# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4042002 | Functional | Cytotoxicity against human KCL22 cells assessed as cell viability at 1 uM after 48 hrs by MTS assay relative to control | Homo sapiens | 24 | ALA4041496 | cell-based format | Scientific Literature | |
2. | ALA4042003 | Functional | Cytotoxicity against human KCL22 cells harboring ABL1 T315I mutant assessed as cell viability at 1 uM after 48 hrs by MTS assay relative to control | Homo sapiens | 24 | ALA4041496 | cell-based format | Scientific Literature | |
3. | ALA4042004 | Functional | Cytotoxicity against human KCL22 cells assessed as reduction in cell viability at 1 uM after 48 hrs by MTS assay | Homo sapiens | 62 | ALA4041496 | cell-based format | Scientific Literature | |
4. | ALA4042005 | Functional | Cytotoxicity against human KCL22 cells harboring ABL1 T315I mutant assessed as reduction in cell viability at 1 uM after 48 hrs by MTS assay | Homo sapiens | 62 | ALA4041496 | cell-based format | Scientific Literature | |
5. | ALA4042006 | Functional | Cytotoxicity against human KCL22 cells assessed as reduction in cell viability after 48 hrs by MTS assay | Homo sapiens | 15 | ALA4041496 | cell-based format | Scientific Literature | |
6. | ALA4042007 | Functional | Cytotoxicity against human KCL22 cells harboring ABL1 T315I mutant assessed as reduction in cell viability after 48 hrs by MTS assay | Homo sapiens | 15 | ALA4041496 | cell-based format | Scientific Literature | |
7. | ALA4135580 | Functional | Growth inhibition of human KCL22 cells up to 1000 nM after 48 hrs by WST-8 assay | Homo sapiens | 1 | ALA4130523 | cell-based format | Scientific Literature | |
8. | ALA4158936 | Functional | Cytotoxicity against human KCL22 cells after 72 hrs by CellTiter-Glo luminescent cell viability assay | Homo sapiens | 2 | ALA4152390 | cell-based format | Scientific Literature | |
9. | ALA4158938 | Functional | Cytotoxicity against imatinib-resistant human KCL22 cells after 72 hrs by CellTiter-Glo luminescent cell viability assay | Homo sapiens | 2 | ALA4152390 | cell-based format | Scientific Literature | |
10. | ALA4200768 | Functional | Antitumor activity against human KCL22 cells xenografted in po dosed nude mouse assessed as tumor growth inhibition administered via gavage after 7 days post implantation measured twice weekly | Homo sapiens | 1 | ALA4196169 | organism-based format | Scientific Literature | |
11. | ALA4200769 | Functional | Antitumor activity against human KCL22 cells xenografted in nude mouse assessed as tumor growth level at 30 mg/kg, po bid administered via gavage for 7 days post implantation measured twice weekly relative to control | Homo sapiens | 1 | ALA4196169 | organism-based format | Scientific Literature | |
12. | ALA4200770 | Functional | Antitumor activity against human KCL22 cells xenografted in nude mouse assessed as tumor growth level at 3 mg/kg, po bid administered via gavage for 7 days post implantation measured twice weekly relative to control | Homo sapiens | 4 | ALA4196169 | organism-based format | Scientific Literature | |
13. | ALA4200845 | Functional | Antitumor activity against human KCL22 cells xenografted in po dosed nude mouse assessed as tumor growth inhibition administered as solid dispersion after 7 days post implantation measured twice weekly | Homo sapiens | 1 | ALA4196169 | organism-based format | Scientific Literature | |
14. | ALA4200846 | Functional | Antitumor activity against human KCL22 cells xenografted in nude mouse assessed as tumor regression at >=7.5 mg/kg, po bid administered as solid dispersion after 7 days post implantation measured twice weekly | Homo sapiens | 1 | ALA4196169 | organism-based format | Scientific Literature | |
15. | ALA4266343 | Functional | Induction of apoptosis in human KCL22 cells by Annexin V staining based assay | Homo sapiens | 1 | ALA4265875 | cell-based format | Scientific Literature | |
16. | ALA4387603 | Functional | Inhibition of cell expansion in human KCL22 cells at 0.3 to 3 uM incubated for 48 hrs by trypan blue dye exclusion counting method | Homo sapiens | 1 | ALA4385661 | cell-based format | Scientific Literature | |
17. | ALA4387604 | Functional | Inhibition of cell expansion in human KCL22 cells at 3 uM incubated for 48 hrs in presence of 10 nM nilotinib by trypan blue dye exclusion counting method | Homo sapiens | 1 | ALA4385661 | cell-based format | Scientific Literature | |
18. | ALA4387605 | Functional | Inhibition of cell expansion in human KCL22 cells at 10 nM incubated for 48 hrs by trypan blue dye exclusion counting method | Homo sapiens | 1 | ALA4385661 | cell-based format | Scientific Literature | |
19. | ALA4387606 | Functional | Induction of cell cycle arrest in human KCL22 cells assessed as accumulation at G0-G1 phase at 3 uM incubated for 72 hrs by propidium iodide staining based flow cytometry analysis (Rvb = 57.4%) | Homo sapiens | 1 | ALA4385661 | cell-based format | Scientific Literature | |
20. | ALA4387607 | Functional | Induction of cell cycle arrest in human KCL22 cells assessed as accumulation at subG0 phase at 3 uM incubated for 72 hrs by propidium iodide staining based flow cytometry analysis (Rvb = 3.91%) | Homo sapiens | 1 | ALA4385661 | cell-based format | Scientific Literature |