# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3811281 | F | Induction of apoptosis in human GISTT1 cells assessed as caspase 3 cleavage up to 3 uM after 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA3808357 | cell-based format | Scientific Literature | |
2. | ALA3811282 | F | Induction of apoptosis in human GISTT1 cells assessed as PARP cleavage up to 3 uM after 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA3808357 | cell-based format | Scientific Literature | |
3. | ALA3811485 | F | Induction of apoptosis in human GISTT1 cells xenografted in nu/nu mouse at 25 to 100 mg/kg/day administered through oral gavage after 21 days by tunel assay | Homo sapiens | 1 | ALA3808357 | organism-based format | Scientific Literature | |
4. | ALA3879101 | F | Induction of apoptosis in human GISTT1 cells assessed as increase in cleaved caspase-3 level at 0.1 to 3 uM by Western blot analysis | Homo sapiens | 1 | ALA3877303 | cell-based format | Scientific Literature | |
5. | ALA3879102 | F | Induction of apoptosis in human GISTT1 cells assessed as increase in cleaved caspase-3 level at 1 uM by Western blot analysis | Homo sapiens | 1 | ALA3877303 | cell-based format | Scientific Literature | |
6. | ALA3879105 | F | Induction of apoptosis in human GISTT1 cells assessed as cleavage of PARP at 0.1 to 3 uM by Western blot analysis | Homo sapiens | 1 | ALA3877303 | cell-based format | Scientific Literature | |
7. | ALA3879106 | F | Induction of apoptosis in human GISTT1 cells assessed as cleavage of PARP at 1 uM by Western blot analysis | Homo sapiens | 1 | ALA3877303 | cell-based format | Scientific Literature | |
8. | ALA4012643 | F | Antiproliferative activity against human GISTT1 cells assessed as cell growth inhibition after 72 hrs by cell titer-glo assay | Homo sapiens | 2 | ALA4011618 | cell-based format | Scientific Literature | |
9. | ALA4012706 | F | Induction of apoptosis in human GISTT1 cells xenografted in nu/nu mouse at 25 to 100 mg/kg, ip administered daily for 28 days by TUNEL-staining based microscopic analysis | Homo sapiens | 1 | ALA4011618 | organism-based format | Scientific Literature | |
10. | ALA4012710 | F | Antitumor activity against human GISTT1 cells xenografted in nu/nu mouse assessed as tumor growth inhibition at 100 mg/kg, ip administered daily for 28 days relative to control | Homo sapiens | 2 | ALA4011618 | organism-based format | Scientific Literature | |
11. | ALA4012711 | F | Antitumor activity against human GISTT1 cells xenografted in nu/nu mouse assessed as tumor growth inhibition at 25 mg/kg, ip administered daily for 28 days relative to control | Homo sapiens | 1 | ALA4011618 | organism-based format | Scientific Literature | |
12. | ALA4012712 | F | Antitumor activity against human GISTT1 cells xenografted in nu/nu mouse assessed as reduction in tumor cell proliferation at 25 to 100 mg/kg, ip administered daily for 28 days by KI-67-staining based microscopic analysis | Homo sapiens | 1 | ALA4011618 | organism-based format | Scientific Literature | |
13. | ALA4020525 | F | Cytotoxicity against human GISTT1 cells assessed as cell growth inhibition after 72 hrs by CellTiterGlo assay | Homo sapiens | 28 | ALA4017543 | cell-based format | Scientific Literature | |
14. | ALA4020526 | F | Cytotoxicity against human GISTT1 cells harboring KIT T670I mutant assessed as cell growth inhibition after 72 hrs by CellTiterGlo assay | Homo sapiens | 28 | ALA4017543 | cell-based format | Scientific Literature | |
15. | ALA4020527 | F | Cytotoxicity against human GISTT1 cells harboring KIT D816E mutant assessed as cell growth inhibition after 72 hrs by CellTiterGlo assay | Homo sapiens | 28 | ALA4017543 | cell-based format | Scientific Literature | |
16. | ALA4264041 | F | Antiproliferative activity against human GISTT1 cells after 72 hrs by Celltiter-Glo assay | Homo sapiens | 2 | ALA4261600 | cell-based format | Scientific Literature | |
17. | ALA4305132 | F | Antiproliferative activity against human GISTT1 cells harboring c-KIT 560 to 578 deletion mutant incubated for 72 hrs by CCK8 assay | Homo sapiens | 2 | ALA4304743 | cell-based format | Scientific Literature | |
18. | ALA4305134 | F | Antiproliferative activity against human GISTT1 cells harboring c-KIT 560 to 578 deletion/T670I double mutant incubated for 72 hrs by CCK8 assay | Homo sapiens | 2 | ALA4304743 | cell-based format | Scientific Literature | |
19. | ALA4305161 | F | Induction of apoptosis in human GISTT1 cells harboring c-KIT 560 to 578 deletion mutant assessed as increase in cleaved PARP level after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4304743 | cell-based format | Scientific Literature | |
20. | ALA4305162 | F | Induction of apoptosis in human GISTT1 cells harboring c-KIT 560 to 578 deletion/T670I double mutant assessed as increase in cleaved PARP level after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4304743 | cell-based format | Scientific Literature |