Antiviral activity against Middle East respiratory syndrome-related coronavirus infected in African green monkey Vero81 cells assessed as reduction in viral titer after 48 hrs
Middle East respiratory syndrome-related coronavirus
Antiviral activity against MERS-CoV pseudovirus infected in human HuH7 cells treated with 30 mins pre-treated pseudovirus/compopund mixture and measured after 48 hrs by luciferase reporter assay
Middle East respiratory syndrome-related coronavirus
Antiviral activity against MERS-CoV pseudovirus infected in human HuH7 cells treated with 30 mins pre-treated pseudovirus/compopund mixture up to 40 uM and measured after 48 hrs by luciferase reporter assay
Middle East respiratory syndrome-related coronavirus
Antiviral activity against MERS-CoV KOR/KNIH/002_05_2015 infected in African green monkey Vero cells expressing viral spike protein by immunofluorescence assay
Middle East respiratory syndrome-related coronavirus
Antiviral activity against MERS-CoV infected in human Caco2 cells assessed as inhibition of viral replication measured at 18 hrs post-infection by plaque formation assay
Middle East respiratory syndrome-related coronavirus
Antiviral activity against MERS-CoV EMC/2012 infected in African green monkey Vero cells assessed as log reduction in virus titre at >0.3 uM measured after 48 hrs viral infection by plaque assay
Middle East respiratory syndrome-related coronavirus
Antiviral activity against Middle East respiratory syndrome coronavirus infected in HuH7 cells expressing T7 RNA polymerase assessed as reduction in virus-induced cytopathic effect incubated for 2 days by non-radioactive cell proliferation assay
Middle East respiratory syndrome-related coronavirus
Antiviral activity against Middle East respiratory syndrome coronavirus infected in Vero cells assessed as reduction in virus-induced cytopathic effect incubated for 3 days by non-radioactive cell proliferation assay
Middle East respiratory syndrome-related coronavirus
Antiviral activity against MERS-CoV EMC/2012 infected in African green monkey Vero cells pretreated with compound followed by viral infection and measured at 72 hrs post-infection by MTS assay
Middle East respiratory syndrome-related coronavirus
Antiviral activity against Middle East respiratory syndrome coronavirus MERS-CoV/KOR/KNIH/002_05_2015 infected in African green monkey Vero cells assessed as reduction in virus induced cytopathic effect after 24 hrs by immunofluorescence assay
Middle East respiratory syndrome-related coronavirus
Antiviral activity against MERS-CoV Hu/Jordan-N3/2012 infected in African green monkey Vero E6 cells assessed as inhibition of viral replication treated for 1 hr prior to viral infection and measured after 48 hrs by ELISA
Middle East respiratory syndrome-related coronavirus
Antiviral activity against MERS-CoV infected in African green monkey Vero cells assessed as inhibition of viral infection by measuring reduction in spike protein level by immunofluorescence microscopic analysis
Middle East respiratory syndrome-related coronavirus
Antiviral activity against pseudovirus MERS-CoV spike glycoprotein infected human Huh-7 cells assessed as inhibition of viral infection measured after 24 hrs by luciferase reporter gene assay
Middle East respiratory syndrome-related coronavirus
Antiviral activity against MERS-CoV assessed as inhibition of S protein mediated cell-cell fusion in Huh-7 cells measured after 2 hrs by inverted fluorescence microscopy
Middle East respiratory syndrome-related coronavirus
Antiviral activity against MERS-CoV assessed as reduction in viral infection preincubated with virus for 30 mins followed by Huh-7 cells addition and culture replaced with fresh medium after 12 hrs post infection measured after 48 hrs by fluorescence assay
Middle East respiratory syndrome-related coronavirus