patent Bioactivity Data | ||
2. | ALA4257022 | B | Competitive inhibition of CNK1 (unknown origin) binding to PIP3 (unknown origin) at 50 uM by SPR spectroscopy | Homo sapiens | 19 | assay format | Patent Bioactivity Data | ||
3. | ALA4257039 | B | Inhibition of CNKSR1 in human NSCLC cells expressing mutant KRAS assessed as potentiation of erlotinib-induced inhibition of cell growth incubated for 72 hrs by MTS assay | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
4. | ALA4257040 | B | Inhibition of CNKSR1 in human NCI-H1792 cells expressing mutant KRAS assessed as inhibition of active RalA protein | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
5. | ALA4257041 | B | Inhibition of CNKSR1 in human NCI-H1792 cells expressing mutant KRAS assessed as inhibition of active RalB protein | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
6. | ALA4257042 | B | Inhibition of CNKSR1 in human NCI-H1792 cells expressing mutant KRAS assessed as inhibition of active Rho protein | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
7. | ALA4257043 | B | Inhibition of CNKSR1 in human NCI-H1573 cells expressing mutant KRAS assessed as inhibition of active RalA protein | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
8. | ALA4257044 | B | Inhibition of CNKSR1 in human NCI-H1573 cells expressing mutant KRAS assessed as inhibition of active RalB protein | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
9. | ALA4257045 | B | Inhibition of CNKSR1 in human NCI-H1573 cells expressing mutant KRAS assessed as inhibition of active Rho protein | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
10. | ALA4257046 | B | Inhibition of CNKSR1 in human NSCLC cells expressing wild type KRAS assessed as inhibition of active Rho protein at 10 uM incubated for 2 to 48 hrs | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
11. | ALA4257047 | B | Inhibition of CNKSR1 in human NSCLC cells expressing wild type KRAS assessed as inhibition of active RalB protein at 10 uM incubated for 2 to 48 hrs | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
12. | ALA4257048 | B | Inhibition of CNKSR1 in human NSCLC cells expressing wild type KRAS assessed as inhibition of active RalA protein at 10 uM incubated for 2 to 48 hrs | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
13. | ALA4257049 | B | Inhibition of CNKSR1 in human NCI-H1573 cells expressing mutant KRAS assessed as reduction in ERK phosphorylation at 1 to 20 uM incubated for 24 hrs | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
14. | ALA4257050 | B | Inhibition of CNKSR1 in human NCI-H1573 cells expressing mutant KRAS assessed as reduction in EGFR phosphorylation at 1 to 20 uM incubated for 24 hrs | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
15. | ALA4257051 | B | Inhibition of CNKSR1 in human NCI-H1573 cells expressing mutant KRAS assessed as reduction in ERK phosphorylation at 3 to 30 uM incubated for 24 hrs | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
16. | ALA4257052 | B | Inhibition of CNKSR1 in human NCI-H1573 cells expressing mutant KRAS assessed as reduction in EGFR phosphorylation at 3 to 10 uM incubated for 24 hrs | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
17. | ALA4257053 | B | Inhibition of CNKSR1 in human NCI-H1573 cells expressing mutant KRAS assessed as reduction in EGFR phosphorylation at 30 uM incubated for 24 hrs | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
18. | ALA4257055 | B | Competitive inhibition of CNK1 (unknown origin) binding to PIP3 (unknown origin) by SPR spectroscopy | Homo sapiens | 3 | assay format | Patent Bioactivity Data | ||
19. | ALA4419254 | B | Binding affinity to CNKSR1 PH-domain (unknown origin) by SPR spectroscopy | Homo sapiens | 46 | single protein format | Patent Bioactivity Data | ||
20. | ALA4419265 | B | Inhibition of CNKSR1 PH-domain (unknown origin) assessed as reduction in c-RAF Ser338 phosphorylation at 25 to 50 uM by cell based Western blot analysis | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data |