# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA989874 | F | Enhancement of calcein-AM uptake in MDCK2 cells over expressing MDR1 after 20 mins | Canis lupus familiaris | 10 | ALA1142530 | cell-based format | Scientific Literature | |
2. | ALA989881 | F | Efflux ratio of permeability from basolateral to apical side to apical to basolateral side in MDCK2 cells over expressing MDR1 to permeability from basolateral to apical side to apical to basolateral side in MDCK2 cells over expressing MDR1 in presence of 25 uM LSN335984 | Canis lupus familiaris | 9 | ALA1142530 | cell-based format | Scientific Literature | |
3. | ALA983531 | F | Inhibition of [3H]vinblastine transport in MDCK2 cells over expressing MDR1 assessed as [3H]vinblastine accumulation after 2.5 mins | Canis lupus familiaris | 1 | ALA1142530 | cell-based format | Scientific Literature | |
4. | ALA1694086 | F | Ratio of GI50 for dog MDCK2-MDR1 cells overexpressing human P-glycoprotein to GI50 for dog MDCK2 cells | Canis lupus familiaris | 18 | ALA1687930 | cell-based format | Scientific Literature | |
5. | ALA1936272 | F | Potentiation of SN-38 anticancer activity against MDCK2 cells expressing human BCRP after 72 hrs by MTT assay | Canis lupus familiaris | 1 | ALA1933063 | cell-based format | Scientific Literature | |
6. | ALA3095242 | F | Increase of plasma membrane expression of BCRP expressing reporter gene GFP in BCRP-MDCK2 cells at 0.5 to 1.8 uM after 72 hrs by fluorescence assay | Canis lupus familiaris | 5 | ALA3091323 | cell-based format | Scientific Literature | |
7. | ALA3811910 | F | Potentiation of SN-38-induced cytotoxicity in MDCK2 cells assessed as decrease in cell viability at 0.01 to 0.1 uM after 72 hrs by MTT assay | Canis lupus familiaris | 2 | ALA3808298 | cell-based format | Scientific Literature | |
8. | ALA4015701 | A | Cytotoxicity against ABCG2 over-expressing MDCK2 cells assessed as cell growth inhibition after 72 hrs by MTT assay | Canis lupus familiaris | 22 | ALA4014315 | cell-based format | Scientific Literature | |
9. | ALA4015702 | A | Cytotoxicity against MDCK2 cells assessed as cell growth inhibition after 72 hrs by MTT assay | Canis lupus familiaris | 22 | ALA4014315 | cell-based format | Scientific Literature | |
10. | ALA4015721 | A | Cytotoxicity against ABCG2 over-expressing MDCK2 cells assessed as effect on cell proliferation at low concentration after 72 hrs in absence of DMSO and presence of 1% methanol by MTT assay | Canis lupus familiaris | 4 | ALA4014315 | cell-based format | Scientific Literature | |
11. | ALA4015722 | F | Potentiation of SN-38 induced cytotoxicity against MDCK2 cells at 0.01 to 5 uM after 72 hrs by MTT assay | Canis lupus familiaris | 3 | ALA4014315 | cell-based format | Scientific Literature | |
12. | ALA4031929 | A | Apparent permeability across low efflux MDCK2 cells at 6 uM after 90 mins by LC-MS/MS method | Canis lupus familiaris | 20 | ALA4028878 | cell-based format | Scientific Literature | |
13. | ALA4037233 | A | Apparent permeability from basolateral side to apical side in MDCK2 harboring human MDR1 cells in presence of Pgp inhibitor GF120918 at 10 to 20 uM after 60 mins by LC-MS/MS method | Canis lupus familiaris | 1 | ALA4033778 | cell-based format | Scientific Literature | |
14. | ALA4037234 | A | Apparent permeability from basolateral side to apical side in MDCK2 harboring human MDR1 cells in absence of Pgp inhibitor GF120918 at 10 to 20 uM after 60 mins by LC-MS/MS method | Canis lupus familiaris | 1 | ALA4033778 | cell-based format | Scientific Literature | |
15. | ALA4037981 | A | Efflux ratio of apparent permeability in MDCK2-LE cells expressing human MDR1 | Canis lupus familiaris | 1 | ALA4033794 | cell-based format | Scientific Literature | |
16. | ALA4037982 | A | Efflux ratio of apparent permeability in MDCK2-LE cells transfected with mouse BCRP | Canis lupus familiaris | 1 | ALA4033794 | cell-based format | Scientific Literature | |
17. | ALA4045168 | F | Antimigratory activity against MDCK2 cells assessed as inhibition of HGF-induced cell scattering at 1 uM pretreated for 18 hrs followed by HGF addition measured after 20 to 24 hrs by crystal violet staining-based assay relative to control | Canis lupus familiaris | 55 | ALA4043145 | cell-based format | Scientific Literature | |
18. | ALA4045248 | F | Antimigratory activity against MDCK2 cells assessed as inhibition of HGF-induced cell scattering pretreated for 18 hrs followed by HGF addition measured after 20 to 24 hrs by crystal violet staining-based assay | Canis lupus familiaris | 1 | ALA4043145 | cell-based format | Scientific Literature | |
19. | ALA4048740 | A | Cytotoxicity against MDCK2 cells expressing human BCRP assessed as decrease in cell viability after 72 hrs by MTT assay | Canis lupus familiaris | 12 | ALA4043291 | cell-based format | Scientific Literature | |
20. | ALA4048741 | A | Cytotoxicity against MDCK2 cells assessed as decrease in cell viability after 72 hrs by MTT assay | Canis lupus familiaris | 12 | ALA4043291 | cell-based format | Scientific Literature |