# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3370204 | Functional | Potency index, ratio of IC50 for Retro-2(cycl) to IC50 for test compound against JC polyomavirus Mad1-SVEdelta infected in SVG-A cells assessed as reduction in viral infectivity pre-incubated for 0.5 hrs with compound before viral infection for 72 hrs by flow cytometry | JC polyomavirus | 1 | ALA3351579 | cell-based format | Scientific Literature | |
2. | ALA3370205 | Functional | Inhibition of retrograde transport of JC polyomavirus Mad1-SVEdelta infected in SVG-A cells assessed as reduction in co-localization of viral capsid protein VP1 and ER protein PDI pre-incubated for 0.5 hrs with compound before viral infection for 1 hr followed by incubation with compound at 0.05 mM for 8 hrs by proximity ligation assay | JC polyomavirus | 1 | ALA3351579 | cell-based format | Scientific Literature | |
3. | ALA3374946 | Functional | Inhibition of retrograde transport of JC polyomavirus Mad1-SVEdelta infected in SVG-A cells assessed as reduction in co-localization of viral capsid protein VP1 and ER protein PDI pre-incubated for 0.5 hrs with compound before viral infection for 1 hr followed by incubation with compound at 0.1 mM for 8 hrs by proximity ligation assay | JC polyomavirus | 1 | ALA3351579 | cell-based format | Scientific Literature | |
4. | ALA4428656 | Functional | Antiviral activity against JC polyomavirus infected in African green monkey G144 Vero cells assessed as reduction in late viral protein and viral capsid protein VP1 incubated for 72 hrs by branched DNA assay | JC polyomavirus | 14 | ALA4428043 | organism-based format | Scientific Literature |