# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1033282 | F | Induction of p53 phosphorylation at Ser15 in human TK6 cells expressing wild type p53 at 0.1 uM after 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA1137756 | cell-based format | Scientific Literature | |
2. | ALA1033283 | F | Induction of p53 transcriptional activity in human TK6 cells expressing wild type p53 assessed as p21-Cip1/Waf1 expression at 0.1 uM after 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA1137756 | cell-based format | Scientific Literature | |
3. | ALA1033286 | F | Induction of p53 phosphorylation at Ser15 in human TK6 cells expressing wild type p53 at 25 uM after 8 hrs by Western blot analysis | Homo sapiens | 3 | ALA1137756 | cell-based format | Scientific Literature | |
4. | ALA1033287 | F | Induction of p53 transcriptional activity in human TK6 cells expressing wild type p53 assessed as p21-Cip1/Waf1 expression at 25 uM after 8 hrs by Western blot analysis | Homo sapiens | 3 | ALA1137756 | cell-based format | Scientific Literature | |
5. | ALA1033290 | F | Induction of apoptosis in human TK6 cells expressing wild type p53 assessed as live cell population at 25 uM after 8 hrs using annexin-V and 7-ADD staining by flow cytometry | Homo sapiens | 2 | ALA1137756 | cell-based format | Scientific Literature | |
6. | ALA1033492 | F | Induction of apoptosis in human TK6 cells expressing wild type p53 assessed as depolarization of inner mitochondrial membrane potential at 25 uM after 8 hrs by flow cytometry relative to CCCP | Homo sapiens | 2 | ALA1137756 | cell-based format | Scientific Literature | |
7. | ALA1033493 | F | Induction of apoptosis in human TK6 cells expressing wild type p53 assessed as increase in cleaved caspase 3 level at 25 uM after 8 hrs by Western blot analysis | Homo sapiens | 2 | ALA1137756 | cell-based format | Scientific Literature | |
8. | ALA1033496 | F | Induction of apoptosis in human TK6 cells expressing wild type p53 assessed as increase in cleaved caspase 3 level at 0.1 uM after 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA1137756 | cell-based format | Scientific Literature | |
9. | ALA1033499 | F | Induction of apoptosis in human TK6 cells expressing wild type p53 assessed as decrease in pro-caspase 3 level at 25 uM after 8 hrs by Western blot analysis | Homo sapiens | 2 | ALA1137756 | cell-based format | Scientific Literature | |
10. | ALA1033502 | F | Induction of apoptosis in human TK6 cells expressing wild type p53 assessed as decrease in pro-caspase 3 level at 0.1 uM after 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA1137756 | cell-based format | Scientific Literature | |
11. | ALA1034346 | F | Induction of apoptosis in human TK6 cells expressing wild type p53 assessed as increase in PARP cleavage at 25 uM after 8 hrs by Western blot analysis | Homo sapiens | 2 | ALA1137756 | cell-based format | Scientific Literature | |
12. | ALA1034349 | F | Induction of apoptosis in human TK6 cells expressing wild type p53 assessed as increase in PARP cleavage at 0.1 uM after 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA1137756 | cell-based format | Scientific Literature | |
13. | ALA1034354 | F | Induction of apoptosis in human TK6 cells expressing wild type p53 assessed as reduction of Bcl-Xl level at 25 uM after 8 hrs by Western blot analysis | Homo sapiens | 2 | ALA1137756 | cell-based format | Scientific Literature | |
14. | ALA1034357 | F | Induction of apoptosis in human TK6 cells expressing wild type p53 assessed as reduction of Bcl-2 level at 25 uM after 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA1137756 | cell-based format | Scientific Literature | |
15. | ALA1034360 | F | Induction of apoptosis in human TK6 cells expressing wild type p53 assessed as effect on Bcl-Xl mRNA level at 25 uM after 8 hrs by RT-PCR | Homo sapiens | 1 | ALA1137756 | cell-based format | Scientific Literature | |
16. | ALA1034361 | F | Induction of apoptosis in human TK6 cells expressing wild type p53 assessed as effect on Bcl-Xs mRNA level at 25 uM after 8 hrs by RT-PCR | Homo sapiens | 1 | ALA1137756 | cell-based format | Scientific Literature | |
17. | ALA1034364 | F | Induction of apoptosis in human TK6 cells expressing wild type p53 assessed as early stage apoptotic cell population at 25 uM after 8 hrs using annexin-V and 7-ADD staining by flow cytometry | Homo sapiens | 2 | ALA1137756 | cell-based format | Scientific Literature | |
18. | ALA1034365 | F | Induction of apoptosis in human TK6 cells expressing wild type p53 assessed as late stage apoptotic cell population at 25 uM after 8 hrs using annexin-V and 7-ADD staining by flow cytometry | Homo sapiens | 2 | ALA1137756 | cell-based format | Scientific Literature | |
19. | ALA1034366 | F | Induction of apoptosis in human TK6 cells expressing wild type p53 assessed as necrotic cell population at 25 uM after 8 hrs using annexin-V and 7-ADD staining by flow cytometry | Homo sapiens | 2 | ALA1137756 | cell-based format | Scientific Literature | |
20. | ALA1912589 | F | Induction of apoptosis in human TK6 cells assessed as viable cells at 50 ug/ml after 2 hrs by annexin V/propidium iodide staining method relative to control | Homo sapiens | 2 | ALA1909620 | cell-based format | Scientific Literature |