| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA746119 | F | Percent inhibition was determined at a dose of 10 mg/Kg in mouse ex vivo assay | 11 | assay format | Scientific Literature | |||
| 2. | ALA843214 | F | Percent inhibition was determined at a dose of 10 mg/Kg in mouse ex vivo assay | 1 | assay format | Scientific Literature | |||
| 3. | ALA990977 | B | Inhibition of leukotriene A4 hydrolase activity in CD1 mouse whole blood assessed as A-23187-stimulated LTB4 production after 15 mins by enzyme immunoassay | Mus musculus | 28 | tissue-based format | Scientific Literature | ||
| 4. | ALA2320734 | B | Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calcium ionophore challenge measured after 10 to 30 mins by enzyme immunoassay | Mus musculus | 27 | single protein format | Scientific Literature | ||
| 5. | ALA4009233 | B | Inhibition of LTA4H epoxide hydrolase in C57BL/6 mouse neutrophils assessed as suppression of fMLP-induced neutrophil migration pretreated for 30 mins followed by stimulation with fMLP for 1 hr by chemotaxis assay | Mus musculus | 3 | single protein format | Scientific Literature | ||
| 6. | ALA4009234 | B | Inhibition of LTA4H epoxide hydrolase in C57BL/6 mouse neutrophils assessed as suppression of fMLP-induced neutrophil migration co-treated with ((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido)-4-methylpentanoic acid for 30 mins followed by stimulation with fMLP for 1 hr by chemotaxis assay | Mus musculus | 1 | single protein format | Scientific Literature | ||
| 7. | ALA4009298 | B | Inhibition of LTA4H in C57BL/6 mouse assessed as reduction in LTB4 production pre-incubated for 30 mins before 5-(methylamino)-2-({(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxylic acid stimulation for 30 mins by ELISA | Mus musculus | 3 | single protein format | Scientific Literature | ||
| 8. | ALA4834669 | F | Ex-vivo inhibition of LTA4H in blood isolated from C57/BL6 mouse assessed as reduction of calcium ionophore A23187-stimulated LTB4 generation at 10 mg/kg, po measured after 14 hrs by EIA assay | Mus musculus | 15 | organism-based format | Scientific Literature | ||
| 9. | ALA4834729 | F | Ex-vivo inhibition of LTA4H in blood isolated from C57/BL6 mouse assessed as reduction of calcium ionophore A23187-stimulated LTB4 generation at 0.625 mg/kg, po BID for 3 days measured after 2 hrs post last dose by EIA assay relative to control | Mus musculus | 1 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!