# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4420791 | B | Inhibition of TM4SF5 in human SNU449Tp cells assessed as reduction in cell number at 5 to 40 uM incubated up to 2 days | Homo sapiens | 41 | ALA4420072 | cell-based format | Patent Bioactivity Data | |
2. | ALA4420792 | B | Inhibition of TM4SF5 in human SNU449Tp cells assessed as inhibition of S-phase progression at 20 uM followed by BrdU addition and incubated for 24 hrs by immunofluorescent staining | Homo sapiens | 1 | ALA4420072 | cell-based format | Patent Bioactivity Data | |
3. | ALA4420793 | B | Inhibition of TM4SF5 in human SNU449Tp cells assessed as restoration of cell-cell contact at 20 uM by E-cadherin and beta-catenin detection based immunofluorescent staining | Homo sapiens | 1 | ALA4420072 | cell-based format | Patent Bioactivity Data | |
4. | ALA4420795 | B | Inhibition of TM4SF5 in human SNU449Tp cells assessed as reduction in p27Kip1 expression by Western blotting analysis | Homo sapiens | 1 | ALA4420072 | cell-based format | Patent Bioactivity Data | |
5. | ALA4420796 | B | Inhibition of TM4SF5 in human SNU449Tp cells assessed as reduction in pS10 p27Kip1 expression by Western blotting analysis | Homo sapiens | 1 | ALA4420072 | cell-based format | Patent Bioactivity Data | |
6. | ALA4420797 | B | Inhibition of TM4SF5 in human SNU449Tp cells assessed as reduction in pY77 FAK expression by Western blotting analysis | Homo sapiens | 1 | ALA4420072 | cell-based format | Patent Bioactivity Data | |
7. | ALA4420798 | B | Inhibition of TM4SF5 in human SNU449Tp cells assessed as reduction in alpha-SMA expression by Western blotting analysis | Homo sapiens | 1 | ALA4420072 | cell-based format | Patent Bioactivity Data | |
8. | ALA4420799 | B | Inhibition of TM4SF5 in human SNU449Tp cells assessed as reduction in cytosolic p27Kip1 expression by immunofluorescent staining | Homo sapiens | 1 | ALA4420072 | cell-based format | Patent Bioactivity Data | |
9. | ALA4420800 | B | Inhibition of TM4SF5 in human SNU449Tp cells assessed as restoration of reduced RhoA activity | Homo sapiens | 1 | ALA4420072 | cell-based format | Patent Bioactivity Data | |
10. | ALA4420801 | B | Inhibition of TM4SF5 in human SNU449Tp cells assessed as induction of return of elongated cell shape to polygonal shape by DAPI staining based assay | Homo sapiens | 1 | ALA4420072 | cell-based format | Patent Bioactivity Data | |
11. | ALA4420802 | B | Inhibition of TM4SF5 in human SNU449Tp cells assessed as increase in sensitivity of N-linked glycosylated region of TM4SF5 to PNGase F | Homo sapiens | 1 | ALA4420072 | cell-based format | Patent Bioactivity Data | |
12. | ALA4420804 | B | Inhibition of TM4SF5 in human SNU368 cells assessed as reduction in cell number at 1 to 20 ug/ml incubated up to 3 days | Homo sapiens | 1 | ALA4420072 | cell-based format | Patent Bioactivity Data | |
13. | ALA4420805 | B | Inhibition of TM4SF5 in human HepG2 cells assessed as reduction in cell number at 1 to 20 ug/ml incubated up to 3 days | Homo sapiens | 1 | ALA4420072 | cell-based format | Patent Bioactivity Data | |
14. | ALA4420806 | B | Inhibition of TM4SF5 in human HuH7 cells assessed as reduction in cell number at 1 to 20 ug/ml incubated up to 3 days | Homo sapiens | 1 | ALA4420072 | cell-based format | Patent Bioactivity Data | |
15. | ALA4420812 | B | Inhibition of TM4SF5 in human SNU449Tp cells assessed as reduction in cell migration at 20 uM incubated for 18 hrs by Transwell chamber based assay | Homo sapiens | 1 | ALA4420072 | cell-based format | Patent Bioactivity Data | |
16. | ALA4420813 | B | Inhibition of TM4SF5 in human SNU449Tp cells assessed as reduction in cell invasion into collagen gel matrix at 20 uM incubated for 18 hrs | Homo sapiens | 1 | ALA4420072 | cell-based format | Patent Bioactivity Data | |
17. | ALA4420814 | B | Inhibition of TM4SF5 in human SNU449Tp cells assessed as reduction in cell invasion into Matrigel gel matrix at 20 uM incubated for 24 hrs | Homo sapiens | 1 | ALA4420072 | cell-based format | Patent Bioactivity Data | |
18. | ALA4420815 | B | Inhibition of TM4SF5 in human SNU449Tp cells assessed as reduction in MMP2 activity gel at 20 uM incubated for 24 hrs followed by medium exchange with serum-free medium and further incubated for 18 hrs by zymography | Homo sapiens | 1 | ALA4420072 | cell-based format | Patent Bioactivity Data | |
19. | ALA4420816 | B | Inhibition of TM4SF5 in human SNU449Tp cells assessed as reduction in MMP9 activity gel at 20 uM incubated for 24 hrs followed by medium exchange with serum-free medium and further incubated for 18 hrs by zymography | Homo sapiens | 1 | ALA4420072 | cell-based format | Patent Bioactivity Data | |
20. | ALA4420817 | B | Activation of TM4SF5 in human SNU449Tp cells in monolayer arrangement assessed as stimulation of cell growth at 20 uM incubated for 24 hrs by optical microscopy | Homo sapiens | 3 | ALA4420072 | cell-based format | Patent Bioactivity Data |