| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5252473 | B | Inhibition of full-length human DNMT2 expressed in bacteria using tRNA-Asp as substrate and 3H-SAM as cosubstrate by tritium incorporation assay | Homo sapiens | 29 | assay format | Scientific Literature | ||
| 2. | ALA5252474 | B | Binding affinity to human DNMT2 at 100 uM by tritium incorporation assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 3. | ALA5252475 | B | Displacement of FTAD from full-length human DNMT2 expressed in bacteria at 20 uM incubated for 10 mins by MST assay relative to control | Homo sapiens | 30 | assay format | Scientific Literature | ||
| 4. | ALA5252476 | B | Displacement of FTAD from full-length human DNMT2 expressed in Escherichia coli incubated for 10 mins by MST assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 5. | ALA5252477 | B | Displacement of FTAD from full-length human DNMT2 expressed in bacteria incubated for 10 mins by MST assay | Homo sapiens | 29 | assay format | Scientific Literature | ||
| 6. | ALA5252478 | B | Binding affinity to full-length human DNMT2 expressed in bacteria assessed as apparent dissociation constant by ITC method | Homo sapiens | 29 | assay format | Scientific Literature | ||
| 7. | ALA5252479 | B | Inhibition of full-length human DNMT2 expressed in bacteria using tRNA-Asp as substrate and [3H[-SAM as cosubstrate at 100 uM by tritium incorporation assay relative to control | Homo sapiens | 29 | assay format | Scientific Literature | ||
| 8. | ALA5252480 | B | Inhibition of full-length human DNMT2 expressed in bacteria in presence of DTT by tritium incorporation assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 9. | ALA5252485 | B | Binding affinity to human DNMT2 deletion mutant expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells incubated for 1 hr under denaturing condition by protein mass spectrometry | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA5252488 | B | Inhibition of human DNMT2 by tritium incorporation assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA5252489 | B | Inhibition of full-length human DNMT2 expressed in bacteria using tRNA-Asp as substrate and [3H[-SAM as cosubstrate at 100 uM by tritium incorporation assay | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 12. | ALA4379082 | B | Binding affinity to DNMT2 (unknown origin) at protein to compound concentration ratio of 1:20 by differential scanning fluorimetry | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA5136927 | B | Binding affinity to full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS at 100 uM incubated for 5 mins by microscale thermophoresis assay | Homo sapiens | 38 | assay format | Scientific Literature | ||
| 14. | ALA5136928 | B | Inhibition of full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS at 100 uM using tRNA asp as substrate and SAM as co-substrate incubated for 5 mins by tritium incorporation assay relative to control | Homo sapiens | 38 | assay format | Scientific Literature | ||
| 15. | ALA5136929 | B | Binding affinity to full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS assessed as dissociation constant at 100 uM by isothermal titration calorimetry assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 16. | ALA5136930 | B | Inhibition of full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS by isothermal titration calorimetry assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 17. | ALA5136932 | B | Binding affinity to full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS assessed as gibbs free energy change at 100 uM by isothermal titration calorimetry assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 18. | ALA5136933 | B | Binding affinity to full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS assessed as change in enthalpy change at 100 uM by isothermal titration calorimetry assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 19. | ALA5136934 | B | Binding affinity to full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS assessed as change in entropy at 100 uM by isothermal titration calorimetry assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 20. | ALA5136939 | B | Inhibition of full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS at 100 uM by liquid scintillation counting analysis | Homo sapiens | 6 | assay format | Scientific Literature |
The page will load shortly, Thanks for your patience!