Antimicrobial activity against Litomosoides sigmodontis L3 larvae stage infected in BALB/c mouse assessed as reduction in Wolbachia load by measuring reduction in FtsZ/actin gene ratio at 50 mg/kg, po administered BID for 28 days and measured 64 to 77 days post infection by qPCR analysis relative to control
Antimicrobial activity against Litomosoides sigmodontis L3 larvae stage infected in BALB/c mouse assessed as reduction in Wolbachia load by measuring reduction in FtsZ/actin gene ratio at 50 mg/kg, po administered BID for 14 days and measured 64 to 77 days post infection by qPCR analysis relative to control
Antimicrobial activity against Litomosoides sigmodontis L3 larvae stage infected in BALB/c mouse assessed as reduction in Wolbachia load by measuring reduction in FtsZ/actin gene ratio at 40 mg/kg, po administered BID for 28 days and measured 64 to 77 days post infection by qPCR analysis relative to control
Antimicrobial activity against Litomosoides sigmodontis L3 larvae stage infected in BALB/c mouse assessed as reduction in Wolbachia load by measuring reduction in FtsZ/actin gene ratio at 40 mg/kg, po administered BID for 14 days and measured 64 to 77 days post infection by qPCR analysis relative to control
Antiparasitic activity against Litomosoides sigmodontis infected in BALB/c mouse assessed as reduction in worm burden at 30 mg/kg, po TID administered for 5 days
Antiparasitic activity against Litomosoides sigmodontis infected in BALB/c mouse assessed as reduction in worm burden at 10 mg/kg, po qd administered for 7 days
Antiparasitic activity against Litomosoides sigmodontis infected in BALB/c mouse assessed as reduction in worm burden at 30 mg/kg, po BID administered for 7 days
Antiparasitic activity against Litomosoides sigmodontis infected in BALB/c mouse assessed as reduction in worm burden at 30 mg/kg, po BID administered for 6 days
Antiparasitic activity against Litomosoides sigmodontis infected in BALB/c mouse assessed as reduction in worm burden at 2 mg/kg, sc qd administered for 5 days
Antiparasitic activity against Litomosoides sigmodontis infected in BALB/c mouse assessed as reduction in worm burden at 30 mg/kg, sc BID administered for 7 days
Antiparasitic activity against Litomosoides sigmodontis infected in Meriones assessed as reduction in worm burden at 15 mg/kg, sc BID administered for 7 days
Antiparasitic activity against Litomosoides sigmodontis infected in Meriones assessed as reduction in worm burden at 2 mg/kg, sc qd administered for 5 days