# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4309431 | Binding | Inhibition of mouse kidney glutaminase assessed as ammonia formation using glutamine as substrate by Nessler's reagent based assay | Mus musculus | 1 | ALA4308839 | single protein format | Scientific Literature | |
2. | ALA4309433 | Binding | Inhibition of mouse kidney glutaminase assessed as ammonia formation at 0.1 uM using glutamine as substrate by Nessler's reagent based assay relative to control | Mus musculus | 6 | ALA4308839 | single protein format | Scientific Literature | |
3. | ALA4831625 | Functional | Invivo inhibition of GLS1 in BALB/c mouse xenografted with human HCT-116 cells assessed as increase in glutamine level at 200 mg/kg, po | Mus musculus | 1 | ALA4831477 | organism-based format | Scientific Literature | |
4. | ALA4831626 | Functional | Invivo inhibition of GLS1 in BALB/c mouse xenografted with human HCT-116 cells assessed as reduction in glutamate level at 200 mg/kg, po | Mus musculus | 1 | ALA4831477 | organism-based format | Scientific Literature | |
5. | ALA4831627 | Functional | Invivo inhibition of GLS1 in BALB/c mouse xenografted with human HCT-116 cells assessed as reduction in glutathione level at 200 mg/kg, po | Mus musculus | 1 | ALA4831477 | organism-based format | Scientific Literature | |
6. | ALA4831628 | Functional | Invivo inhibition of GLS1 in BALB/c mouse xenografted with human HCT-116 cells assessed as reduction in malate level at 200 mg/kg, po | Mus musculus | 1 | ALA4831477 | organism-based format | Scientific Literature | |
7. | ALA4831629 | Functional | Invivo inhibition of GLS1 in BALB/c mouse xenografted with human HCT-116 cells assessed as reduction in aspartate level at 200 mg/kg, po | Mus musculus | 1 | ALA4831477 | organism-based format | Scientific Literature | |
8. | ALA4831630 | Functional | Invivo inhibition of GLS1 in BALB/c mouse xenografted with human HCT-116 cells assessed as reduction in fumarate level at 200 mg/kg, po | Mus musculus | 1 | ALA4831477 | organism-based format | Scientific Literature | |
9. | ALA4831631 | Functional | Invivo inhibition of GLS1 in BALB/c mouse xenografted with human HCT-116 cells assessed as reduction in alpha-ketoglutarate level at 200 mg/kg, po | Mus musculus | 1 | ALA4831477 | organism-based format | Scientific Literature | |
10. | ALA5164959 | Binding | Inhibition of GLS1 in mouse kidney assessed as inhibition of glutamate production using glutamine as substrate incubated for 1 hr by coupled assay | Mus musculus | 1 | ALA5154870 | tissue-based format | Scientific Literature | |
11. | ALA5165026 | Binding | Inhibition of GLS1 in mouse brain assessed as inhibition of glutamate production using glutamine as substrate incubated for 1 hr by coupled assay | Mus musculus | 1 | ALA5154870 | tissue-based format | Scientific Literature | |
12. | ALA5258816 | Binding | Inhibition of GLS1 in mouse kidney extract at 1 mM relative to control | Mus musculus | 1 | ALA5257076 | tissue-based format | Scientific Literature | |
13. | ALA5258817 | Binding | Inhibition of GLS1 in mouse kidney extract at 10 mM relative to control | Mus musculus | 6 | ALA5257076 | tissue-based format | Scientific Literature | |
14. | ALA5258818 | Binding | Inhibition of mouse recombinant GLS1 glutaminase activity at 1 mM | Mus musculus | 1 | ALA5257076 | single protein format | Scientific Literature | |
15. | ALA5258819 | Binding | Inhibition of mouse recombinant GLS1 relative to control | Mus musculus | 4 | ALA5257076 | single protein format | Scientific Literature | |
16. | ALA5258822 | Binding | Inhibition of GLS1 in mouse kidney extract at 10 mM | Mus musculus | 14 | ALA5257076 | tissue-based format | Scientific Literature |