| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA928088 | F | Inhibition of PMA/ionomycin-induced PDG2 synthesis in human LAD2 cells | Homo sapiens | 1 | ALA1142434 | cell-based format | Scientific Literature | |
| 2. | ALA2019769 | F | Inhibition of IgE-mediated human LAD2 cell degranulation assessed as beta-hexosaminidase release using p-nitrophenyl-N-acetyl-D-glucosamide as substrate preincubated for 30 mins measured 90 mins after substrate addition by spectrophotometric analysis | Homo sapiens | 23 | ALA2016552 | cell-based format | Scientific Literature | |
| 3. | ALA2019868 | F | Inhibition of IgE-mediated human LAD2 cell degranulation assessed as beta-hexosaminidase release using p-nitrophenyl-N-acetyl-D-glucosamide as substrate at 1 uM preincubated for 30 mins measured 90 mins after substrate addition by spectrophotometric analysis | Homo sapiens | 4 | ALA2016552 | cell-based format | Scientific Literature | |
| 4. | ALA2072028 | F | Inhibition of human LAD2 cells degranulation at 1 uM preincubated for 30 mins before streptavidin stimulation measured after 30 mins by measuring beta-hexosaminidase activity | Homo sapiens | 1 | ALA2069193 | cell-based format | Scientific Literature | |
| 5. | ALA2072029 | F | Inhibition of human LAD2 cells degranulation preincubated for 30 mins before streptavidin stimulation measured after 30 mins by measuring beta-hexosaminidase activity | Homo sapiens | 11 | ALA2069193 | cell-based format | Scientific Literature | |
| 6. | ALA2388053 | F | Inhibition of human LAD2 mast cell activation assessed as compound 48/80-induced degranulation at 10 to 20 uM incubated for 30 mins prior to compound 48/80 challenge by beta-hexosaminidase release assay in presence of UV light | Homo sapiens | 2 | ALA2384912 | cell-based format | Scientific Literature | |
| 7. | ALA2388054 | F | Inhibition of human LAD2 mast cell activation assessed as compound 48/80-induced degranulation at 200 to 400 uM incubated for 30 mins prior to compound 48/80 challenge by beta-hexosaminidase release assay in presence of UV light | Homo sapiens | 1 | ALA2384912 | cell-based format | Scientific Literature | |
| 8. | ALA2388055 | F | Inhibition of human LAD2 mast cell activation assessed as compound 48/80-induced degranulation at 10 to 20 uM incubated for 30 mins prior to compound 48/80 challenge by beta-hexosaminidase release assay | Homo sapiens | 2 | ALA2384912 | cell-based format | Scientific Literature | |
| 9. | ALA2388056 | F | Inhibition of human LAD2 mast cell activation assessed as compound 48/80-induced degranulation at 200 to 400 uM incubated for 30 mins prior to compound 48/80 challenge by beta-hexosaminidase release assay | Homo sapiens | 1 | ALA2384912 | cell-based format | Scientific Literature | |
| 10. | ALA2388057 | F | Inhibition of human LAD2 mast cell activation assessed as compound 48/80-induced degranulation at 100 uM incubated for 30 mins prior to compound 48/80 challenge by histamine release assay | Homo sapiens | 2 | ALA2384912 | cell-based format | Scientific Literature | |
| 11. | ALA2388058 | F | Inhibition of human LAD2 mast cell activation assessed as compound 48/80-induced degranulation at 1000 uM incubated for 30 mins prior to compound 48/80 challenge by beta-hexosaminidase release assay | Homo sapiens | 1 | ALA2384912 | cell-based format | Scientific Literature | |
| 12. | ALA2388059 | F | Inhibition of human LAD2 mast cell activation assessed as 1.0 uM compound 48/80-induced degranulation incubated for 30 mins prior to compound 48/80 challenge by beta-hexosaminidase release assay | Homo sapiens | 1 | ALA2384912 | cell-based format | Scientific Literature | |
| 13. | ALA2388060 | F | Inhibition of human LAD2 mast cell activation assessed as compound 48/80-induced degranulation at 10 uM incubated for 30 mins prior to compound 48/80 challenge by beta-hexosaminidase release assay | Homo sapiens | 1 | ALA2384912 | cell-based format | Scientific Literature | |
| 14. | ALA2388061 | F | Inhibition of human LAD2 mast cell activation assessed as 0.1 uM compound 48/80-induced degranulation incubated for 30 mins prior to compound 48/80 challenge by beta-hexosaminidase release assay | Homo sapiens | 1 | ALA2384912 | cell-based format | Scientific Literature | |
| 15. | ALA2388063 | F | Inhibition of human LAD2 mast cell activation assessed as compound 48/80-induced degranulation incubated for 30 mins prior to compound 48/80 challenge by beta-hexosaminidase release assay | Homo sapiens | 4 | ALA2384912 | cell-based format | Scientific Literature | |
| 16. | ALA3405049 | F | Inhibition of degranulation in human LAD2 cells assessed as inhibition of IgE-induced beta-hexosaminidase release preincubated for 30 mins by p-nitrophenyl-N-acetyl-D-glucosamide-based spectrophotometric assay | Homo sapiens | 3 | ALA3399948 | cell-based format | Scientific Literature | |
| 17. | ALA4326402 | A | Proinflammatory activity in human LAD2 cells assessed as increase in mast-cell degranulation by measuring beta-hexosaminidase release at 0.125 mM preincubated for 30 mins followed 4-nitrophenyl-N-acetyl-beta-D-glucosaminide substrate addition and measured after 90 mins by fluorescence-based microplate reader analysis relative to control | Homo sapiens | 1 | ALA4325834 | cell-based format | Scientific Literature | |
| 18. | ALA4326403 | A | Proinflammatory activity in human LAD2 cells assessed as increase in mast-cell degranulation by measuring beta-hexosaminidase release at 0.25 mM preincubated for 30 mins followed 4-nitrophenyl-N-acetyl-beta-D-glucosaminide substrate addition and measured after 90 mins by fluorescence-based microplate reader analysis relative to control | Homo sapiens | 1 | ALA4325834 | cell-based format | Scientific Literature | |
| 19. | ALA4326404 | A | Proinflammatory activity in human LAD2 cells assessed as increase in mast-cell degranulation by measuring beta-hexosaminidase release at 0.5 mM preincubated for 30 mins followed 4-nitrophenyl-N-acetyl-beta-D-glucosaminide substrate addition and measured after 90 mins by fluorescence-based microplate reader analysis relative to control | Homo sapiens | 1 | ALA4325834 | cell-based format | Scientific Literature | |
| 20. | ALA4326405 | A | Proinflammatory activity in human LAD2 cells assessed as increase in mast-cell degranulation by measuring beta-hexosaminidase release at 1 mM preincubated for 30 mins followed 4-nitrophenyl-N-acetyl-beta-D-glucosaminide substrate addition and measured after 90 mins by fluorescence-based microplate reader analysis relative to control | Homo sapiens | 1 | ALA4325834 | cell-based format | Scientific Literature |
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