# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4140666 | F | Cytoprotective activity against H2O2-induced oxidative stress in human TIG3 cells assessed as increase in full length PARP level at 0.3 uM pretreated with H2O2 for 2 hrs followed by compound addition by immunoblot analysis | Homo sapiens | 1 | ALA4138133 | cell-based format | Scientific Literature | |
2. | ALA4140667 | A | Cytotoxicity against human TIG3 cells assessed as cell death at 1 uM after 48 hrs relative to control | Homo sapiens | 1 | ALA4138133 | cell-based format | Scientific Literature | |
3. | ALA4140669 | A | Cytotoxicity against human TIG3 cells assessed as reduction in cell viability at 1 to 10 uM after 72 hrs | Homo sapiens | 1 | ALA4138133 | cell-based format | Scientific Literature | |
4. | ALA4140671 | A | Cytotoxicity against human TIG3 cells assessed as inhibition of colony formation at 0.1 to 0.3 uM by crystal violet staining based assay | Homo sapiens | 1 | ALA4138133 | cell-based format | Scientific Literature | |
5. | ALA4140673 | A | Cytotoxicity against human TIG3 cells assessed as cell death at 0.6 uM | Homo sapiens | 2 | ALA4138133 | cell-based format | Scientific Literature | |
6. | ALA4140674 | A | Cytotoxicity against human TIG3 cells assessed as inhibition of colony formation by crystal violet staining based assay | Homo sapiens | 1 | ALA4138133 | cell-based format | Scientific Literature | |
7. | ALA4140676 | A | Cytotoxicity against human TIG3 cells assessed as induction of morphological changes at 0.3 to 1.5 uM after 48 hrs by phase contrast microscopy | Homo sapiens | 2 | ALA4138133 | cell-based format | Scientific Literature | |
8. | ALA4140677 | A | Cytotoxicity against human TIG3 cells assessed as decrease in ROS generation at 1.5 to 3 uM after 48 hrs | Homo sapiens | 2 | ALA4138133 | cell-based format | Scientific Literature | |
9. | ALA4140678 | A | Cytotoxicity against human TIG3 cells assessed as induction of senescence at 64 population doubling at 0.1 uM | Homo sapiens | 1 | ALA4138133 | cell-based format | Scientific Literature | |
10. | ALA4140679 | A | Cytotoxicity against human TIG3 cells assessed as induction of senescence at 70 to 72 population doubling at 0.5 uM | Homo sapiens | 1 | ALA4138133 | cell-based format | Scientific Literature | |
11. | ALA4140680 | A | Induction of oxidative stress against human TIG3 cells assessed as increase in CARF mRNA levels by RT-PCR analysis | Homo sapiens | 2 | ALA4138133 | cell-based format | Scientific Literature | |
12. | ALA4140681 | A | Induction of oxidative stress in human TIG3 cells assessed as increase in GADD45alpha mRNA levels by RT-PCR analysis | Homo sapiens | 2 | ALA4138133 | cell-based format | Scientific Literature | |
13. | ALA4140682 | A | Effect on p53 expression level in human TIG3 cells at 0.3 to 3 uM by immunoblot analysis | Homo sapiens | 1 | ALA4138133 | cell-based format | Scientific Literature | |
14. | ALA4140683 | A | Effect on p21 WAF1 expression level in human TIG3 cells at 0.3 to 3 uM by immunoblot analysis | Homo sapiens | 1 | ALA4138133 | cell-based format | Scientific Literature | |
15. | ALA4140684 | A | Effect on mortalin expression level in human TIG3 cells at 0.3 to 3 uM by immuno fluorescence analysis | Homo sapiens | 2 | ALA4138133 | cell-based format | Scientific Literature | |
16. | ALA4140685 | A | Decrease in keap1 expression level in human TIG3 cells at 0.3 to 3 uM by immunoblot analysis | Homo sapiens | 2 | ALA4138133 | cell-based format | Scientific Literature | |
17. | ALA4140686 | A | Decrease in Nrf2 expression level in human TIG3 cells at 0.3 to 3 uM by immunoblot analysis | Homo sapiens | 2 | ALA4138133 | cell-based format | Scientific Literature | |
18. | ALA4140687 | A | Induction of oxidative stress in human TIG3 cells assessed as increase in CARF expression level at 0.6 uM by immunoblot analysis | Homo sapiens | 2 | ALA4138133 | cell-based format | Scientific Literature | |
19. | ALA4140688 | A | Induction of oxidative stress in human TIG3 cells assessed as increase in p53 expression level at 0.6 uM by immunoblot analysis | Homo sapiens | 2 | ALA4138133 | cell-based format | Scientific Literature | |
20. | ALA4140690 | A | Induction of apoptosis in human TIG3 cells assessed as decrease in Bcl2 levels at 0.3 to 3 uM by immunoblot analysis | Homo sapiens | 1 | ALA4138133 | cell-based format | Scientific Literature |