| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4193351 | F | Cytoprotection in rat INS1(832/13) cells assessed as reduction in streptozocin induced beta cells apoptosis after 20 hrs by MTT based spectrophotometric method | Rattus norvegicus | 4 | ALA4190311 | cell-based format | Scientific Literature | |
| 2. | ALA4193352 | F | Cytoprotection in rat INS1(832/13) cells assessed as reduction in streptozocin induced beta cells apoptosis after 20 hrs by MTT based spectrophotometric method relative to control | Rattus norvegicus | 4 | ALA4190311 | cell-based format | Scientific Literature | |
| 3. | ALA4379980 | A | Cytotoxicity against rat INS1(832/13) cells assessed as cell viability at 3.5 nM in RPMI medium incubated for over night followed by insulin addition by Alamar Blue assay | Rattus norvegicus | 2 | ALA4376848 | cell-based format | Scientific Literature | |
| 4. | ALA4379986 | A | Cytotoxicity against rat INS1(832/13) cells assessed as cell viability upto 3 nM in RPMI medium incubated for over night followed by insulin addition by Alamar Blue assay | Rattus norvegicus | 2 | ALA4376848 | cell-based format | Scientific Literature | |
| 5. | ALA4379987 | F | Antidiabetic activity in glucose-treated rat INS1(832/13) cells assessed as increase in insulin release at 1 nM in presence of 3 mM glucose measured after 2 hrs by radioimmunoassay (Rvb = 52.25 +/- 2.15 %) | Rattus norvegicus | 4 | ALA4376848 | cell-based format | Scientific Literature | |
| 6. | ALA4379988 | F | Antidiabetic activity in glucose-treated rat INS1(832/13) cells assessed as increase in insulin release at 1.5 to 5 nM in presence of 3 mM glucose measured after 2 hrs by radioimmunoassay (Rvb = 52.25 +/- 2.15 %) | Rattus norvegicus | 4 | ALA4376848 | cell-based format | Scientific Literature | |
| 7. | ALA4379989 | F | Antidiabetic activity in glucose-treated rat INS1(832/13) cells assessed as increase in insulin release at 1 ug/ml in presence of 3 mM glucose measured after 2 hrs by radioimmunoassay (Rvb = 52.25 +/- 2.15 %) | Rattus norvegicus | 1 | ALA4376848 | cell-based format | Scientific Literature | |
| 8. | ALA4379990 | F | Antidiabetic activity in glucose-treated rat INS1(832/13) cells assessed as increase in insulin release in presence of 3 mM glucose measured after 2 hrs by radioimmunoassay | Rattus norvegicus | 5 | ALA4376848 | cell-based format | Scientific Literature | |
| 9. | ALA4379991 | F | Antidiabetic activity in glucose-treated rat INS1(832/13) cells assessed as increase in insulin release at 10 ug/ml in presence of 3 mM glucose measured after 2 hrs by radioimmunoassay (Rvb = 52.25 +/- 2.15 %) | Rattus norvegicus | 1 | ALA4376848 | cell-based format | Scientific Literature | |
| 10. | ALA4683511 | F | Cytoprotective activity in rat INS-1 832/13 cells assessed as inhibition of STZ-induced apoptosis at 20 uM incubated for 24 hrs by MTT assay relative to control | Rattus norvegicus | 51 | ALA4680150 | cell-based format | Scientific Literature | |
| 11. | ALA4683512 | F | Cytoprotective activity in rat INS-1 832/13 cells assessed as inhibition of STZ-induced apoptosis incubated for 24 hrs by MTT assay | Rattus norvegicus | 37 | ALA4680150 | cell-based format | Scientific Literature | |
| 12. | ALA4683513 | F | Potency index, ratio of vincamine EC50 to test compound EC50 for cytoprotective activity in rat INS-1 832/13 cells assessed as inhibition of STZ-induced apoptosis | Rattus norvegicus | 2 | ALA4680150 | cell-based format | Scientific Literature | |
| 13. | ALA4683514 | F | Cytoprotective activity against STZ-induced toxicity in rat INS-1 832/13 cells at 10 uM incubated for 24 hrs by MTT assay | Rattus norvegicus | 2 | ALA4680150 | cell-based format | Scientific Literature | |
| 14. | ALA4683515 | F | Cytoprotective activity against STZ-induced toxicity in rat INS-1 832/13 cells at 20 uM incubated for 24 hrs by MTT assay | Rattus norvegicus | 1 | ALA4680150 | cell-based format | Scientific Literature | |
| 15. | ALA4683516 | F | Cytoprotective activity against STZ-induced toxicity in rat INS-1 832/13 cells assessed as mass of apoptotic cells at 20 uM by Annexin V-FITC staining based flow cytometric analysis (Rvb = 40.8%) | Rattus norvegicus | 3 | ALA4680150 | cell-based format | Scientific Literature | |
| 16. | ALA4683517 | F | Cytoprotective activity against STZ-induced toxicity in rat INS-1 832/13 cells assessed as mass of apoptotic cells at 5 uM by Annexin V-FITC staining based flow cytometric analysis (Rvb = 40.8%) | Rattus norvegicus | 2 | ALA4680150 | cell-based format | Scientific Literature | |
| 17. | ALA4683518 | F | Cytoprotective activity against STZ-induced toxicity in rat INS-1 832/13 cells assessed as mass of apoptotic cells at 10 uM by Annexin V-FITC staining based flow cytometric analysis (Rvb = 40.8%) | Rattus norvegicus | 2 | ALA4680150 | cell-based format | Scientific Literature | |
| 18. | ALA4683523 | F | Cytoprotective activity in rat INS-1 832/13 cells assessed as inhibition of STZ-induced apoptosis at 20 uM incubated for 24 hrs in presence of wortmannin by MTT assay | Rattus norvegicus | 3 | ALA4680150 | cell-based format | Scientific Literature | |
| 19. | ALA4683531 | F | Cytoprotective activity against STZ-induced rat INS-1 832/13 cells assessed as increase in IRS2 protein expression at 5 to 20 uM after 24 hrs Western blot analysis | Rattus norvegicus | 2 | ALA4680150 | cell-based format | Scientific Literature | |
| 20. | ALA4683532 | F | Cytoprotective activity against STZ-induced rat INS-1 832/13 cells assessed as increase in IRS2 mRNA expression at 5 to 20 uM after 24 hrs RT-PCR analysis | Rattus norvegicus | 2 | ALA4680150 | cell-based format | Scientific Literature |
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