| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3742780 | Functional | Neuroprotective activity against Fenton reagent-induced ROS generation in human ARPE19 cells assessed as increase in GSH level at 1 mM after 2 hrs by DTNB method | Homo sapiens | 19 | ALA3739318 | cell-based format | Scientific Literature | |
| 2. | ALA4352148 | ADME | Cytotoxicity against human ARPE19 cells measured after 96 hrs by MTT assay | Homo sapiens | 26 | ALA4350962 | cell-based format | Scientific Literature | |
| 3. | ALA4363587 | ADME | Cytotoxicity against human ARPE19 cells at 30 to 300 uM measured after 48 hrs under normoxia condition in presence of CoCl2 by MTT assay relative to control | Homo sapiens | 3 | ALA4359910 | cell-based format | Scientific Literature | |
| 4. | ALA4363589 | ADME | Cytotoxicity against human ARPE19 cells at 300 uM measured after 48 hrs under normoxia condition in presence of CoCl2 by MTT assay | Homo sapiens | 1 | ALA4359910 | cell-based format | Scientific Literature | |
| 5. | ALA4363590 | ADME | Cytotoxicity against human ARPE19 cells at 30 to 300 uM measured after 48 hrs under normoxia condition in presence of CoCl2 by MTT assay | Homo sapiens | 3 | ALA4359910 | cell-based format | Scientific Literature | |
| 6. | ALA2343867 | Functional | Inhibition of intracellular A2E photooxidation in human ARPE19 cells at 20 uM after 18 days | Homo sapiens | 5 | ALA2331545 | cell-based format | Scientific Literature | |
| 7. | ALA4058198 | Functional | Cytoprotective activity against H2O2-induced toxicity in human ARPE19 cells up to 100 uM pretreated for 5 hrs followed by H2O2 addition after 19 hrs by CellTiter-blue assay | Homo sapiens | 1 | ALA4052786 | cell-based format | Scientific Literature | |
| 8. | ALA4058199 | Functional | Cytoprotective activity against H2O2-induced toxicity in human ARPE19 cells pretreated for 5 hrs followed by H2O2 addition after 19 hrs by CellTiter-blue assay | Homo sapiens | 4 | ALA4052786 | cell-based format | Scientific Literature | |
| 9. | ALA4058200 | ADME | Cytotoxicity against human ARPE19 cells assessed as reduction in cell viability up to 100 uM after 72 hrs by CellTiter-blue assay | Homo sapiens | 4 | ALA4052786 | cell-based format | Scientific Literature | |
| 10. | ALA4058228 | ADME | Cytotoxicity against human ARPE19 cells assessed as reduction in cell viability at 100 uM after 72 hrs by CellTiter-blue assay relative to control | Homo sapiens | 1 | ALA4052786 | cell-based format | Scientific Literature | |
| 11. | ALA4182652 | Functional | Suppression of 4-HNE-induced apoptosis in human ARPE19 cells assessed as viable cells level at 5 uM incubated for 24 hrs by FITC Annexin V and propidium iodide staining based flow cytometry (Rvb = 59.1%) | Homo sapiens | 2 | ALA4177728 | cell-based format | Scientific Literature | |
| 12. | ALA4182653 | Functional | Suppression of 4-HNE-induced apoptosis in human ARPE19 cells assessed as early apoptosis cells level at 5 uM incubated for 24 hrs by FITC Annexin V and propidium iodide staining based flow cytometry (Rvb = 17.6%) | Homo sapiens | 2 | ALA4177728 | cell-based format | Scientific Literature | |
| 13. | ALA4182654 | Functional | Suppression of 4-HNE-induced apoptosis in human ARPE19 cells assessed as late apoptosis cells level at 5 uM incubated for 24 hrs by FITC Annexin V and propidium iodide staining based flow cytometry (Rvb = 23%) | Homo sapiens | 2 | ALA4177728 | cell-based format | Scientific Literature | |
| 14. | ALA4182655 | Functional | Suppression of 4-HNE-induced apoptosis in human ARPE19 cells assessed as necrosis cells level at 5 uM incubated for 24 hrs by FITC Annexin V and propidium iodide staining based flow cytometry (Rvb = 0.342%) | Homo sapiens | 2 | ALA4177728 | cell-based format | Scientific Literature | |
| 15. | ALA4182656 | Functional | Suppression of 4-HNE-induced apoptosis in human ARPE19 cells assessed as viable cells level at 10 uM incubated for 24 hrs by FITC Annexin V and propidium iodide staining based flow cytometry (Rvb = 59.1%) | Homo sapiens | 2 | ALA4177728 | cell-based format | Scientific Literature | |
| 16. | ALA4182657 | Functional | Suppression of 4-HNE-induced apoptosis in human ARPE19 cells assessed as early apoptosis cells level at 10 uM incubated for 24 hrs by FITC Annexin V and propidium iodide staining based flow cytometry (Rvb = 17.6%) | Homo sapiens | 2 | ALA4177728 | cell-based format | Scientific Literature | |
| 17. | ALA4182658 | Functional | Suppression of 4-HNE-induced apoptosis in human ARPE19 cells assessed as late apoptosis cells level at 10 uM incubated for 24 hrs by FITC Annexin V and propidium iodide staining based flow cytometry (Rvb = 23%) | Homo sapiens | 2 | ALA4177728 | cell-based format | Scientific Literature | |
| 18. | ALA4182659 | Functional | Suppression of 4-HNE-induced apoptosis in human ARPE19 cells assessed as necrosis cells level at 10 uM incubated for 24 hrs by FITC Annexin V and propidium iodide staining based flow cytometry (Rvb = 0.342%) | Homo sapiens | 2 | ALA4177728 | cell-based format | Scientific Literature | |
| 19. | ALA4182660 | Functional | Suppression of 4-HNE-induced apoptosis in human ARPE19 cells assessed as viable cells level at 20 uM incubated for 24 hrs by FITC Annexin V and propidium iodide staining based flow cytometry (Rvb = 59.1%) | Homo sapiens | 2 | ALA4177728 | cell-based format | Scientific Literature | |
| 20. | ALA4182661 | Functional | Suppression of 4-HNE-induced apoptosis in human ARPE19 cells assessed as early apoptosis cells level at 20 uM incubated for 24 hrs by FITC Annexin V and propidium iodide staining based flow cytometry (Rvb = 17.6%) | Homo sapiens | 2 | ALA4177728 | cell-based format | Scientific Literature |
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