Photo-activated cytotoxicity against mouse B16-F10-luc2 cells assessed as cell viability at 1 uM preincubated for 3 hrs followed by compound washout and subsequent 22.8 J cm'-2 light irradiation for 60 secs measured after 21 hrs by MTT assay relative to control
Cytotoxicity against mouse B16-F10-luc2 cells assessed as cell viability at 1 uM incubated for 24 hrs under dark condition by MTT assay relative to control
Photo-activated cytotoxicity against mouse B16-F10-luc2 cells assessed as reduction in cell viability preincubated for 3 hrs followed by compound washout and subsequent 22.8 J cm'-2 light irradiation for 60 secs measured after 21 hrs by MTT assay
Induction of apoptosis in mouse B16-F10-luc2 cells assessed as decrease in viable cells at 1 uM preincubated for 3 hrs followed by compound washout and subsequent 22.8 J cm'-2 light irradiation for 60 secs measured after 21 hrs by Alexa Fluor 488 Annexin V/Dead Cell staining based flow cytometry
Induction of apoptosis in mouse B16-F10-luc2 cells assessed as increase in late apoptotic cells at 1 uM preincubated for 3 hrs followed by compound washout and subsequent 22.8 J cm'-2 light irradiation for 60 secs measured after 21 hrs by Alexa Fluor 488 Annexin V/Dead Cell staining based flow cytometry
Induction of apoptosis in mouse B16-F10-luc2 cells assessed as increase in necrotic cells at 1 uM preincubated for 3 hrs followed by compound washout and subsequent 22.8 J cm'-2 light irradiation for 60 secs measured after 21 hrs by Alexa Fluor 488 Annexin V/Dead Cell staining based flow cytometry
Induction of apoptosis in mouse B16-F10-luc2 cells assessed as decrease in viable cells at 1 uM measured after 24 hrs by Alexa Fluor 488 Annexin V/Dead Cell staining based flow cytometry
Induction of apoptosis in mouse B16-F10-luc2 cells assessed as increase in late apoptotic cells at 1 uM measured after 24 hrs by Alexa Fluor 488 Annexin V/Dead Cell staining based flow cytometry
Induction of apoptosis in mouse B16-F10-luc2 cells assessed as increase in necrotic cells at 1 uM measured after 24 hrs by Alexa Fluor 488 Annexin V/Dead Cell staining based flow cytometry
Induction of reactive oxygen species generation in mouse B16-F10-luc2 cells at 10 uM preincubated for 3 hrs followed by compound washout prior to DHFA addition for 1 hr and subsequent 22.8 J cm'-2 light irradiation for 60 secs post media washout and measured immediately by fluorescence assay
Antitumor activity against mouse B16-F10-luc2 cells implanted in SCID mouse assessed as tumor growth at 100 uM, iv administered on day 1, 2, 7, and 9 measured for 12 days relative to control
Antitumor activity against mouse B16-F10-luc2 cells implanted in SCID mouse assessed as tumor volume at 100 uM, iv administered 30 mins prior to 68.4 J cm'-2 light irradiation for 3 mins on day 1, 2, 7, and 9 measured for 12 days relative to control
Antitumor activity against mouse B16-F10-luc2 cells implanted in SCID mouse assessed as tumor growth at 100 uM, iv administered 30 mins prior to 68.4 J cm'-2 light irradiation for 3 mins on day 1, 2, 7, and 9 measured for 12 days relative to control
Antitumor activity against mouse B16-F10-luc2 cells implanted in SCID mouse assessed as reduction in tumor growth at 100 uM, iv administered 30 mins prior to 68.4 J cm'-2 light irradiation for 3 mins on day 1, 2, 7, and 9 measured on day 13