# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4119718 | F | Antiproliferative activity against Ptch+/- and p53-/- mouse medulloblastoma cells after 36 hrs by Brdu incorporation assay | Mus musculus | 4 | ALA4118081 | cell-based format | Scientific Literature | |
2. | ALA4119720 | F | Antitumor activity against Ptch+/- and p53-/- mouse medulloblastoma cells allografted in athymic nude mouse assessed as tumor growth inhibition at 50 mg/kg, po bid administered daily via gavage for 13 days | Mus musculus | 2 | ALA4118081 | organism-based format | Scientific Literature | |
3. | ALA4119721 | F | Antitumor activity against Ptch+/- and p53-/- mouse medulloblastoma cells allografted in athymic nude mouse assessed as tumor growth inhibition at 100 mg/kg, po qd administered daily via gavage for 13 days | Mus musculus | 1 | ALA4118081 | organism-based format | Scientific Literature | |
4. | ALA4122764 | F | Anti-tumor activity against mouse Ptch+/- p53-/- medulloblastoma cells implanted in athymic nude mouse assessed as tumor growth inhibition at 10 to 20 mg/kg, po administered twice daily via gavage measured every other day during compound dosing | Mus musculus | 1 | ALA4118161 | organism-based format | Scientific Literature | |
5. | ALA4122765 | F | Anti-tumor activity against mouse Ptch+/- p53-/- medulloblastoma cells implanted in athymic nude mouse assessed as tumor growth inhibition at 20 mg/kg, po administered twice daily via gavage measured every other day during compound dosing | Mus musculus | 1 | ALA4118161 | organism-based format | Scientific Literature | |
6. | ALA4273271 | F | Growth inhibition of mouse Ptch+/- medulloblastoma cells at 0.125 uM after 72 hrs relative to control | Mus musculus | 5 | ALA4270564 | cell-based format | Scientific Literature | |
7. | ALA4273272 | F | Growth inhibition of mouse Ptch+/- medulloblastoma cells at 0.25 uM after 72 hrs relative to control | Mus musculus | 5 | ALA4270564 | cell-based format | Scientific Literature | |
8. | ALA4273273 | F | Growth inhibition of mouse Ptch+/- medulloblastoma cells at 0.5 uM after 72 hrs relative to control | Mus musculus | 5 | ALA4270564 | cell-based format | Scientific Literature | |
9. | ALA4273274 | F | Growth inhibition of mouse Ptch+/- medulloblastoma cells at 1 uM after 72 hrs relative to control | Mus musculus | 5 | ALA4270564 | cell-based format | Scientific Literature | |
10. | ALA4273275 | F | Growth inhibition of mouse Ptch+/- medulloblastoma cells at 2 uM after 72 hrs relative to control | Mus musculus | 5 | ALA4270564 | cell-based format | Scientific Literature | |
11. | ALA4273276 | F | Synergistic growth inhibition of mouse Ptch+/- medulloblastoma cells at 0.125 uM after 72 hrs in presence of Gli inhibitor GlaB | Mus musculus | 2 | ALA4270564 | cell-based format | Scientific Literature | |
12. | ALA4273277 | F | Synergistic growth inhibition of mouse Ptch+/- medulloblastoma cells at 0.25 uM after 72 hrs in presence of Gli inhibitor GlaB | Mus musculus | 2 | ALA4270564 | cell-based format | Scientific Literature | |
13. | ALA4273278 | F | Synergistic growth inhibition of mouse Ptch+/- medulloblastoma cells at 0.5 uM after 72 hrs in presence of Gli inhibitor GlaB | Mus musculus | 2 | ALA4270564 | cell-based format | Scientific Literature | |
14. | ALA4384335 | F | Antiproliferative activity against medulloblastoma cells derived from conditional patched knockout mouse after 48 hrs by [3H]-thymidine incorporation assay | Mus musculus | 9 | ALA4382241 | cell-based format | Scientific Literature | |
15. | ALA4388218 | F | Antiproliferative activity against medulloblastoma cells derived from conditional patched knockout mouse after 48 hrs by [3H]-thymidine incorporation assay | Mus musculus | 7 | ALA4387707 | cell-based format | Scientific Literature | |
16. | ALA4394254 | F | Antiproliferative activity against mouse Ptch+/- medulloblastoma cells assessed as inhibition of cell growth incubated for 36 hrs by CCK-8 assay | Mus musculus | 2 | ALA4393662 | cell-based format | Scientific Literature |