# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4371233 | F | Antitumor activity against mouse GL261 cells implanted in mouse assessed as incidence of long term survival (>100 days) at 30 mg/kg, po qd relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
2. | ALA4394269 | F | Cytotoxicity against mouse GL261 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay | Mus musculus | 12 | cell-based format | Scientific Literature | ||
3. | ALA4394270 | F | Cytotoxicity against mouse GL261 cells assessed as reduction in cell viability at 0.1 to 100 uM incubated for 48 hrs by MTS assay | Mus musculus | 3 | cell-based format | Scientific Literature | ||
4. | ALA4394271 | F | Induction of apoptosis in mouse GL261 cells assessed as reduction in cell viability at 10 uM incubated for 48 hrs by annexinV-PE/7-AAD staining based flow cytometric analysis | Mus musculus | 3 | cell-based format | Scientific Literature | ||
5. | ALA4394272 | F | Induction of apoptosis in mouse GL261 cells assessed as increase in early apoptotic cells at 10 uM incubated for 48 hrs by annexinV-PE/7-AAD staining based flow cytometric analysis | Mus musculus | 3 | cell-based format | Scientific Literature | ||
6. | ALA4394273 | F | Induction of apoptosis in mouse GL261 cells assessed as increase in late apoptotic cells at 10 uM incubated for 48 hrs by annexinV-PE/7-AAD staining based flow cytometric analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
7. | ALA4394274 | F | Induction of apoptosis in mouse GL261 cells assessed as increase in necrotic cells at 10 uM incubated for 48 hrs by annexinV-PE/7-AAD staining based flow cytometric analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
8. | ALA4394278 | F | Induction of morphological changes in mouse GL261 cells assessed as increase in cell circularity at 10 uM incubated for 48 hrs by Hoechst 33258 staining based fluorescence microscopic analysis | Mus musculus | 4 | cell-based format | Scientific Literature | ||
9. | ALA4394279 | F | Induction of morphological changes in mouse GL261 cells assessed as decrease in cell aspect ratio at 10 uM incubated for 48 hrs by Hoechst 33258 staining based fluorescence microscopic analysis | Mus musculus | 4 | cell-based format | Scientific Literature | ||
10. | ALA4394280 | F | Antiinvasive activity in mouse GL261 cells assessed as reduction in cell migration at 10 uM preincubated for 48 hrs and measured after 6 hrs by giemsa staining based Boyden chamber assay | Mus musculus | 4 | cell-based format | Scientific Literature | ||
11. | ALA4419839 | F | Cytotoxicity in mouse GL261 cells assessed as reduction in cell viability incubated for 2 to 4 days by Trypan blue exclusion based hemocytometry | Mus musculus | 1 | cell-based format | Patent Bioactivity Data | ||
12. | ALA4419863 | F | Antitumor activity against mouse GL261 cells implanted in mouse syngeneic immunocompetent tumor model assessed as median mouse survival at 50 mg/kg dosed via daily oral gavage starting 6 days post-tumor implantation and measured up to 100 days post tumor implantation (Rvb = 36 days) | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
13. | ALA4419864 | F | Antitumor activity against mouse GL261 cells implanted in mouse syngeneic immunocompetent tumor model assessed as reduction in tumor size at 50 mg/kg dosed via daily oral gavage starting 6 days post-tumor implantation and measured up to 100 days post tumor implantation by magnetic resonance imaging analysis | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
14. | ALA4419869 | F | Antitumor activity against mouse GL261 cells implanted in mouse syngeneic immunocompetent tumor model assessed as reduction in tumor volume at 100 mg/kg dosed via daily oral gavage starting 6 days post-tumor implantation and measured up to 100 days post tumor implantation | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
15. | ALA4419882 | F | Cytotoxicity in mouse GL261 cells assessed as reduction in cell viability at 10 uM in presence of 10 uM chloroquine incubated for 2 to 4 days by Trypan blue exclusion based hemocytometry | Mus musculus | 1 | cell-based format | Patent Bioactivity Data | ||
16. | ALA5029877 | F | Cytotoxicity against mouse GL261 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay | Mus musculus | 16 | cell-based format | Scientific Literature | ||
17. | ALA5029879 | F | Antimigratory activity against mouse GL261 cells assessed as reduction in wound closure at 12.5 uM measured up to 24 hrs by scratch wound healing assay (Rvb =63.3+/-0.78%) | Mus musculus | 1 | cell-based format | Scientific Literature | ||
18. | ALA5029881 | F | Antimigratory activity against mouse GL261 cells assessed as inhibition of cell migration measured after 24 hrs by crystal violet staining based inverted microscopic analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
19. | ALA5029883 | F | Antiinvasive activity against mouse GL261 cells assessed as inhibition of cell invasion measured after 24 hrs by crystal violet staining based inverted microscopic analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
20. | ALA5029885 | F | Induction of apoptosis in mouse GL261 cells assessed as viable cells at 25 uM measured after 24 hrs by annexin V-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 96.1%) | Mus musculus | 1 | cell-based format | Scientific Literature |