| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4201166 | B | Inhibition of alpha-crystallin A Y118D mutant (unknown origin)-induced intracellular protein aggregation expressed in human HeLa cells or HLE-B3 cells at 4 uM incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control | Homo sapiens | 2 | ALA4196177 | cell-based format | Scientific Literature | |
| 2. | ALA4201187 | B | Inhibition of alpha-crystallin A Y118D mutant (unknown origin)-induced intracellular protein aggregation expressed in human HeLa cells at 4 uM incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control | Homo sapiens | 6 | ALA4196177 | cell-based format | Scientific Literature | |
| 3. | ALA4201188 | B | Inhibition of alpha-crystallin A Y118D mutant (unknown origin)-induced intracellular protein aggregation expressed in human HeLa cells at 0.4 uM incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control | Homo sapiens | 6 | ALA4196177 | cell-based format | Scientific Literature | |
| 4. | ALA4201189 | B | Inhibition of alpha-crystallin A Y118D mutant (unknown origin)-induced intracellular protein aggregation expressed in human HLE-B3 cells at 4 uM incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control | Homo sapiens | 6 | ALA4196177 | cell-based format | Scientific Literature | |
| 5. | ALA4201190 | B | Inhibition of alpha-crystallin A Y118D mutant (unknown origin)-induced intracellular protein aggregation expressed in human HLE-B3 cells at 0.4 uM incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control | Homo sapiens | 6 | ALA4196177 | cell-based format | Scientific Literature | |
| 6. | ALA4201191 | B | Induction of redissolving of aggregated alpha-crystallin A R116C mutant (unknown origin) at 200 uM incubated for 24 hrs by ThT-fluorescence based assay | Homo sapiens | 2 | ALA4196177 | single protein format | Scientific Literature | |
| 7. | ALA4201192 | B | Induction of redissolving of aggregated alpha-crystallin A R116H mutant (unknown origin) at 200 uM incubated for 24 hrs by ThT-fluorescence based assay | Homo sapiens | 2 | ALA4196177 | single protein format | Scientific Literature | |
| 8. | ALA4201193 | B | Induction of redissolving of aggregated alpha-crystallin A Y118D mutant (unknown origin) at 200 uM incubated for 24 hrs by ThT-fluorescence based assay | Homo sapiens | 2 | ALA4196177 | single protein format | Scientific Literature | |
| 9. | ALA4201198 | B | Induction of redissolving of aggregated alpha-crystallin A Y118D mutant (unknown origin) incubated for 24 hrs by ThT-fluorescence based assay | Homo sapiens | 1 | ALA4196177 | single protein format | Scientific Literature | |
| 10. | ALA4201200 | B | Induction of redissolving of aggregated alpha-crystallin A R116C mutant (unknown origin) at 200 uM incubated for 24 hrs by transmission-electron-microscopy | Homo sapiens | 2 | ALA4196177 | single protein format | Scientific Literature | |
| 11. | ALA4201201 | B | Induction of redissolving of aggregated alpha-crystallin A R116H mutant (unknown origin) at 200 uM incubated for 24 hrs by transmission-electron-microscopy | Homo sapiens | 2 | ALA4196177 | single protein format | Scientific Literature | |
| 12. | ALA4201202 | B | Induction of redissolving of aggregated alpha-crystallin A Y118D mutant (unknown origin) at 200 uM incubated for 24 hrs by transmission-electron-microscopy | Homo sapiens | 2 | ALA4196177 | single protein format | Scientific Literature | |
| 13. | ALA4201211 | B | Inhibition of alpha-crystallin A Y118D mutant (unknown origin)-induced cytotoxicity in human HeLa cells assessed as increase in cell viability at 0.04 to 4 uM incubated for 12 hrs by CCK8 assay | Homo sapiens | 5 | ALA4196177 | cell-based format | Scientific Literature | |
| 14. | ALA4201212 | B | Inhibition of alpha-crystallin A Y118D mutant (unknown origin)-induced cytotoxicity in human HLE-B3 cells assessed as increase in cell viability at 0.04 to 4 uM incubated for 12 hrs by CCK8 assay | Homo sapiens | 5 | ALA4196177 | cell-based format | Scientific Literature | |
| 15. | ALA5223306 | B | Inhibition of alphaA (66 to 80 residues) crystallin peptide aggregation at peptide to ligand ratio of 0.2 to 5:1 incubated for 7 days by fluorescence aggregation assay | 3 | ALA5223067 | single protein format | Scientific Literature | ||
| 16. | ALA5223307 | B | Inhibition of alphaA (66 to 80 residues) crystallin peptide aggregation incubated for 7 days by fluorescence aggregation assay | 3 | ALA5223067 | single protein format | Scientific Literature | ||
| 17. | ALA5223308 | B | Inhibition of alphaA (66 to 80 residues) crystallin peptide aggregation assessed as decrease in average diameter size distribution at 1:1 peptide to ligand ratio incubated for 7 days by fluorescence aggregation assay (Rvb=12000+/-1500 nm) | 3 | ALA5223067 | single protein format | Scientific Literature | ||
| 18. | ALA5223309 | B | Inhibition of alphaA (66 to 80 residues) crystallin peptide aggregation assessed decrease in large fibrillar aggregation at 1:1 peptide to ligand ratio incubated for 7 days by transmission electron microscopy | 3 | ALA5223067 | single protein format | Scientific Literature | ||
| 19. | ALA5223310 | B | Inhibition of alphaA (66 to 80 residues) crystallin peptide aggregation assessed as amorphous small protein aggregates at 1:1 peptide to ligand ratio incubated for 7 days by transmission electron microscopy | 3 | ALA5223067 | single protein format | Scientific Literature | ||
| 20. | ALA5223311 | B | Inhibition of alphaA (66 to 80 residues) crystallin peptide aggregation assessed as decrease in peptide-receptor complex and measured upto 2 hrs by ESI-MS analysis | 3 | ALA5223067 | single protein format | Scientific Literature |
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