# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4201167 | B | Inhibition of beta-crystallin B2 V187E mutant (unknown origin)-induced intracellular protein aggregation expressed in human HeLa cells or HLE-B3 cells at 4 uM incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control | Homo sapiens | 1 | ALA4196177 | cell-based format | Scientific Literature | |
2. | ALA4201171 | B | Inhibition of beta-crystallin B2 V187E mutant (unknown origin)-induced intracellular protein aggregation expressed in human HLE-B3 cells at 4 uM incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control | Homo sapiens | 6 | ALA4196177 | cell-based format | Scientific Literature | |
3. | ALA4201176 | B | Inhibition of beta-crystallin B2 V187E mutant (unknown origin)-induced intracellular protein aggregation expressed in human HeLa cells at 4 uM incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control | Homo sapiens | 6 | ALA4196177 | cell-based format | Scientific Literature | |
4. | ALA4201177 | B | Inhibition of beta-crystallin B2 V187E mutant (unknown origin)-induced intracellular protein aggregation expressed in human HeLa cells at 0.4 uM incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control | Homo sapiens | 6 | ALA4196177 | cell-based format | Scientific Literature | |
5. | ALA4201178 | B | Inhibition of beta-crystallin B2 V187E mutant (unknown origin)-induced intracellular protein aggregation expressed in human HLE-B3 cells at 0.4 uM incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control | Homo sapiens | 6 | ALA4196177 | cell-based format | Scientific Literature | |
6. | ALA4201197 | B | Induction of redissolving of aggregated beta-crystallin B2 R188H mutant (unknown origin) at 200 uM incubated for 24 hrs by ThT-fluorescence based assay | Homo sapiens | 2 | ALA4196177 | single protein format | Scientific Literature | |
7. | ALA4201206 | B | Induction of redissolving of aggregated beta-crystallin B2 R188H mutant (unknown origin) at 200 uM incubated for 24 hrs by transmission-electron-microscopy | Homo sapiens | 2 | ALA4196177 | single protein format | Scientific Literature | |
8. | ALA4201215 | B | Inhibition of beta-crystallin B2 V187E mutant (unknown origin)-induced cytotoxicity in human HeLa cells assessed as increase in cell viability at 0.04 to 4 uM incubated for 12 hrs by CCK8 assay | Homo sapiens | 6 | ALA4196177 | cell-based format | Scientific Literature | |
9. | ALA4201216 | B | Inhibition of beta-crystallin B2 V187E mutant (unknown origin)-induced cytotoxicity in human HLE-B3 cells assessed as increase in cell viability at 0.04 to 4 uM incubated for 12 hrs by CCK8 assay | Homo sapiens | 6 | ALA4196177 | cell-based format | Scientific Literature |