# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA898406 | F | Mitotic arrest in Pgp overexpressing KBV1 cells | Homo sapiens | 2 | ALA1137440 | cell-based format | Scientific Literature | |
2. | ALA922880 | F | Effect on Pgp expression level in human KB V1 cells at 4 uM after 72 hrs by Western blot | Homo sapiens | 1 | ALA1143069 | cell-based format | Scientific Literature | |
3. | ALA922881 | F | Effect on Pgp expression level in human KB V1 cells at 20 uM after 72 hrs by Western blot | Homo sapiens | 1 | ALA1143069 | cell-based format | Scientific Literature | |
4. | ALA2044669 | F | Multidrug resistant ratio of GI50 for human KBV1 cells expressing p-glycoprotein to GI50 for wild type human KB-3-1 cells | Homo sapiens | 5 | ALA2040733 | cell-based format | Scientific Literature | |
5. | ALA3858202 | F | Induction of lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp at 10 uM after 30 mins by acridine orange staining based fluorescence microscopic analysis | Homo sapiens | 6 | ALA3856230 | cell-based format | Scientific Literature | |
6. | ALA3858203 | F | Induction of ROS accumulation in human KBV1 cells over expressing P-gp at 10 uM after 30 mins by DCF-DA staining based flow cytometry | Homo sapiens | 6 | ALA3856230 | cell-based format | Scientific Literature | |
7. | ALA3858204 | F | Induction of ROS accumulation in human KBV1 cells over expressing P-gp at 50 uM after 30 mins by DCF-DA staining based flow cytometry relative to control | Homo sapiens | 1 | ALA3856230 | cell-based format | Scientific Literature | |
8. | ALA3858213 | F | Induction of copper-dependent lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as decrease in cathepsin D and LAMP2 lysosomal colocalization at 10 uM after 24 hrs by TexasRed staining based immunofluorescence microscopic analysis | Homo sapiens | 2 | ALA3856230 | cell-based format | Scientific Literature | |
9. | ALA3858214 | F | Induction of copper-dependent lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as decrease in cathepsin D and LAMP2 lysosomal colocalization at 25 uM after 24 hrs by TexasRed staining based immunofluorescence microscopic analysis | Homo sapiens | 2 | ALA3856230 | cell-based format | Scientific Literature | |
10. | ALA3858215 | F | Induction of copper-dependent lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as decrease in cathepsin D and LAMP2 lysosomal colocalization at 10 uM after 24 hrs in presence of Cu chelator tetrathiomolybdate by TexasRed staining based immunofluorescence microscopic analysis | Homo sapiens | 2 | ALA3856230 | cell-based format | Scientific Literature | |
11. | ALA3858216 | F | Induction of copper-dependent lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as decrease in cathepsin D and LAMP2 lysosomal colocalization at 25 uM after 24 hrs in presence of Cu chelator tetrathiomolybdate by TexasRed staining based immunofluorescence microscopic analysis | Homo sapiens | 2 | ALA3856230 | cell-based format | Scientific Literature | |
12. | ALA3858217 | F | Induction of oxidative stress-dependent lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as decrease in cathepsin D and LAMP2 lysosomal colocalization at 10 uM after 24 hrs by TexasRed staining based immunofluorescence microscopic analysis | Homo sapiens | 2 | ALA3856230 | cell-based format | Scientific Literature | |
13. | ALA3858218 | F | Induction of oxidative stress-dependent lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as decrease in cathepsin D and LAMP2 lysosomal colocalization at 25 uM after 24 hrs by TexasRed staining based immunofluorescence microscopic analysis | Homo sapiens | 2 | ALA3856230 | cell-based format | Scientific Literature | |
14. | ALA3858219 | F | Induction of oxidative stress-dependent lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as decrease in cathepsin D and LAMP2 lysosomal colocalization at 10 uM after 24 hrs in presence of antioxidant N-acetyl-L-cysteine by TexasRed staining based immunofluorescence microscopic analysis | Homo sapiens | 2 | ALA3856230 | cell-based format | Scientific Literature | |
15. | ALA3858220 | F | Induction of oxidative stress-dependent lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as decrease in cathepsin D and LAMP2 lysosomal colocalization at 25 uM after 24 hrs in presence of antioxidant N-acetyl-L-cysteine by TexasRed staining based immunofluorescence microscopic analysis | Homo sapiens | 2 | ALA3856230 | cell-based format | Scientific Literature | |
16. | ALA3867896 | F | Induction of apoptosis in human KBV1 cells assessed as viable cells at 1 uM after 48 hrs by Annexin V-FITC/propidium iodide staining based FACS analysis (Rvb = 86.1%) | Homo sapiens | 2 | ALA3867440 | cell-based format | Scientific Literature | |
17. | ALA3867897 | F | Induction of apoptosis in human KBV1 cells assessed as early apoptotic cells at 1 uM after 48 hrs by Annexin V-FITC/propidium iodide staining based FACS analysis (Rvb = 5.3%) | Homo sapiens | 2 | ALA3867440 | cell-based format | Scientific Literature | |
18. | ALA3867898 | F | Induction of apoptosis in human KBV1 cells assessed as late apoptotic cells at 1 uM after 48 hrs by Annexin V-FITC/propidium iodide staining based FACS analysis (Rvb = 7.6%) | Homo sapiens | 2 | ALA3867440 | cell-based format | Scientific Literature | |
19. | ALA3867899 | F | Induction of apoptosis in human KBV1 cells assessed as necrotic cells at 1 uM after 48 hrs by Annexin V-FITC/propidium iodide staining based FACS analysis (Rvb = 1%) | Homo sapiens | 2 | ALA3867440 | cell-based format | Scientific Literature | |
20. | ALA4003066 | F | Antiproliferative activity against vinblastine-resistant human KBV1 cells after 72 hrs by MTT assay | Homo sapiens | 7 | ALA4002569 | cell-based format | Scientific Literature |