# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4005408 | Functional | Antileukemic activity against human K562-IMA[r] cells after 48 hrs by XTT assay | Homo sapiens | 1 | ALA4004814 | cell-based format | Scientific Literature | |
2. | ALA4376383 | Functional | Induction of sensitization to imatinib-induced cytotoxicity in imatinib-resistant human K562-IMA[r] cells assessed as induction of cell death at 10 uM after 72 hrs in presence of 1 uM imatinib by propidium iodide/Triton-X100 dye based FACS analysis | Homo sapiens | 16 | ALA4373734 | cell-based format | Scientific Literature | |
3. | ALA4376384 | ADME | Cytotoxicity against imatinib-resistant human K562-IMA[r] cells assessed as induction of cell death at 10 uM after 72 hrs by propidium iodide/Triton-X100 dye based FACS analysis relative to control | Homo sapiens | 6 | ALA4373734 | cell-based format | Scientific Literature | |
4. | ALA4376385 | ADME | Cytotoxicity against imatinib-resistant human K562-IMA[r] cells assessed as cell death at 10 uM after 72 hrs by propidium iodide/Triton-X100 dye based FACS analysis | Homo sapiens | 15 | ALA4373734 | cell-based format | Scientific Literature | |
5. | ALA4376386 | Functional | Induction of sensitization to imatinib-induced cytotoxicity in imatinib-resistant human K562-IMA[r] cells assessed as cell death at 0.1 to 10 uM measured after 72 hrs in presence of 1 uM imatinib by propidium iodide/Triton-X100 dye based FACS analysis | Homo sapiens | 1 | ALA4373734 | cell-based format | Scientific Literature | |
6. | ALA4376387 | Functional | Induction of sensitization to imatinib induced cytotoxicity in imatinib-resistant human K562-IMA[r] cells assessed as cell death up to 2.5 uM measured after 72 hrs in presence of of 1 uM imatinib by propidium iodide/Triton-X100 dye based FACS analysis | Homo sapiens | 6 | ALA4373734 | cell-based format | Scientific Literature | |
7. | ALA4376388 | Functional | Induction of sensitization to imatinib-induced cytotoxicity in imatinib-resistant human K562-IMA[r] cells assessed as gain in cell death rate at 5 uM measured after 72 hrs in presence of 1 uM imatinib by propidium iodide/Triton-X100 dye based FACS analysis relative to imatinib-treated control | Homo sapiens | 6 | ALA4373734 | cell-based format | Scientific Literature | |
8. | ALA4376392 | Functional | Decrease in STAT5 expression in imatinib-resistant human K562-IMA[r] cells at 10 uM after 24 hrs in presence of 1 uM imatinib by Western blot analysis | Homo sapiens | 2 | ALA4373734 | cell-based format | Scientific Literature | |
9. | ALA4376394 | Functional | Induction of sensitization to imatinib-induced cytotoxicity in imatinib-resistant human K562-IMA[r] cells assessed as induction of cell death at 10 uM after 72 hrs in presence of 1 uM imatinib by propidium iodide/Triton-X100 dye based FACS analysis (Rvb = 15%) | Homo sapiens | 6 | ALA4373734 | cell-based format | Scientific Literature | |
10. | ALA4376395 | Functional | Induction of sensitization to imatinib-induced cytotoxicity in imatinib-resistant human K562-IMA[r] cells assessed as induction of cell death measured after 72 hrs in presence of 1 uM imatinib by propidium iodide/Triton-X100 dye based FACS analysis | Homo sapiens | 6 | ALA4373734 | cell-based format | Scientific Literature |