# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4380754 | ADME | Effect on AKT level in human H3255 cells up to 10 uM treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis | Homo sapiens | 2 | ALA4376874 | cell-based format | Scientific Literature | |
2. | ALA4380798 | Functional | Antiproliferative activity against human H3255 cells measured after 3 days by CCK8 assay | Homo sapiens | 6 | ALA4376874 | cell-based format | Scientific Literature | |
3. | ALA4050505 | Functional | Cell cycle arrest in human H3255 cells harboring EGFR L858R mutant assessed as accumulation at G0/G1 phase after 24 hrs by propidium iodide staining based flow cytometry | Homo sapiens | 1 | ALA4049404 | cell-based format | Scientific Literature | |
4. | ALA4050511 | Functional | Induction of apoptosis in human H3255 cells harboring EGFR L858R mutant assessed as PARP cleavage at 0.03 to 3 uM after 48 hrs by immunoblotting | Homo sapiens | 1 | ALA4049404 | cell-based format | Scientific Literature | |
5. | ALA4050551 | Functional | Induction of apoptosis in human H3255 cells harboring EGFR L858R mutant assessed as caspase-3 cleavage at 0.03 to 3 uM after 48 hrs by immunoblotting | Homo sapiens | 1 | ALA4049404 | cell-based format | Scientific Literature | |
6. | ALA4050555 | Functional | Induction of apoptosis in human H3255 cells harboring EGFR L858R mutant assessed as caspase-3 cleavage at 1 uM after 48 hrs by immunoblotting | Homo sapiens | 2 | ALA4049404 | cell-based format | Scientific Literature | |
7. | ALA4050559 | Functional | Induction of apoptosis in human H3255 cells harboring EGFR L858R mutant assessed as PARP cleavage at 1 uM after 48 hrs by immunoblotting | Homo sapiens | 2 | ALA4049404 | cell-based format | Scientific Literature | |
8. | ALA4145729 | Functional | Antiproliferative activity against human H3255 cells harboring EGFR L858R mutant after 72 hrs by CellTiter-Glo assay | Homo sapiens | 3 | ALA4145441 | cell-based format | Scientific Literature | |
9. | ALA4267287 | Functional | Antiproliferative activity against human H3255 cells after 72 hrs by MTT assay | Homo sapiens | 15 | ALA4265907 | cell-based format | Scientific Literature | |
10. | ALA4267294 | Functional | Induction of apoptosis in human H3255 cells assessed as necrotic cells at 250 nM after 48 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 7.06%) | Homo sapiens | 1 | ALA4265907 | cell-based format | Scientific Literature | |
11. | ALA4267295 | Functional | Induction of apoptosis in human H3255 cells assessed as late apoptotic cells at 250 nM after 48 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 1.77%) | Homo sapiens | 1 | ALA4265907 | cell-based format | Scientific Literature | |
12. | ALA4267297 | Functional | Induction of apoptosis in human H3255 cells assessed as early apoptotic cells at 250 nM after 48 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 3.22%) | Homo sapiens | 1 | ALA4265907 | cell-based format | Scientific Literature | |
13. | ALA4267299 | Functional | Induction of apoptosis in human H3255 cells assessed as viable cells at 250 nM after 48 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 87.9%) | Homo sapiens | 1 | ALA4265907 | cell-based format | Scientific Literature | |
14. | ALA4267309 | Functional | Induction of apoptosis in human H3255 cells assessed as viable cells at 500 nM after 48 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 87.9%) | Homo sapiens | 1 | ALA4265907 | cell-based format | Scientific Literature | |
15. | ALA4267310 | Functional | Induction of apoptosis in human H3255 cells assessed as early apoptotic cells at 500 nM after 48 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 3.22%) | Homo sapiens | 1 | ALA4265907 | cell-based format | Scientific Literature | |
16. | ALA4267311 | Functional | Induction of apoptosis in human H3255 cells assessed as late apoptotic cells at 500 nM after 48 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 1.77%) | Homo sapiens | 1 | ALA4265907 | cell-based format | Scientific Literature | |
17. | ALA4267312 | Functional | Induction of apoptosis in human H3255 cells assessed as necrotic cells at 500 nM after 48 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 7.06%) | Homo sapiens | 1 | ALA4265907 | cell-based format | Scientific Literature | |
18. | ALA4267313 | Functional | Induction of apoptosis in human H3255 cells assessed as viable cells at 1000 nM after 48 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 87.9%) | Homo sapiens | 2 | ALA4265907 | cell-based format | Scientific Literature | |
19. | ALA4267314 | Functional | Induction of apoptosis in human H3255 cells assessed as early apoptotic cells at 1000 nM after 48 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 3.22%) | Homo sapiens | 2 | ALA4265907 | cell-based format | Scientific Literature | |
20. | ALA4267315 | Functional | Induction of apoptosis in human H3255 cells assessed as late apoptotic cells at 1000 nM after 48 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 1.77%) | Homo sapiens | 2 | ALA4265907 | cell-based format | Scientific Literature |