# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1073505 | F | Effect on IKKalpha protein level in human KBM5 cells at 100 uM by Western blot analysis | Homo sapiens | 1 | ALA1157701 | cell-based format | Scientific Literature | |
2. | ALA1073506 | F | Effect on IKK-beta protein level in human KBM5 cells at 100 uM by Western blot analysis | Homo sapiens | 1 | ALA1157701 | cell-based format | Scientific Literature | |
3. | ALA1073509 | F | Inhibition of Bcl-2 protein expression in TNF-alpha-stimulated human KBM5 cells at 100 uM after 6 to 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA1157701 | cell-based format | Scientific Literature | |
4. | ALA1072117 | F | Induction of apoptosis in human KBM5 cells harboring wild type Bcr-Abl assessed as PARP cleavage at 50 to 100 uM after 18 hrs by Western blot analysis | Homo sapiens | 4 | ALA1157578 | cell-based format | Scientific Literature | |
5. | ALA1072118 | F | Induction of apoptosis in human KBM5 cells harboring Bcr-Abl T315I mutant assessed as PARP cleavage at 50 to 100 uM after 18 hrs by Western blot analysis | Homo sapiens | 4 | ALA1157578 | cell-based format | Scientific Literature | |
6. | ALA4316282 | F | Cytotoxicity against human KBM5 cells expressing IM- sensitive wild type Bcr/Abl assessed as reduction in cell viability incubated for 48 hrs by MTT assay | Homo sapiens | 6 | ALA4312029 | cell-based format | Scientific Literature | |
7. | ALA4316283 | F | Cytotoxicity against human KBM5 cells expressing IM-resistant Bcr/Abl T315I mutant assessed as reduction in cell viability incubated for 48 hrs by MTT assay | Homo sapiens | 6 | ALA4312029 | cell-based format | Scientific Literature | |
8. | ALA4316311 | F | Potentiation of NLT-induced apoptotic cell death in human KBM5 cells expressing IM-sensitive wild type Bcr/Abl at 10 nM co-incubated with NLT for 48 hrs by Annexin V-staining based flow cytometry | Homo sapiens | 1 | ALA4312029 | cell-based format | Scientific Literature | |
9. | ALA4316312 | F | Potentiation of NLT-induced apoptotic cell death in human KBM5 cells expressing IM-resistant Bcr/Abl T315I mutant at 10 nM co-incubated with NLT for 48 hrs by Annexin V-staining based flow cytometry | Homo sapiens | 1 | ALA4312029 | cell-based format | Scientific Literature | |
10. | ALA4316313 | F | Induction of apoptotic cell death in human KBM5 cells expressing IM-sensitive wild type Bcr/Abl at 10 nM incubated for 48 hrs by Annexin V-staining based flow cytometry | Homo sapiens | 2 | ALA4312029 | cell-based format | Scientific Literature | |
11. | ALA4316314 | F | Induction of apoptotic cell death in human KBM5 cells expressing IM-resistant Bcr/Abl T315I mutant at 10 nM incubated for 48 hrs by Annexin V-staining based flow cytometry | Homo sapiens | 2 | ALA4312029 | cell-based format | Scientific Literature | |
12. | ALA4364443 | F | Growth inhibition of human KBM5 cells relative to control | Homo sapiens | 3 | ALA4364241 | cell-based format | Scientific Literature | |
13. | ALA4838802 | F | Cytotoxicity against Imatinib mesylate sensitive wild-type human KBM5 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay | Homo sapiens | 4 | ALA4837226 | cell-based format | Scientific Literature | |
14. | ALA4838803 | F | Cytotoxicity against imatinib mesylate resistant wild-type human KBM5 cells expressing T315I mutant assessed as cell growth inhibition measured after 48 hrs by MTT assay | Homo sapiens | 4 | ALA4837226 | cell-based format | Scientific Literature | |
15. | ALA4838805 | F | Potentiation of ponatinib-induced apoptosis human KBM5 cells assessed as increase in apoptotic cells at 5 nM measured after 48 hrs by annexin V staining based flow cytometry analysis | Homo sapiens | 1 | ALA4837226 | cell-based format | Scientific Literature | |
16. | ALA4838806 | F | Potentiation of ponatinib-induced apoptosis human KBM5 cells expressing T315I mutant assessed as increase in apoptotic cells at 5 nM measured after 48 hrs by annexin V staining based flow cytometry analysis (Rvb = 35 %) | Homo sapiens | 1 | ALA4837226 | cell-based format | Scientific Literature | |
17. | ALA4838807 | F | Potentiation of ponatinib-induced mitochondrial membrane depolarization in human KBM5 cells expressing T315I mutant at 5 nM measured upto 48 hrs by JC-1 staining based flow cytometry analysis | Homo sapiens | 1 | ALA4837226 | cell-based format | Scientific Literature | |
18. | ALA4838808 | F | Potentiation of ponatinib-induced mitochondrial membrane depolarization in human KBM5 cells expressing T315I mutant at 5 nM in the presence of ponatinib measured upto 48 hrs by JC-1 staining based flow cytometry analysis (Rvb= 32.7 %) | Homo sapiens | 1 | ALA4837226 | cell-based format | Scientific Literature | |
19. | ALA4838810 | F | Induction of apoptosis in human KBM5 cells expressing T315I mutant assessed as decrease in Mcl-2 expression at 1 to 10 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4837226 | cell-based format | Scientific Literature | |
20. | ALA4838811 | F | Induction of apoptosis in human KBM5 cells expressing T315I mutant assessed as increase in cytochrome C expression at 1 to 10 uM measured after 24 hrs by western blot analysis | Homo sapiens | 1 | ALA4837226 | cell-based format | Scientific Literature |