| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4379111 | F | Ex vivo neuroprotective activity against high glucose-induced neuronal cell death in retina isolated from C57BL/6 mouse model of diabetic retinopathy assessed as decrease in Chx10+/active caspase 3+ dying bipolar cells level at 1 uM measured after 5 days by immunohistochemistry analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 2. | ALA4379112 | F | Ex vivo neuroprotective activity against high glucose-induced neuronal cell death in retina isolated from C57BL/6 mouse model of diabetic retinopathy assessed as decrease in TUNEL positive cells at 1 uM measured after 5 days by TUNEL assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4379113 | F | Ex vivo neuroprotective activity against high glucose-induced oxidative stress in retina isolated from C57BL/6 mouse model of diabetic retinopathy assessed as decrease in ROS level at 1 uM measured after 5 days by DCF/DHE probe based fluorescence assay | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 4. | ALA4379114 | F | Ex vivo neuroprotective activity against high glucose-induced gliosis in retina isolated from C57BL/6 mouse model of diabetic retinopathy assessed as inhibition of Muller glia cells proliferation labelled with GS+/PH3+ at 1 uM measured after 5 days by immunohistochemistry | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 5. | ALA4379115 | F | Ex vivo neuroprotective activity against high glucose-induced microvascular changes in retina isolated from C57BL/6 mouse model of diabetic retinopathy assessed as suppression of vascular vessel regression at 1 uM measured after 5 days by IB4 staining based immunohistochemistry | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 6. | ALA4379505 | F | Ex vivo neuroprotective activity against high glucose-induced microvascular changes in retina isolated from C57BL/6 mouse model of diabetic retinopathy assessed as suppression of vascular vessel regression by measuring decrease in total vessel length at 1 uM measured after 5 days by IB4 staining based immunohistochemistry | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 7. | ALA4379506 | F | Ex vivo neuroprotective activity against high glucose-induced microvascular changes in retina isolated from C57BL/6 mouse model of diabetic retinopathy assessed as suppression of vascular vessel regression by measuring increase in lacu-narity at 1 uM measured after 5 days by IB4 staining based immunohistochemistry | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 8. | ALA4379507 | F | Ex vivo neuroprotective activity against high glucose-induced microvascular changes in retina isolated from C57BL/6 mouse model of diabetic retinopathy assessed as suppression of vascular vessel regression by measuring decrease in vessel covered area at 1 uM measured after 5 days by IB4 staining based immunohistochemistry | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 9. | ALA4731680 | A | Effect on C57BL/6 mouse retina with CD73-/- deficient incubated for 1 hr by microscopic analysis | Mus musculus | 2 | tissue-based format | Scientific Literature |
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