# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4307405 | F | Antiviral activity against Zaire EBOV-Mayinga expressing GFP infected in human HeLa cells preincubated for 1 hr followed by viral infection after 24 hrs by DAPI-staining based fluorescence assay | Zaire ebolavirus | 1 | ALA4304791 | organism-based format | Scientific Literature | |
2. | ALA4307406 | F | Antiviral activity against Zaire EBOV-mayinga expressing GFP infected in human HeLa cells preincubated for 1 hr followed by viral infection after 24 hrs by DAPI-staining based fluorescence assay relative to control | Zaire ebolavirus | 1 | ALA4304791 | organism-based format | Scientific Literature | |
3. | ALA4307409 | F | Potency index, ratio of ABMA EC50 to compound EC50 for antiviral activity against Zaire Ebola virus -Mayinga expressing GFP infected in human HeLa cells | Zaire ebolavirus | 1 | ALA4304791 | organism-based format | Scientific Literature | |
4. | ALA4330374 | F | Antiviral activity against Ebolavirus Mayinga infected in ip dosed Balb/c mouse assessed as protection against viral infection administered 2 hrs prior to viral infection daily for 6 days and measured for 14 days | Zaire ebolavirus | 1 | ALA4330057 | organism-based format | Scientific Literature | |
5. | ALA4330375 | F | Antiviral activity against Ebolavirus Mayinga infected in Balb/c mouse assessed as protection against viral infection by measuring host survival at 10 mg/kg, ip administered 2 hrs prior to viral infection daily for 6 days and measured for 14 days relative to control | Zaire ebolavirus | 2 | ALA4330057 | organism-based format | Scientific Literature | |
6. | ALA4330376 | F | Antiviral activity against Ebolavirus Mayinga infected in Balb/c mouse assessed as protection against viral infection at 1 to 5 mg/kg, ip administered 2 hrs prior to viral infection daily for 6 days and measured for 14 days relative to control | Zaire ebolavirus | 1 | ALA4330057 | organism-based format | Scientific Literature | |
7. | ALA4330383 | F | Antiviral activity against VSV pseudotyped Ebolavirus Mayinga expressing GFP infected in human HeLa cells assessed as inhibition of viral infection at 2 uM pre-incubated for 2 hrs followed by viral infection and measured after 8 hrs by cell mask deep red staining based assay | Zaire ebolavirus | 2 | ALA4330057 | organism-based format | Scientific Literature | |
8. | ALA4330385 | F | Antiviral activity against VSV pseudotyped Ebolavirus Mayinga expressing GFP infected in human HeLa cells assessed as inhibition of viral infection up to 50 uM pre-incubated for 2 hrs followed by viral infection and measured after 8 hrs by high content imaging analysis | Zaire ebolavirus | 2 | ALA4330057 | organism-based format | Scientific Literature | |
9. | ALA4330389 | F | Antiviral activity against VSV pseudotyped Ebolavirus Mayinga expressing GFP infected in human HeLa cells assessed as inhibition of viral infection at 10 uM pre-incubated for 2 hrs followed by viral infection and measured after 8 hrs by cell mask deep red staining based assay | Zaire ebolavirus | 2 | ALA4330057 | organism-based format | Scientific Literature | |
10. | ALA4621283 | F | Antiviral activity against Ebola virus 1976 Mayinga infected in human HeLa cells pretreated for 1 hr followed by virus infection measured after 24 hrs by Hoechst staining-based immunofluorescence assay | Zaire ebolavirus | 12 | ALA4619772 | organism-based format | Scientific Literature | |
11. | ALA4621284 | F | Antiviral activity against Ebola virus 1976 Mayinga infected in African green monkey Vero cells pretreated for 1 hr followed by virus infection measured after 24 hrs by Hoechst staining-based immunofluorescence assay | Zaire ebolavirus | 1 | ALA4619772 | organism-based format | Scientific Literature | |
12. | ALA4621296 | F | Antiviral activity against Ebola virus 1976 Mayinga infected in African green monkey Vero cells | Zaire ebolavirus | 1 | ALA4619772 | organism-based format | Scientific Literature | |
13. | ALA4670542 | F | Antiviral activity against pseudotyped Ebola virus - Mayinga, Zaire infected in human A549 cells assessed as reduction in viral infection incubated for 48 hrs by luciferase reporter gene assay | Zaire ebolavirus | 31 | ALA4665793 | organism-based format | Scientific Literature | |
14. | ALA4710518 | F | Antiviral activity against Zaire ebolavirus infected in African green monkey Vero cells assessed as inhibition of viral infection by measuring reduction in cell survival incubated for 10 days by neutral red dye based colorimetric analysis | Zaire ebolavirus | 7 | ALA4706564 | organism-based format | Scientific Literature | |
15. | ALA4723124 | F | Antiviral activity against Zaire Ebola virus infected in IFNAR-/- C57BL/6 mouse assessed as mouse survival at 300 mg/kg, po administered twice daily starting from day 6 post infection until day 13 post infection and measured at the end of 3 weeks | Zaire ebolavirus | 1 | ALA4715853 | organism-based format | Scientific Literature | |
16. | ALA4723125 | F | Antiviral activity against Zaire Ebola virus infected in African green monkey Vero E6 cells measured after 5 days by immunofocus assay | Zaire ebolavirus | 1 | ALA4715853 | organism-based format | Scientific Literature | |
17. | ALA4817812 | F | Antiviral activity against Zaire ebola virus infected in African green monkey Vero cells | Zaire ebolavirus | 3 | ALA4814022 | organism-based format | Scientific Literature | |
18. | ALA5098252 | F | Antiviral activity against Zaire ebolavirus infected in african green monkey assessed as reduction in viral infection preincubated for 1 hr followed by viral infection 1 hr and measured after 8 days by crystal violet staining based plaque assay | Zaire ebolavirus | 2 | ALA5096193 | organism-based format | Scientific Literature | |
19. | ALA5131849 | F | Antiviral activity against ZEBOV at 5 uM | Zaire ebolavirus | 2 | ALA5131375 | organism-based format | Scientific Literature | |
20. | ALA5246344 | F | Antiviral activity against Zaire ebolavirus infected in African green monkey Vero cells assessed as reduction in virus induced cytopathic effect preincubated with cells for 1 hr followed by viral infection and measured after 48 hrs | Zaire ebolavirus | 1 | ALA5244259 | organism-based format | Scientific Literature |