| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4000443 | F | Antiproliferative activity against human OCI-AML3 cells after 72 hrs by MTT assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 2. | ALA4000454 | F | Antiproliferative activity against human OCI-AML3 cells after 72 hrs in presence of SAHA by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4009944 | F | Antiproliferative activity against human OCI-AML3 cells harboring NPM1c+, DNMT3A R882C mutant assessed as cell growth inhibition after 48 hrs by WST1 assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4024944 | F | Growth inhibition of human OCI-AML3 cells | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 5. | ALA4045014 | F | Antiproliferative activity against human OCI-AML3 cells after 72 hrs by MTT assay | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 6. | ALA4130963 | F | Antiproliferative activity against human OCI-AML3 cells after 72 hrs by CellTiter-Glo assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA4201012 | F | Growth inhibition of human OCI-AML3 cells harboring NRAS-Q61L mutant after 72 hrs by celltiter-glo assay | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 8. | ALA4201045 | F | Induction of apoptosis in human OCI-AML3 cells harboring NRAS Q61L mutant assessed as increase in cleaved PARP levels at 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA4201046 | F | Induction of apoptosis in human OCI-AML3 cells harboring NRAS Q61L mutant assessed as increase in cleaved caspase-3 levels at 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA4201047 | F | Induction of apoptosis in human OCI-AML3 cells harboring NRAS Q61L mutant assessed as decrease in bcl2 levels at 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4201048 | F | Induction of apoptosis in human OCI-AML3 cells harboring NRAS Q61L mutant assessed as decrease in mcl1 levels at 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA4201082 | F | Induction of apoptosis in human OCI-AML3 cells harboring NRAS Q61L mutant assessed as increase in apoptotic cells at 1 uM after 24 hrs by annexin V/propidium iodide staining based FACS analysis relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA4201084 | F | Induction of apoptosis in human OCI-AML3 cells harboring NRAS Q61L mutant assessed as increase in apoptotic cells after 24 hrs by annexin V/propidium iodide staining based FACS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4201085 | F | Cell cycle arrest in human OCI-AML3 cells harboring NRAS Q61L mutant assessed as accumulation at G0/G1 phase at 1 uM after 24 hrs by propidium iodide staining based FACS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA4201086 | F | Inhibition of anchorage-independent cell growth in human OCI-AML3 cells harboring NRAS Q61L mutant assessed as reduction in colony number at 0.1 to 1 uM after 14 days by iodonitrotetrazolium chloride staining-based soft agar assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 16. | ALA4201087 | F | Inhibition of anchorage-independent cell growth in human OCI-AML3 cells harboring NRAS Q61L mutant assessed as reduction in colony size at 0.1 to 1 uM after 14 days by iodonitrotetrazolium chloride staining-based soft agar assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 17. | ALA4201093 | F | Antileukemic activity against human OCI-AML3 cells harboring NRAS-Q61L mutant xenografted in immunodeficient mouse assessed as tumor volume at 8 mg/kg/day, po qd administered on day 21 post implantation measured on day 20 post implantation (Rvb = 100%) | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4201094 | F | Antileukemic activity against human OCI-AML3 cells harboring NRAS-Q61L mutant xenografted in immunodeficient mouse assessed as tumor volume at 15 mg/kg/day, po qd administered on day 21 post implantation measured on day 20 post dose (Rvb = 100%) | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4201095 | F | Antileukemic activity against human OCI-AML3 cells harboring NRAS-Q61L mutant xenografted in immunodeficient mouse assessed as tumor volume at 25 mg/kg/day, po qd administered on day 21 post implantation measured on day 20 post dose (Rvb = 100%) | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4201096 | F | Antileukemic activity against human OCI-AML3 cells harboring NRAS-Q61L mutant xenografted in immunodeficient po dosed mouse administered qd on day 21 post implantation measured on day 20 post dose | Homo sapiens | 1 | organism-based format | Scientific Literature |
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